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M Luke

Publications and source records attributed to M Luke.

40 records · Page 3Linked to original sources

Long-term results of surgery for carcinoid tumours of the gastro-intestinal tract.

54 patients were followed-up 1-22 years (median 11 years) after histological verification of a carcinoid tumour. four patients died before operation; 41 patients had their lesion in the appendix, 13 in different extra appendiceal sites in the gastrointestinal tract. There was a significant difference between the median ages and the mortality rates in the two groups. Only one patient with an appendiceal tumour died of his disease. Appendiceal carcinoid, even with local spreading to the serosa and local lymph nodes, seemed to be adequately treated by a simple appendectomy. Extensive surgery, following the principles of treatment for malignant tumours, should be undertaken, when spread to the caecum or ascending colon is present or when the tumour is of extra-appendiceal origin.

Adolescent↗

Ceftriaxone/metronidazole is more effective than ampicillin/netilmicin/metronidazole in the treatment of bacterial peritonitis.

In a prospective, open, controlled clinical study, 190 consecutive patients who were thought to have bacterial peritonitis before operation, were randomised to antibiotic treatment during and after operation with either ceftriaxone 1 g plus metronidazole 1.5 g once daily (n = 94) or ampicillin 2 g plus netilmicin 150 mg twice daily plus metronidazole 1.5 g once daily (n = 96). Incisional and deep surgical wound infections, postoperative pneumonia and urinary tract infection as well as deaths caused by infection were recorded. Ceftriaxone-metronidazole was significantly more effective than ampicillin-netilmicin-metronidazole, 6/94 wound related infections (6%) compared to 18/96 (19%) (p = 0.02). In patients with peritonitis caused by a perforated colon or appendix the rates of clinical failure were 6% and 28%, respectively. We consider ceftriaxone plus metronidazole an efficient and easily administered antibiotic regimen in patients with bacterial peritonitis, and both the wide range of activity against Gram-negative aerobic rods and the long half life of ceftriaxone seem to be beneficial.

Adolescent↗