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Biomedical subjects

M M Hreshchyshyn

Publications and source records attributed to M M Hreshchyshyn.

At least 37 records · Page 2Linked to original sources
PubMed1982

Vulvar intraepithelial neoplasia.

The authors reviewed the records of 50 patients with carcinoma in situ of the vulva seen at the State University of New York at Buffalo affiliated hospitals. Five patients (10%) were found to be immunosuppressed and 12 (24%) had other preinvasive and invasive genital or extragenital neoplasia. Of 43 patients whose symptomatology was available, almost half (46.5%) were asymptomatic. The most common symptom was vulvar itching in 18 (42%), and 32 (65%) patients had white vulvar lesions. Thirteen patients underwent vulvectomy, 23 underwent wide local excision, 8 underwent skinning and skin graft, 3 underwent topical 5-fluorouracil treatment, and 2 underwent CO2 laser treatment. On follow-up there were 6 patients with recurrent and/or persistent disease. Two recurrences followed wide local excision. Topical 5-fluorouracil failed in all 3 patients and CO2 laser failed in 1 of the 2 underwent laser treatment. There were 5 patients with invasive disease. In 3, diagnostic biopsy failed to reveal invasive neoplasia before surgical excision, and invasion was noted after 5-fluorouracil application in one and after CO2 laser treatment in another. All recurrences responded to therapy. In 41 patients followed up for 3 months to 11 years, there were no cancer-related deaths.

Adolescent↗
PubMed1982

Colposcopic patterns and their histopathologic correlation.

White epithelium, mosaicism, punctation, and atypical vessels are internationally used colposcopic terms describing an atypical transformation zone. Other morphologic findings are surface contour, clarity of demarcation, and tone of whiteness with or without atypical vessels. In the State University of New York at Buffalo affiliated hospitals, 665 cervical and vaginal atypical colposcopic patterns of 552 patients were matched with their histologic findings. Mosaicism, punctation, and white epithelium correlated with the histologic diagnosis of vaginal intraepithelial neoplasia and cervical intraepithelial neoplasia in 43%, 55%, and 42% of the cases, respectively. When white epithelium accompanied the mosaicism or punctation, the incidence of histologically confirmed vaginal and cervical intraepithelial neoplasia raised to 66% and 68%, respectively. In patients with prenatal DES exposure, mosaicism rarely (17%) correlated with the histologic findings of vaginal and cervical intraepithelial neoplasia. Overall, there was a great variability in the correlation depending on the specific colposcopic abnormalities.

Cervix Uteri↗
PubMed1981

Topical 5-fluorouracil treatment of vaginal intraepithelial neoplasia.

In a prospective study, 27 patients with intraepithelial vaginal neoplasia diagnosed by colposcopically directed biopsies were treated with topical 5-fluorouracil. The cream was applied daily to the entire vagina until mucosal irritation occurred (5 to 10 days). Courses were repeated every 2 weeks for a total of 2 to 3 courses, which were considered 1 treatment, before response was evaluated. Those found to have persistent neoplasia as designated by positive vaginal cytology and/or colposcopically directed biopsies received a second 3-course treatment and were evaluated again. Except for 2 patients (1 who died from intercurrent disease during the treatment and another, evaluated prematurely after the first course of therapy, who was found to have persistent disease and was treated by other means), all patients responded with complete regression of vaginal intraepithelial neoplasia. Three patients developed reactivation of disease within 1 year, were retreated, and are currently completely free of disease. The authors believe the results of this study are very encouraging.

Administration, Topical↗
PubMed1980

The role of adjuvant therapy in Stage I ovarian cancer.

Women with Stage I epithelial carcinoma of the ovary were initially treated by an extirpative operation and were subsequently randomized to either no further treatment, radiotherapy, or chemotherapy. Only two patients (6%) treated with chemotherapy developed recurrence, compared to five (17%) and seven (30%) patients in the no-treatment and radiotherapy regimens, respectively (P < 0.05). All patients, with the possible exception of those with Stage IA(1)g1, appeared to benefit from adjuvant chemotherapy compared to no treatment or radiotherapy.

Adenocarcinoma↗
PubMed1980

Specific cytogenetic changes in ovarian cancer involving chromosomes 6 and 14.

