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Biomedical subjects

M M Finn

Publications and source records attributed to M M Finn.

6 recordsLinked to original sources
PubMed1994

Follicular and luteal phase salivary progesterone profiles in women with endometriosis and infertility.

Twenty-three women with laparoscopically diagnosed early-stage endometriosis collected daily saliva samples at home and brought them to the laboratory at the completion of each menstrual cycle. Levels of progesterone in the saliva were determined by enzymeimmunoassay. Samples were collected for three cycles by one patient, for two cycles by 15 patients and for one cycle be seven women, resulting in a total of 40 cycles for analysis. Only 20 (50%) cycles were classified as normal. In 18 cycles (45%) progesterone levels exceeded the 95th percentile of the normal range. These high levels occurred in the follicular phase only in seven (18%) cycles, in the luteal phase only in eight (20%) and in both follicular and luteal phases in three (7.5%) cycles. Three cycles were anovulatory. One of these cycles also demonstrated elevated progesterone levels in the follicular phase and is therefore included in the 18 cycles mentioned above. We conclude that ovarian function is altered in a significant number of infertile women with endometriosis. However, these alterations are often subtle and only detected by detailed investigation.

Adult↗
PubMed1992

The frequency of salivary progesterone sampling and the diagnosis of luteal phase insufficiency.

A profile of salivary progesterone concentrations, based on daily samples taken over a full menstrual cycle, provides a detailed picture of changes in luteal function, at the expense of analyzing a large number of samples. Strain can be placed on analytical services by assaying daily samples instead of one or a few serum (or saliva) samples. This study sought to determine the minimum number of salivary progesterone determinations which adequately describe luteal function. Daily salivary progesterone levels from 215 cycles, of which 29 cycles had progesterone profiles indicative of luteal phase insufficiency, were analyzed to ascertain the efficiencies of various sampling patterns of reduced frequency. A single mid-luteal salivary progesterone estimation or the mid-luteal Lenton progesterone index (n = 4) satisfactorily reflected the normal luteal phase, but a frequency of one sample every 3 days over the luteal phase (n = 5-6) was necessary to allow recognition of a short luteal phase or poor progesterone surge.

Adult↗
PubMed1989

Follicular growth and corpus luteum function in women with unexplained infertility, monitored by ultrasonography and measurement of daily salivary progesterone.

Ovarian function was evaluated over a minimum of 3 consecutive menstrual cycles from each of 41 women with unexplained infertility. Follicular development and ovulation were monitored using real time ultrasonography and luteal function was evaluated by daily salivary progesterone measurement. In 129 spontaneous cycles, normal single ovulations were detected in 121 (93.8%). Luteal phase insufficiency was identified in 21 (17.4%) of these 121 cycles and this was a recurrent phenomenon in the cycles of 5 of the 41 women (12.2%). A successful pregnancy was seen only in association with consistently normal salivary progesterone profiles or where the empirical use of clomiphene citrate therapy had corrected previously diagnosed luteal phase insufficiency. Basal body temperature records or mid-luteal serum progesterone measurements were less satisfactory indices of luteal function than a salivary progesterone profile.

Adult↗
PubMed1988

Normal salivary progesterone levels throughout the ovarian cycle as determined by a direct enzyme immunoassay.

This study, which is concerned with establishing clinically relevant corridors defining normal progesterone (P) levels in saliva, has addressed some of the shortcomings associated with previous equivalent studies (e.g., limited data, inadequately monitored ovulations, inadequately defined subjects). A sensitive, direct, microtiter plate, enzymeimmunoassay (EIA) for progesterone developed in the authors' unit, was used to determine daily salivary progesterone concentrations over 41 menstrual cycles in 41 women. Each woman was without associated factors known to affect ovarian function and each cycle included was judged to be (single) ovulatory by serial pelvic ultrasound examinations. Daily salivary progesterone levels from these cycles were statistically analyzed and corridors of progesterone concentrations associated with normal luteal function were established.

Female↗