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Biomedical subjects

M Lunder

Publications and source records attributed to M Lunder.

15 recordsLinked to original sources
PubMed2005

Peptide inhibitor of pancreatic lipase selected by phage display using different elution strategies.

Interference with fat hydrolysis results in the reduced use of ingested lipids. Inhibition of pancreatic lipase reduces the efficiency of fat absorption in the small intestine and thereby initiates modest long-term reduction in body weight. In an attempt to select peptides with affinity for the surface of pancreatic lipase and potential inhibitory activity, a random, cyclic heptapeptide phage-displayed library was used. Five independent selections, differing in elution step, were performed. In three selection protocols, a sequential elution strategy was applied in anticipation of improving the selection of high-affinity clones. Four heptapeptides with the highest affinity, seemingly for pancreatic lipase, were selected, synthesized, and characterized for their capacity to inhibit enzyme function. Although no clear consensus among the sequenced peptides was found, one of the selected peptides inhibited pancreatic lipase with an apparent inhibition constant of 16 muM.

Amino Acid Sequence↗
PubMed1992

Is Microsporum canis infection about to become a serious dermatological problem?

In Europe, especially in the Mediterranean, the incidence of Microsporum canis infection has been on a steep increase during the recent years. In some countries (Italy) and geographic areas (Slovenia), M. canis is the most often isolated dermatophyte. In Slovenia (Yugoslavia), a dramatic increase in the incidence of M. canis infection has been observed recently, both in absolute figures and as compared to the rest of isolated dermatophytes. M. canis is a cause of tinea most prevalent in children. All attempts made during the past 6 years to eliminate the natural source of infection, represented mainly by stray cats, have failed. M. canis infection is becoming a serious epidemiologic problem in Europe. For its solution, integrated efforts of medical and veterinary services, and probably more stringent rules and controls in this particular area, will be required.

Adolescent↗
PubMed1988

Variable incidence of nickel dermatitis.

The incidence of nickel sensitivity in Ljubljana, Yugoslavia, was stable in the periods 1972-1976 (6.7%) and 1977-1981 (6.3%). An increase became apparent when the incidence rose to 8.0% in 1982, and 9.1% in 1982-1986. The sex ratio in 1972-1976 was 2:1 with a female predominance, doubling to 4:1 in 1977-1981 and doubling again to 9:1 in 1982-1986. The highest incidence was in the age groups of 11-20 and 21-30 years. Nickel remains a rare cause of occupational dermatitis. Cheap metal jewelry is the likely source of the increased incidence.

Adolescent↗
PubMed1977

Thermodynamics of the isothermal interaction of beta-lactoglobulin with guanidinium chloride and urea.

A thermodynamic study of the isothermal interaction of beta-lactoglobulin with guanidinium chloride and urea has been performed. Enthalpies of interaction of the two denaturants have been obtained by calorimetric measurements, and the free energy of interaction calculated from previously determined preferential binding of denaturants. In separate dilatometric experiments the volume changes accompanying the interaction of guanidinium chloride with beta-lactoglobulin have also been determined.

Binding Sites↗
PubMedDate not supplied

Lack of efficacy of 6-week treatment with oral terbinafine for tinea capitis due to Microsporum canis in children.

Twenty-two children aged 2 to 9 years with noninflammatory tinea capitis due to Microsporum canis were evaluated in an open clinical pilot study run from January 1994 to July 1995. Each child was given oral terbinafine according to body weight for 6 weeks. Mycologic evaluation was done at the end of treatment and after follow-up periods of 4 and 8 weeks. None of the patients achieved complete mycologic cure by the end of the treatment period. Four weeks later complete mycologic cure was established in nine patients, and on final evaluation in seven. The treatment was very well tolerated by all the children. No systemic adverse effects were noted. According to our data, a 6-week course of oral terbinafine is inadequate for tinea capitis due to M. canis in children. Further study is needed to determine the most appropriate duration of therapy.

Administration, Oral↗