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M M Izatt

Publications and source records attributed to M M Izatt.

8 recordsLinked to original sources
PubMed1978

HLA antigens and IgG allotypes on the Island of Barra (Outer Hebrides).

The distribution of HLA antigens and IgG allotypes in a group of nearly 200 adults on the Island of Barra, shows some unusual features. The sample tested included only people age 65 and over. Marked differences in the frequency of some HLA antigens were noted, compared to those previously determined for the northern island of Lewis and Harris, with increase in the frequency of HLA-A5 and B7. The latter antigen was present in over 40% of the group, compared with a frequency of 27% in the Northern islands. The high frequencies of HLA-A2, the Aw19 group and B12 previously noted in Scottish populations were also present. The IgG allotype, Gm (f;b4) was markedly increased, being present in 67% of the group, in comparison with frequencies of 40--45% in previous Scottish studies. These results either suggest a sampling phenomenon, or may be an indicator of selective forces related to immunological mechanisms or the age distribution of the population studied.

Aged↗
PubMed1977

Bioassay of kinship in northwestern Europe.

Kinship of Barra (Outer Hebrides) is bioassayed as 0.0096 relative to northwestern Europe, in reasonable agreement with prediction of 0.008 relative to Britain. The exponential decline of kinship with distance is similar to Scandinavia. Kinship of larger populations is consistent with predictions from isolates. Kinship is largely due to local drift rather than Norse admixture, the estimate of which is obscured by drift and appears highly unreliable. Other populations in northwest Europe, including Iceland, Lewis and Orkney, give estimates of kinship which reflect drift and geography, but also do not provide reliable estimates of admixture. Bioassay of kinship from gene frequencies gives observations to be explained in terms of migration and drift, but contributes nothing to the question of whether polymorphism in the species is maintained by neutral mutation or selection. Although the latter is on various grounds more likely, no calculations based on gene frequency distribution can provide critical evidence.

Emigration and Immigration↗
PubMed1976

Blood groups antigens, plasma protein and red cell isoenzyme polymorphisms in south-west Scotland.

Blood donor specimens from South-west Scotland were analysed for the following polymorphisms: ABO, Rhesus (D), Haptoglobin, Transferrin, Immunoglobulin (GM), RBC acid phophatase, RBC phosphoglucomutase and RBC adenylate kinase. Genetic differences exist between the regions in S.W. Scotland and between S.W. Scotland and other Irish and Irish Sea regions. This variability is detailed and discussed. The results are mapped by converting the data into distance values and by using a nonmetrical scaling technique. Overall the present S.W. Scotland data are similar to Cumbrian and Manx results and dissimilar to the Irish data.

ABO Blood-Group System↗