Impairment of blood-CSF barrier in patients with neurological complications following acute haemorrhagic conjunctivitis.
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Blood-Brain Barrier↗
Biomedical subjects
M M Gore
Publications and source records attributed to M M Gore.
Interferon induction by flavi- and orbiviruses in L-M cell line.
Interferon (IFN) inducing ability of six flaviviruses was compared with five orbiviruses in mouse fibroblast cells (L-M). Orbiviruses were found to induce significantly higher amounts of IFN than flaviviruses.
Animals↗
Acid labile type alpha interferon induction by formalinized Staphylococcus aureus (Cowan I) in human mononuclear leukocytes.
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Adult↗
Cerebrospinal fluid immunoglobulins in acute transverse myelitis.
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Acute Disease↗
Natural killer cell activity in oral cancer patients. I. Correlation with tumor size and metastasis in regional lymph nodes.
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Adult↗
Natural killer cell activity in oral cancer patients: II. Correlation of in-vitro modulation by leukocyte interferon with circulating interferon and interferon induction by K 562 cells.
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Adult↗
Interferon (type-alpha and gamma) production by fresh and cryopreserved human mononuclear cells. Brief report.
A comparative study of interferon (IFN) production (type-alpha and gamma) was carried out using Ficoll-hypaque purified fresh and cryopreserved mononuclear cells from eight normal healthy individuals. Newcastle disease virus-NDV (R2B strain) was used as an inducer for type-alpha and Staphylococcal enterotoxin-A-(SEA) for type-gamma IFN production. There was no significant difference between the titres of type-alpha and gamma-IFN and lymphocyte subpopulations of fresh and cryopreserved mononuclear cells studied under identical conditions.
Adult↗
Lymphocyte subpopulations in Guillain-Barre syndrome.
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Humans↗
Recognition of helper T cell epitopes in envelope (E) glycoprotein of Japanese encephalitis, west Nile and Dengue viruses.
Helper T (Th) cell antigenic sites were predicted from the primary amino acid sequence (approximately 500 in length) of the envelope (E) glycoprotein (gp) of Japanese encephalitis (JE), West Nile (WN) and Dengue (DEN) I-IV flaviviruses. Prediction of Th epitopes was done by analyzing the occurrence of amphipathic segments, Rothbard-Taylor tetra/pentamer motifs and presence of alpha helix-preferring amino acids. The simultaneous occurrence of all these parameters in segments of E gp were used as criteria for prediction as Th epitopes. Only one cross reactive epitope was predicted in the C-terminal region of the E gp predicted segments of all flaviviruses analyzed. This region is one of the longest amphipathic stretch (approximately from 420 to 455) and also has a fairly large amphipathic score. Based on the predicted findings three selected peptides were synthesized and analyzed for their ability to induce in vitro T cell proliferative response in different inbred strains of mice (Balb/c, C57BL6, C3H/HeJ). Synthetic peptide I and II prepared from C-terminal region gave a cross reactive response to JE, WN and Den-II in Balb/c and C3H/HeJ mice. Synthetic peptide III prepared from N-terminal region gave a proliferative response to DEN-II in Balb/c strain only, indicating differential antigen presentation.
Algorithms↗