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Biomedical subjects

M Luce

Publications and source records attributed to M Luce.

21 records · Page 2Linked to original sources
PubMedDate not supplied

Rhinoreactivity in a patient affected by the Darier-White disease.

The Darier-White disease is a rare hyperkeratosic skin-disease which can also affect other organs. From an otoiatric point or view, there are alterations of the oral cavity, salivary glands and congenital deafness, but there is nothing against the nasal mucosa. The clinical case we studied, shows the presence of aspecific nasal hyperreactivity correlated to sun exposure as it happens for cutaneous lesions, independently of the presence of eosinophiles in the nasal secretion. This could mean that the Darler-White disease can also alter the function of the nasal mucosa.

Airway Obstruction↗
PubMedDate not supplied

The non-specific hypersensitivity of the upper and lower airways in Reinke's edema: preliminary results.

Reinke's edema is characterized by swelling of the vocal cords, which generally is bilateral but often is more pronounced in one cord. The disease is named after the anatomist Reinke, who undertook a morphological study of the subepithelial connective tissue of the vocal cords in order to investigate edematous spread. In general, swelling of the vocal cords develops gradually and may increase considerably over months or even years. To evaluate an eventual relation ship between airways (nasal and bronchial) and Reinke's edema of the vocal cords, the authors studied 9 subjects suffering from Reinke's edema. These patients underwent to an accurate clinical history, skin-test for inhalant pollens and mycetes to evaluate the eventual presence of specific allergies, non-specific nasal provocation test with Histamine, baseline RRM to evaluate the non-specific nasal hypersensitivity and besides the RRM values has been considered the number of sneezes after Histamine stimulation, finally a bronchial provocation test with ultrasonic fog to evaluate the presence of non-specific hypersensitivity of the lower airways.

Airway Obstruction↗
PubMedDate not supplied

Research of non-specific hyperreactivity of upper airways in subjects with gastro-esophageal reflux (G.E.R.): preliminary reports.

An association between asthma and gastro-esophageal reflux (GER) is well recognized but the underlying mechanism is still unclear. The authors suggest that could exist an association between GER and upper airways hyperreactivity and this association could represents the mechanism underlying the lower esophageal sphincter releasing, that determine the reflux. In fact they suppose that, the noxious injury of acid reflux follows a course that could be: pharynx-->larynx-->bronchi-->1/3 inferior of the esophagus-->reflux. From these presuppositions the authors carried out a study on the possible relationship between GER and non-specific hyperreactivity of upper airways on 14 subjects, divided in 2 groups: 10 subjects with functional GER, 4 subjects suffering from GER caused by hiatus hernia as control group. All patients had a thorough medical history, ENT examination with rigid and flexible endoscope, anterior Rhinomanometry (RRM), skin-test for inhalant and alimentary allergens, RAST, audiometric exam, non-specific nasal provocation test (NSNPT) with histamine, using as control the number of sneezes. From a through analysis of objective examination and from the results of the NSNPT with histamine resulted that all subjects with functional GER were rhinopathics. In all tests both in vivo (Skin-test) and in vitro(RAST) for the most common allergens (pollens-inhalant-mycophites-alimentary) the results were negative. The authors also found an involvement of paranasal sinuses that raised: 91% in the patients with recurrents phlogosis due to non specific nasal hyperreactivity; 40.9% in the allergic subjects (20% in the Graminacee +; 32% in the Parietaria O. +; 76% in the Dermatophagoides Pt. +; others 4%); 100% in the ASA-intolerance subjects. The NSNSPT with histamine showed in the group with functional GER a hyperreactivity with sneezes in 6/10 subjects, and 1/4 subjects of the group with GER with hiatus hernia. The RRM variations showed an unilateral nasal hyperreactivity in 6/10, bilateral in 3/10 subjects of the group with functional GER. In the group with GER with hiatus hernia only 1/4 subject showed reliable unilateral RRM variation. From the analysis of data resulted that subjects with functional GER showed a completely involvement of the upper airways and not only of the pharynx and larynx, caused by non specific hyperreactivity at the NSNPT with histamine, associated with a chronic pathology.

Adult↗