Biomedical subjects

M M Bidiuk

Publications and source records attributed to M M Bidiuk.

2 recordsLinked to original sources

PubMed2000

[A chronic hyperimmunocomplex process and its interrelationship with free radical-generating systems].

On chronic hyperimmunocomplex process (CHIP) model in rats of Wistar line (Cochrane C., Koffen D., 1973) we determined cAMP and cGMP concentration, nitrogen oxide (NO), urine, urine acid,--in muscle and clearance organs, and also in plasma. In result of carried out investigations there was determined the increase of large and middle CIC in blood plasma, their fixation on endothelium of aorta bifurcation and glomerula basal membrane, partially on liver cells. There was revealed considerable disbalance of cyclic nucleotides concentration in kidneys homogenates, spleen and plasma, with guanils fall (adenil index, what is interconnected with NO level lowering in all cases and urine increase in plasma, simultaneously with its decrease in number--in kidneys and spleen. Urinic acid increased in number in kidneys, spleen, plasma. These changes create favourable background for damaging of endothelium-neutrophil-thrombocyte cooperation through hemokinin, moleculo-adhesive, fermentative mechanism with further development of proliferative-remodulating processes in vessel wall.

Animals↗

PubMed1997

[The participation of neutrophilic mechanisms in the pathogenesis of chronic elevated blood immune complexes].

For reproduction of chronic hyperimmunocomplexemia model the classic Cochrane C. G., 1973 elaboration was used. The circulating immune complexes (CIC) were identified by precipitation methods, and fixated--by immunofluorescent in endothelium reproduction of aorta, and their clearance organs--liver and spleen. The estimation of neutrophil status was carried out according to rosette-forming neutrophils ability--by latex, zimosane, mieloperoxidasa, NST tests. The growth of large and middle CIC in vessel bed was estimated, their fixation in aorta bifurcation, and also on liver and spleen calls, but their intensivity is less, comparing to aorta endothelium. The neutrophil status was characterised by O-neutrophils growth, strengthening of capturing macrophages function, considerable activation of fermentative polynuclear systems, although reserve possibilities in them grew in less degree. Morphologic investigations allow to speak mediatingly about neutrophils participation in endotheliocytes damage, and also about their ability to secure the mononuclear cells further participation in damaging of aorta walls and partially of liver and spleen.

Animals↗