Biomedical subjects
Publications and source records attributed to M M Adams.
Minimal medium supplemented with sub-optimal levels of parental auxotrophic requirements increases recombinant recovery from matings of Nocardia erythropolis more than 500-fold when compared with nutrient agar matings.
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CONTEXT: Information about risk of recurrent preterm delivery is useful to clinicians, researchers, and policy makers for counseling, generating etiologic leads, and measuring the related public health burden. OBJECTIVES: To identify the rate of recurrence of preterm delivery in second pregnancies, factors associated with recurrence, and the percentage of preterm deliveries in women with a history of preterm delivery. DESIGN AND SETTING: Population-based cohort study of data from birth and fetal death certificates from the state of Georgia between 1980 and 1995. SUBJECTS: A total of 122 722 white and 56174 black women with first and second singleton deliveries at 20 to 44 weeks' gestation. MAIN OUTCOME MEASURE: Length of gestation (categorized as 20-31, 32-36, or > or =37 weeks) at second delivery compared with length of gestation at first delivery, by age and race. RESULTS: Most women whose first delivery was preterm subsequently had term deliveries. Of 1023 white women whose first delivery occurred at 20 to 31 weeks, 8.2% (95% confidence interval [CI], 6.6%-10.1%) delivered their second birth at 20 to 31 weeks and 20.1% (95% CI, 17.7%-22.8%) at 32 to 36 weeks. Of 1084 comparable black women, 13.4% (95 % CI, 11.4%-15.6%) delivered at 20 to 31 weeks and 23.4% (95% CI, 20.9%-26.1%) delivered at 32 to 36 weeks. Among women whose first delivery occurred at 32 to 36 weeks, all corresponding rates were lower than those whose first birth was at 20 to 31 weeks; the rates of second birth at 20 to 31 weeks were substantially lower (for white women, 1.9% [95% CI, 1.7%-2.2%]; for black women, 3.8% [95% CI, 3.4%-4.2%]). Compared with women aged 20 to 49 years at their second delivery, women younger than 18 years had twice the risk of recurrence of delivery at 20 to 31 weeks. Of all second deliveries at 20 to 31 weeks, 29.4% for white women and 37.8% for black women were preceded by a preterm delivery. CONCLUSIONS: Our data suggest that recurrence of preterm delivery contributes a notable portion of all preterm deliveries, especially at the shortest gestations.
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Previous immunohistochemical studies combined with retrograde tracing in macaque monkeys have demonstrated that corticocortical projections can be differentiated by their content of neurofilament protein. The present study analyzed the distribution of nonphosphorylated neurofilament protein in callosally projecting neurons located at the V1/V2 border. All of the retrogradely labeled neurons were located in layer III at the V1/V2 border and at an immediately adjacent zone of area V2. A quantitative analysis showed that the vast majority (almost 95%) of these interhemispheric projection neurons contain neurofilament protein immunoreactivity. This observation differs from data obtained in other sets of callosal connections, including homotypical interhemispheric projections in the prefrontal, temporal, and parietal association cortices, that were found to contain uniformly low proportions of neurofilament protein-immunoreactive neurons. Comparably, highly variable proportions of neurofilament protein-containing neurons have been reported in intrahemispheric corticocortical pathways, including feedforward and feedback visual connections. These results indicate that neurofilament protein is a prominent neurochemical feature that identifies a particular population of interhemispheric projection neurons at the V1/V2 border and suggest that this biochemical attribute may be critical for the function of this subset of callosal neurons.
