[Clinical trial of cimetidine in the treatment of vertigo].
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Biomedical subjects
Publications and source records attributed to M Lukomski.
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Fifty women with migrainous headaches were studied. The state of the vestibular system was assessed by ENG, including recording of spontaneous nystagmus, positional, thermal and kinetic nystagmus, recording of following of pendulum movements with eyes, and optokinetic nystagmus. ENG investigations were done in all cases between migrainous attacks, and in 20 cases also during migraine attack. During the attack in 18 women changes in the time of visual stimuli predominated, between the attacks ENG changes were observed in 24 cases.
The authors used a modification of ENG investigation which makes possible recording of the movements of each eyeball separately in two planes: horizontal and vertical. The authors used this method for analysis of cases with lesions of the motor nerves of to the eyeballs. The group included 20 patients with lesions of the motor nerves of the eyeballs of various origin. The control group included 20 healthy subjects. In nerve lesions a decrease of intensity of ENG tracings was observed when the rapid phase of nystagmus agreed with the direction of action of the eliminated motor nerves. Provocation of eyeballs to movements of lower amplitude but greater angular velocity (the test of induced nystagmus) increased changes. The change of deviation angle during investigation had also an effect on the appearance of pathological changes in the record. Changes were observed also in the motor activity of the unaffected eyeball.