PubMed Health⌕ Search

Biomedical subjects

M M Averbakh

Publications and source records attributed to M M Averbakh.

At least 19 recordsLinked to original sources
PubMed1992

[Development of laboratory investigation methods in phthisio-pulmonology (summary of activities of the Central Research Institute of Tuberculosis, USSR Ministry of Health, during the twelfth 5-year plan of the laboratory section of the All-Union program 0.69.08)].

Comprehensive laboratory studies were performed to develop and introduce new techniques for examining patients with respiratory tuberculosis and some other pulmonary diseases. The techniques should improve and develop the immunologic and bacteriological diagnosis of tuberculosis, sarcoidosis, various exogenous allergic alveolitis and nonspecific inflammatory (microbial and mycotic) pulmonary diseases. Some of the methods were elaborated for morphological verification of sarcoidosis, alveolitis and rare pulmonary diseases. Radioimmuno-, enzyme immuno-, and other assays for the activity of various enzymes, as well as biochemical methods for assessing the superficial properties of individual cellular elements have found application in performing biochemical studies in pulmonary tuberculosis and non-specific diseases. Immunologic, bacteriological, cytologic and biochemical methods of study have been adjusted to examine the amount of bronchoalveolar washings in patients with different pulmonary diseases.

Alveolitis, Extrinsic Allergic↗
PubMed1991

[The course of experimental staphylococcal sepsis in opposite mouse strains and first-generation hybrids].

The survival time and histological lesions of the kidneys, liver, heart, and lungs were studied in CBA/Sto, C3HA/Mv and F1 (C3HA/Mv x CBA/Sto) mice for 15 days after i.v. injections with S. aureus pathogenic strains CFU B-243 in doses of 10(9), 10(8) and 2.5 x 10(8) microbial cells. CBA/Sto mice were found relatively resistant and C3HA/Mv mice, susceptible to infection caused by different doses of S. aureus, this being associated with different morphological picture in the viscera. F1 hybrids were at least as susceptible to the infections as any of the parent strains, suggesting recessive inheritance of resistance to staphylococcal infection.

Animals↗
PubMed1991

[A new method of the evaluation of lymphocytes and monocytes during immune response in patients with tuberculosis and sarcoidosis].

Examination which included 21 patients with tuberculosis, 6 with sarcoidosis and 9 healthy volunteers was aimed at determining the amount and intensity of surface fluorescence of CD+3, CD+4, CD+8 lymphocytes and CD14+, KIM+I monocytes. The findings demonstrate that determination of the fluorescence intensity of lymphocytes and monocytes provides a more exact characterization of the morphofunctional state of cells involved in the immune response. It is shown in particular that tuberculosis and sarcoidosis patients exhibit a varying density of the expressed antigenic markers of lymphocytes, which increases only in sarcoidosis, except a suppressor subpopulation (cytotoxic lymphocytes). Patients with tuberculosis had decreased density of CD9+, CD14+ and KIMI markers on the particular subpopulations.

Adult↗
PubMed1989

[The blood count of regulatory T-lymphocyte subpopulations in patients with pulmonary tuberculosis].

Important aspects are discussed of clinical evaluation of regulatory subpopulations of T-lymphocytes (T-helpers and T-suppressors) in the blood of patients with pulmonary tuberculosis. Imbalance of these subpopulations in the patients with normal values of E-REG BTR with PHA allows to establish immunity disorders in supplementary group of patients. Subpopulation imbalance is an unfavourable prognostic sign and one of indications to immunomodulating therapy.

Female↗
PubMed1988

[Regulation of antitubercular immunity in mice by genes of the H-2 complex].

Development of DTH reaction and survival time after M. tuberculosis H37Rv infection have been studied in H-2 congenic and recombinant mice pretreated with high doses of BCG vaccine. In addition, in vitro proliferation of lymphocytes from infected CBA, B6 and 4R mice to PPD was studied in the presence of anti-I-A and anti-I-E mAbs. High doses of BCG vaccination (1 mg/mouse) have led to a significant inhibition of DTH and diminution of survival time in B10.M (H-2f) mice only, and to opposite effects in all other strains tested (H-2a, b, d, k, h4). In I-A+, I-E- 4R mice anti-I-Ak mAbs abrogated lymphocyte proliferation to PPD completely, while in I-A+, I-E- CBA mice only the mixture of anti-I-Ak and anti-I-Ek mAbs was effective.

Animals↗
PubMed1986

[Genetic aspects of experimental tuberculosis in mice].

Susceptibility of inbred mouse strains, their F1 hybrids, offsprings from BC1 and RI strains from CXB pannel to tuberculosis infection was studied. Mice were infected with virulent strain of M. tuberculosis H37Rv. All F1 hybrids, with the exception of (BRSUNT X I/St)F1, showed superresistance, due apparently to heterosis effect; (BRSUNT X I/St)F1 demonstrated an intermediate level of resistance, as compared with parental strains. Analysis of [(BALB/c X B6)F1 X B6]BC1, [(BALB/c X B6)F1 X BALB/c]BC1 offsprings and RI strains indicated that strains BALB/c and B6 have different alleles of at least two genetic loci mediating susceptibility to tuberculosis.

Alleles↗
PubMed1986

[Caroli's disease].

Explore the source record for details and available documents.

Bile Ducts, Intrahepatic↗
PubMed1983

[Effect of a specific alloantiserum against T-suppressor cells on the resistance of mice to tuberculosis].

Mouse alloantiserum obtained by immunization of/DBA/2X XB10. A (3R)/F1 hybrids with thymic lymphocytes stimulated with Con A of B10.A(%) mice (anti-I-Jk) was tested in the microcytotoxic assay and in functional test of the survival of mice infected with tuberculosis. Serum was found to react with population of the cells from the lymph nodes of A/Sh, A2G, B10.AKM, and A.TL (I-Jk) mice, and was not active with B10.HTT (I-Js), B10 (I-Jb), B10,D2 (R107) (I-Jb), B6-H-2bm3 (I-Jb). Administration of the antiserum to mice infected with tuberculosis made the survival of the I-Jk-bearing strains significantly longer.

Animals↗