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Biomedical subjects

M M Manning

Publications and source records attributed to M M Manning.

27 records · Page 2Linked to original sources
PubMed1983

Self-efficacy expectancies, outcome expectancies, and the persistence of pain control in childbirth.

Bandura's (1977) self-efficacy theory of mastery behavior distinguishes self-efficacy expectancies from outcome expectancies. The relative roles of self-efficacy expectancies, outcome expectancies, and importance were studied as predictors of persistence of pain control in medication-free childbirth. Fifty-two primiparous women made self-efficacy judgments before and during labor and then reported in postdelivery interviews the timing and amount of medication use during labor and delivery. Self-efficacy expectancies predicted persistence in pain control without medication better than outcome expectancies, importance, and seven other alternative predictors, supporting several aspects of construct validation of the self-efficacy expectancy construct. However, self-efficacy and outcome expectancies were very highly correlated and largely redundant in their correlations with mastery. Three possible reasons and implications for the lack of differentiation of self-efficacy and outcome expectancies are discussed.

Adult↗
PubMed1983

Characterization of a uterine-type oxytocin receptor in the rat hippocampus.

Extracellular recordings were obtained from a class of nonpyramidal neurones in hippocampal slices. Oxytocin applied to the bath at concentrations of 1 nM or greater excited these cells. This effect was reversibly antagonized by a synthetic structural analogue known to block the peripheral endocrine effects of oxytocin. The effect of oxytocin was mimicked by a selective oxytocic agonist and, with less potency, by vasopressin and by other structural analogues. The potencies of oxytocin, vasopressin, and of these analogues in the hippocampus correlated well with their uterotonic activities but not with their vasopressor or antidiuretic activities. The data suggest that a class of hippocampal neurones is endowed with receptors for oxytocin that are similar to those of uterine smooth muscle cells.

Action Potentials↗
PubMed1983

Treatment of small cell lung cancer with VP-16, vincristine, doxorubicin (Adriamycin), cyclophosphamide (EVAC), and high-dose chest radiotherapy.

Seventy-one previously untreated patients with small cell lung cancer (SCLC) received a combination of VP-16, vincristine, doxorubicin (Adriamycin), and cyclophosphamide (EVAC) repeated every three weeks. Limited-disease (LD) patients and extensive-disease (ED) patients achieving a complete response (CR) or partial response (PR) after four to six cycles of EVAC received 4,000 rads over four weeks whole-brain radiotherapy (RT) and 5,000 rads over five weeks RT to the original pulmonary primary and mediastinum. ED patients with persisting disease outside the chest after six cycles of EVAC continued chemotherapy and did not receive RT. After RT was completed, EVAC was continued for a total treatment duration of 24 months. Of 65 patients evaluable for response 76% (25 of 33) of LD patients and 34% (11 of 32) of ED patients achieved a CR prior to RT; two additional ED patients achieved a CR after RT. Median survival for all 71 patients was 48 weeks (range, one to 207 weeks); median survival for 33 LD patients was 92 weeks and for 38 ED patients it was 36 weeks. Nine of 25 LD patients and 10 of 13 ED patients have relapsed from CR. The EVAC-RT protocol is promising in view of the high CR rate and long remission duration achieved, especially among patients with LD.

Antineoplastic Combined Chemotherapy Protocols↗