Cytogenetic studies were performed in 12 papillary serous adenocarcinomas of the ovary. Of the more than 19 clonal structural chromosome abnormalities observed in these cancers, 6q- and 14q+ were found to be the most frequent. Both markers coexisted in the cells of eight cases; in the other four cases, either a 6q- or 14q+ was present. In at least six cases, the additional segment on the long arm of chromosome 14 appeared to originate, on the basis of the chromosomal quantity and fluorescence pattern, from the missing part of chromosome 6. This suggested that the 6q- and 14q+ markers had arisen as a result of a reciprocal translocation at Bands q21 and q24, respectively, i.e., t(6;14)(q21;q24). However, it is uncertain in the remaining six cases whether an identical type of translocation was responsible for the formation of the markers. Thus, abnormalities involving chromosomes 6 and 14 seem to be specifically associated with papillary serous adenocarcinoma of the ovary.

Adenocarcinoma, Papillary↗
PubMed1978

Treatment of malignant ovarian germ cell tumors: response to vincristine, dactinomycin, and cyclophosphamide (preliminary report).

From November 1971 to November 1975, 27 patients with malignant germ cell tumors of the ovary (excluding pure dysgerminoma and tumors containing trophoblastic elements) were treated with vincristine, dactinomycin, and cyclophosphamide; 12 patients received other therapy. Fourteen tumors were pure endodermal sinus tumors, two were embryonal carcinomas, 11 were mixed germ cell tumors and 12 were immature teratomas. Of 23 patients with surgically resected disease (Stages I-IIA) only seven have failed. Median follow-up for 16 patients remaining free of disease is 24.5 months. Restaging (second-look) laparotomies were done in 15 patients. Eight were negative. Fifteen of the patients had tumors with endodermal sinus elements. Six of these have failed. Of 16 patients with advanced disease (Stage IIB, III and recurrent), eight have responded to chemotherapy, eight have failed. Median follow-up period for those remaining free of disease is 26.5 months. Six have had negative second-look surgery and one had mature teratoma. Four of eight cases which contained endodermal sinus elements responded to chemotherapy and remain disease-free. Grade 3 hematologic toxicity was seen in eight patients, dose-limiting gastrointestinal toxicity in five patients, dose-limiting neurotoxicity in five patients.

Adolescent↗
PubMed1975

Urinary gonadotropins in management and prognosis of testicular tumor.

Ninety-three cases of germinal testicular tumors with urinary gonadotropin (HCG) values, estimated by biologic or radioimmunoassay techniques, were reviewed. Preoperative values of HCG and subsequent postoperative values were related to response to treatment and prognosis. Twenty-five patients (26.9 per cent) comprised the seminoma group, and 68 patients (73.1 per cent) the nonseminomatous groups of germinal neoplasms. High HCG values were observed in the nonseminomatous group pre- and postoperatively by both assay procedures. Most significant was the high HCG values postoperatively (p smaller than 0.05, x2 equals 5.21 and p smaller than 0.05, x2 equals 5.23) for the biologic assay and radioimmunoassay, respectively, with high HCG values being associated with a poor cumulative 24 per cent two-year survival rate. Urinary HCG assay is of prognostic value in the ongoing management of testicular neoplasms. In the future, serum HCG assays may be of additional benefit.

Adolescent↗
PubMed1975

Results of the Gynecologic Oncology Group trials on ovarian cancer: preliminary report.

Preliminary results of three prospective controlled ongoing Gynecologic Oncology Group studies in ovarian carcinoma are discussed. The first study involves "Postoperative Treatment of Women With Resectable Ovarian Cancer With Radiotherapy, Melphalan, or No Further Treatment" (77 evaluable patients). Although there is a trend favoring chemotherapy, the differences as yet are not statistically significant. The second protocol evaluates "Postoperative Treatment of Women With Stage III Ovarian Cancer by Radiotherapy or Melphalan, Either Alone or in Both Sequences" (141 evaluable patients). The progression-free interval is shorter with either therapeutic modality alone and longer with the two combinations of radiation and chemotherapy. The third protocol deals with "Treatment of Women With Disseminated or Recurrent Advanced Ovarian Cancer With Melphalan Alone, in Combination With 5-FU, in Combination with 5-FU and Dactinomycin, or in Combination with Cytoxan, 5-FU, and Dactinomycin" (200 evaluable patients). In terms of progression-free interval, the study favors combination chemotherapy.

Antineoplastic Agents↗