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Biomedical subjects

M M HARTMAN

Publications and source records attributed to M M HARTMAN.

14 recordsLinked to original sources
PubMed1963

Thrombo-embolic phenomena in severe asthma. Use of heparin for prevention and treatment in patients receiving ACTH or gluco-steroids.

Coagulation times and protamine titration values for heparin are apt to be lower than average in patients with allergic disease, particularly asthma. Severe asthma is commonly treated with gluco-corticoids or ACTH. Prolonged high dosage of gluco-corticoids, either endogenous or exogenous, depresses mast cell function and heparin production. Thrombo-embolic phenomena occur frequently in severe cases of asthma so treated, particularly if predisposing vascular disease is present. Heparin can be used to treat and prevent these complications. Adjuvant antiasthmatic effects under these conditions are noted in addition to the desired anticoagulation.

Adjuvants, Immunologic↗
PubMed1962

Dimethpyrindene. Use in high dosage hyposensitization therapy; prevention of constitutional and excessive local reactions.

To give larger doses of antigen for hyposensitization, yet hold down constitutional reactions and excessive local reactions, the antigen was mixed with epinephrine, ephedrine and dimethpyrindene, the latter a new antihistamine, just before subcutaneous injection. Dimethpyrindene, a potent antihistamine with minimal side effects, was also administered orally. The incidence of constitutional reactions and excessive local reactions was considerably diminished. Larger doses of antigens were tolerated and longer intervals between treatments were possible, a point of particular significance in maintenance therapy. There was less pain and discomfort at the site of injection and clinical results were improved.

Anti-Allergic Agents↗