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Biomedical subjects

M M Kamel

Publications and source records attributed to M M Kamel.

At least 19 recordsLinked to original sources
PubMed2004

Removal of azo and anthraquinone dyes from aqueous solutions by Eichhornia Crassipes.

The rate of adsorption of two azo and four anthraquinone anionic dyes on Eichhornia Crassipes (E.C.) has been studied. Raw E.C. and three aminated derivatives of E.C. with different nitrogen percent were used as dye adsorbents. The parameters studied include the amount of substrate, shaking time, chemical structure, concentration of dyestuff and pH of dyeing bath. Simple kinetic adsorption models of dynamics and adsorption parameters for the Langmuir and Freundlich isotherms were determined. A higher nitrogen percent of aminated E.C. showed a higher adsorption capacity than other derivatives. The kinetic adsorption models indicate that the decolourization was complete in a relatively short time (10 min) and the reaction taking place is of the first order. The equilibrium data fit well with the Freundlich model of adsorption for the six dyes. Only dye IV (C.I.A Acid Blue 25) conform both Freundlich and Langmuir adsorption isotherms.

Adsorption↗
PubMed2000

Effect of cyclophosphamide-mediated immunodeficiency on murine Schistosomiasis mansoni.

Four groups of female C57BL/6 mice were used. The first group was infected with 500 unattenuated cercariae. The second group was immunosuppressed by cyclophosphamide (Cy) before infection with the same dose of cercariae. The third group was exposed to 500 partially attenuated cercariae while the fourth group was immunosuppressed with (Cy) before exposure to 500 partially attenuated cercariae. In response to infection with either unattenuated or partially attenuated cercariae, the total worm burden was significantly reduced. In the meantime, the level of serum specific anti-SWAP IgG1 was significantly higher and a specific band at 32 kDa was recognized in the infected groups (first and third) compared to that in the immunosuppressed groups (second and fourth). Scanning electron microscopy observations revealed severe damage and deformities on the tegument of worms of the third group compared to less damage detected on the tegument of worms in the fourth group. No obvious changes could be detected on the tegument of worms developed from the second group compared to the first group (controls). These observations taken together indicate that the high level of anti-SWAP IgG1 may have a role in the elimination of schistosomes after primary infection of mice with either unattenuated or partially attenuated S. mansoni cercariae. Moreover, this immunoglobulin together with UV-induced attenuation produce severe damage on the tegument of worms developed from mice exposed to partially attenuated cercariae.

Animals↗
PubMed1988

Ultrastructural observations in Darier's disease.

Two patients with Darier's disease--diagnosed clinically by the presence of characteristic keratotic papules in seborrheic areas--were biopsied for light- and electron-microscopic studies. Light microscopy revealed typical histologic features of Darier's disease. Ultrastructural studies showed the presence of cytoplasmic processes projecting from the basal keratinocytes (basal keratinocyte herniations) into the underlying dermis through small defects in the basal lamina, which was intact in some areas but in other locations showed thickening, irregularity, and replication. Widening of the lamina lucida with partial or complete disappearance of hemidesmosomes were noted in many areas.

Acantholysis↗
PubMed1987

Effects of a lengthy period of undernutrition from birth and subsequent nutritional rehabilitation on the synapse: granule cell neuron ratio in the rat dentate gyrus.

Recent evidence showing alterations in spatial memory due to a period of undernutrition during early life has implicated the hippocampus as one of the brain centres that may be particularly adversely affected. However, there are very few quantitative morphological studies that have examined the neuronal and synaptic populations of the hippocampi from undernourished animals. We decided to carry out such experiments, paying particular attention to the granule cell of the dentate gyrus. Male rats were undernourished from the 18th day of gestation until 21, 75, or 150 days of age. Some of these previously undernourished rats were nutritionally rehabilitated between 150 and 250 days of age. Groups of well-fed control and experimental rats were killed by intracardiac perfusion with 2.5% sodium-cacodylate-buffered glutaraldehyde. The right hippocampus from each rat was dissected out and processed for electron microscopy. Stereological procedures at the light and electron microscopical levels were used to estimate the numerical densities of granular cell neurons and molecular layer synapses in the dorsal lip of the dentate gyrus. These estimates were used to calculate synapse: neuron ratios. There were 5,056 +/- 347 (mean +/- SE) and 5,002 +/- 190 synapses per neuron in 21-day-old control and undernourished rats, respectively. By 75 days these values had increased to 9,215 +/- 588 and 6,683 +/- 237. The difference was statistically significant. By 150 days of age the value for control animals had fallen once again to 6,518 +/- 209 whereas undernourished rats had increased slightly to 7,689 +/- 288 (P less than .01); 250-day-old rats, previously undernourished from birth to 150 days of age, showed a substantial increase in the synapse: neuron ratio during the period of nutritional rehabilitation. Thus these nutritionally rehabilitated rats had 9,407 +/- 365 synapses per neuron whereas age-matched controls had only 6,323 +/- 239 (P less than .01). These results indicate that the rat dentate gyrus is vulnerable to undernutrition even during the postweaning period and that a lengthy period of undernutrition can alter the developmental growth curve for synapse: neuron ratios.

Animals↗
PubMed1987

Effect of praziquantel on certain immune responses of schistosomal Egyptian patients. I. Changes of specific immunoglobulins.

Specific antischistosomal IgG, IgM, and IgE were estimated by ELISA in 117 rural school students before specific treatment with praziquantel monthly for 3-4 months thereafter. IgG and IgM were estimated as percentage of bound antibodies. IgE was estimated by avidin-biotin ELISA (AB-ELISA) as IU/ml using a panel of known IgE standards. Soluble surface Schistosoma mansoni adult worm antigen was used for all estimates. Total IgE was estimated in a smaller group by an ELISA kit. The percentage of specific IgE was calculated. A group of endemic controls (22 students) and non-endemic controls (17 cases) were included. Statistical analysis of results showed the specific immunoglobulins to be significantly reduced 2 months after treatment of the schistosomal cases. These reduced levels, however, were still significantly higher than those of controls. The presence of early hepatosplenomegaly and the co-existence of other parasites had no significant influence on the results. No correlation could be established between the levels of specific antischistosomal IgG, M and E and the intensity of infection. The significance of these results is discussed.

Adolescent↗
PubMed1978

A comparison of buprenorphine and pethidine for immediate postoperative pain relief by the i.v. route.

A comparison was made of the relief of pain after operation, obtained following the i.v. administration of buprenophrine and pethidine in 60 patients with lower abdominal incisions. No difference could be detected between the maximum analgesia produced by eigher drug, but analgesia following buprenorphine appeared to last about four times as long as that following pethidine. When the drugs were compared on a "dose per body weight" basis the results supported a ratio of potency in the order of 1 : 200 in favour of buprenorphine. Vomiting, drowsiness and dizziness were less frequent following buprenorphine, but a similar frequency of nausea was observed with both agents. Marked miosis occurred 5--10 min after the i.v. injection of buprenorphine, but no serious side-effects were observed with either drug. The i.v. injection of buprenorphine, but no serious side-effects were observed with either drug. The i.v. administration of buprenorphine appeared to be effective in the management of pain after operation in patients with lower abdominal incisions.

Adult↗