CONTEXT: States need data on live births resulting from unintended pregnancies in order to assess the need for family planning services; however, many states do not collect such data. Some states may use extrapolated rates from other states. METHODS: Pregnancy Risk Assessment Monitoring System (PRAMS) data were assessed to explore the feasibility of extrapolating data on the percentage of live births resulting from unintended pregnancies from states that collect these data to states that do not. Data on women who had live births between 1993 and 1995 were examined for eight states: Alabama, Florida, Georgia, Michigan, New York (excluding New York City), Oklahoma, South Carolina and West Virginia. Logistic regression was used to determine state variation in the odds of delivering a live birth resulting from an unintended pregnancy after adjustment for maternal race, marital status, age, education, previous live birth and participation in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC). RESULTS: The percentage of live births resulting from unintended pregnancy ranged from 33% in New York to 49% in Alabama, Georgia and South Carolina. Compared with women in Alabama, women in Oklahoma were more likely to deliver a live birth resulting from an unintended pregnancy (odds ratio of 1.2, confidence interval of 1.1-1.3) and women in New York State were less likely (odds ratio of 0.7, confidence interval of 0.6-0.8) to have such a birth. However, unmarried white women in New York had lower odds of having a live birth resulting from an unintended pregnancy and married black women in Michigan had higher odds of having a live birth resulting from unintended pregnancy than their counterparts in Alabama. Although the percentages varied, in all eight states women who were black, were unmarried, were younger than 20 years of age, had less than 12 years of education or had more than one child had higher percentages of live births resulting from unintended pregnancy than women with other demographic characteristics. CONCLUSIONS: Data on which women have the greatest risk of delivering a live birth resulting from an unintended pregnancy may be extrapolated from one state to another, but the rate of such births may overestimate or underestimate the problem from one state to another.
Most infants with birthweights greater than or equal to 2,500 g who survive the first 27 days of life have a reasonable opportunity to grow into healthy children. However, some of these infants succumb to two potentially preventable causes of death: infections and injuries. Although the relationship between maternal attributes and risk of death from these causes has been described, little is known about how maternal attributes relate to postneonatal age at death. To examine this relationship, we analyzed postneonatal deaths from infections and injuries among 3,116,391 white and 638,915 black neonatal survivors with birthweights greater than or equal to 2,500 g. We grouped postneonates by maternal race and risk status. Infants of mothers greater than or equal to 20 years of age who started prenatal care in the first trimester were considered low risk; all others were high risk. For each category of infection death (respiratory, central nervous system, and other bacterial--including sepsis), neither race nor maternal risk status was related to age at death. The same was true for three categories of injury death (motor vehicle, fire, and homicide), but not for injury deaths in the category of choking, drowning, or suffocation. Among blacks, these deaths occurred at younger ages, regardless of maternal risk status. Thus, efforts to prevent deaths from choking, drowning, or suffocation among blacks should focus on early infancy.
In 1982-83, 4,485 persons ages 65 or older were identified by a household census in East Boston, MA: 3,812 (85 percent) of them responded to a health and social status questionnaire. Data on age, sex, and living arrangements for the 4,485 eligible people were analyzed with respect to final participation status and reason for refusal or reluctance. The health and social status of reluctant and ready self-respondents were compared, and respondents-by-proxy were compared with self-respondents. Total participation rates were similar for both sexes and all ages, but the likelihood of interview by proxy increased with age, as did the likelihood of nonparticipation due to unavailability. Living alone or with other participants favored participation, and living with refusers or other nonrespondents increased the probability of refusal. While reluctant and ready self-respondents differed in only one health variable and two social variables, respondents-by-proxy differed from self-respondents in most variables tested. These analyses suggest an absence of major differences between self-respondents and refusers. Therefore, nonresponse bias is not likely to have a major impact on interpretation of the data obtained from participants in this study.
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Projections from the US Bureau of the Census show that as the large "baby boom" cohort ages in the 1980s, the percentage of births to women 35 years or older will increase by 37%, while the percentage of births to teenaged women, the small post-baby-boom cohort, will decrease by 32%. Between 1980 and 1990, for women aged 35 to 44 years, fertility rates are projected to increase modestly, whereas for teenagers aged 15 to 19 years, fertility rates are projected to decrease modestly. Assuming that half of pregnant women aged 35 years or older request prenatal chromosomal diagnosis, an estimated 1.1 million pregnant women aged 35 years or older will request this service during the 1980s, increasing substantially the demand for it. Simultaneously, demand for prenatal care for teenagers will decrease, due to the decrease in births to teenagers.
