Biomedical subjects

M M Marciniak

Publications and source records attributed to M M Marciniak.

3 recordsLinked to original sources

PubMed1997

Ophthalmomyiasis interna posterior and pigmentary retinopathy of Guam.

BACKGROUND: Ophthalmomyiasis is ocular invasion by a fly larva. In the United States, only two cases of bilateral subretinal ophthalmomyiasis have been reported in the literature. Subretinal invasion by the fly larva results in characteristic ophthalmoscopic and angiographic findings. Recently, similar subretinal changes have been associated with amyotrophic lateral sclerosis/Parkinsonism dementia complex (ALS-PDC) in the Chamorro population of Guam. This pigmentary retinopathy of Guam (PROG) is generally bilateral in presentation, whereas ophthalmomyiasis is generally unilateral. While PROG has been associated with neurologic findings, ophthalmomyiasis interna posterior (OIP) has not. CASE REPORT: A case of a 65-year-old Asian man with bilateral subretinal changes is described. Similarities and differences between ophthalmomyiasis and the pigmentary retinopathy of Guam are discussed. CONCLUSIONS: Because PROG has been associated with ALS-PDC, a neurologic evaluation should be included in the workup of patients suspected of having OIP or PROG.

Aged↗

PubMed1995

In vivo exposure to sodium fluoride does not modify the yield of viral tumour-induced periosteal bone nor of heterotopic bone induced by human tumour KB cells in mice.

In mice local or systemic administration of fluoride (5-25 mg NaF/kg body weight) during the proliferative phase of bone formation (up to 20 days) has no effect on the yield of bone formed either by local stimulation of periosteal membrane by Moloney sarcoma virus-induced tumour or on bone induced heterotopically by human KB cells. The lack of stimulatory activity of fluoride on rapidly induced osteogenesis in mice is in agreement with recent reports which show that fluoride is not a potent mitogen for human osteoblasts grown in vitro.

Animals↗

PubMed1994

Pediatric clinical decision making.

BACKGROUND: Clinicians systematically gather information and data, generate hypotheses, and using clinical judgment arrive at a diagnosis and treatment plan. This process may be difficult and time consuming. Analysis using decision-making algorithms provides the clinician with a model to simplify complex clinical situations. This decision-making strategy is particularly effective in the pediatric population because of the variability in the patient's responses. METHODS: This clinical strategy is presented for two clinical scenarios in pediatric patients, nystagmus and esotropia. Two clinical decision-making trees are presented with possible clinical approaches to problem solving. CONCLUSIONS: Decision analysis in the care of pediatric patients may be simplified by the development of decision-making algorithms. This explanation of the decision-making strategy will allow clinicians to develop a personal approach to problem solving in their clinical care.

Algorithms↗