OBJECTIVE: To determine whether women who received prenatal care in the third trimester differed from those who received no prenatal care. METHODS: We analyzed US birth certificates from 1990 through 1992, computing the distribution of live births for women who received prenatal care in the third trimester and for those who received no prenatal care according to eight demographic and pregnancy-related characteristics (age, race, marital status, residence, country of birth, education, interbirth interval, and parity). We used the Cochran-Mantel-Haenszel statistic to test the significance of the differences between the distributions for each characteristic, adjusting simultaneously for the other seven characteristics. RESULTS: Women who received no prenatal care differed from women who received prenatal care in the third trimester for each of the demographic and pregnancy-related characteristics we examined. Among black and unmarried women, the two categories of prenatal care differed by more than 10%. CONCLUSIONS: The characteristics of women who received no prenatal care and those of women who received prenatal care in the third trimester were heterogeneous. Strategies to promote earlier prenatal care should be specific and sensitive to women at risk for each category of late entry to prenatal care.
A woman's excessive drinking during pregnancy can cause structural and behavioral abnormalities in her offspring. However, population-based data concerning maternal drinking behaviors are sparse. To describe drinking prevalences and patterns, we analyzed self-reported data from the Pregnancy Risk Assessment Monitoring Systems of Maine, Michigan, Oklahoma, and West Virginia. During 1988 and 1989, 6,319 mothers were surveyed two to six months after delivery; state-specific response rates ranged from 65.6% to 83.5%. We applied statistical weights to the sample from each state; thus, the results estimate state-specific prevalences. State-specific prevalences of drinking during the last three months of pregnancy were low: 6.8% to 15.1% of mothers reported light drinking (one to six drinks per week), 0.06% to 0.30% reported moderate drinking (seven to 13 drinks per week), and 0.03% to 0.13% reported heavy drinking (14 or more drinks per week). In contrast, prevalences of drinking during the three months before pregnancy were much higher: the range was 31.9% to 53.8% for light drinking, 1.6% to 3.0% for moderate drinking, and 0.6% to 1.3% for heavy drinking. State-specific prevalences of mothers who reported receiving prenatal counseling about alcohol's effects ranged from 66.3% to 75.0%. More heavy drinkers than light drinkers received counseling. These findings indicate that moderate and heavy drinking during late pregnancy is relatively rare. However, all levels of drinking near the time of conception are much higher, and these results suggest the need for research into methods of reducing drinking before pregnancy.
Lower socioeconomic status (SES) is consistently associated with adverse pregnancy outcomes. One mechanism that may account for this association is that maternal health behaviors vary with SES. To examine this possibility, we addressed how women may be differently categorized by diverse measures of SES and the effect that choice of measure has on the relationship between SES and maternal health behaviors. We used population-based data for Caucasian women (n = 10,055) from Alaska, Maine, Oklahoma, and West Virginia who delivered a live infant in 1990-1991 and participated in the Pregnancy Risk Assessment Monitoring System. Five SES measures were evaluated: education; poverty status; Medicaid payment for delivery; Women, Infants, and Children (WIC) enrollment during pregnancy; and residential crowding. Three maternal health behaviors (smoking, delayed/no prenatal care, unintended pregnancy) were examined to assess the variation among the associations between SES measures and behaviors. Item response rates were high for all SES measures (range: 88.9%-100.0%), and there was low correlation between measures. Most of the SES measures were related to maternal health behaviors. However, the strength of association varied between each measure and behavior and was weaker for women who were younger than 20 years old or not married. In view of the multifaceted nature of SES, several measures may be needed to appropriately assess the relationship between SES and maternal health behaviors.
OBJECTIVE: To evaluate the prevalence of nonprone (supine or side) versus prone sleeping position in healthy preterm infants. STUDY DESIGN: A questionnaire on sleeping position was mailed to mothers of 167 preterm infants discharged from the intermediate nursery at Packard Children's Hospital at Stanford. The prevalence of nonprone sleeping at 1 month (term corrected age) and 3 months (2 months corrected age) after nursery discharge was analyzed by an unpaired t test. RESULTS: Nonprone position sleeping occurred in 64% initially and dropped to 35% at 2 months corrected age. CONCLUSIONS: Overall, nonprone sleeping was widespread in our healthy preterm infants after hospital discharge but may not persist. A majority of these infants were sleeping prone during a high-risk period for sudden infant death syndrome.