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Biomedical subjects

M M Patterson

Publications and source records attributed to M M Patterson.

12 recordsLinked to original sources
PubMed1985

Sensory preconditioning in the rabbit following ACTH injections.

The effects of ACTH elevation on sensory preconditioning were examined using the rabbit NM response. Sensory preconditioning is an associative form of learning which is presumed to rely on a "stimulus map" provided by the hippocampus. Elevation of levels of ACTH was found to have no significant effect on SPC. This finding was interpreted as evidence that not all deficits found in hippocampal lesioned animals may be attributed to hormonal mediation. It was suggested that ACTH elevation may selectively mimic those deficits ascribed to a "neural model" process involving the hippocampus.

Adrenocorticotropic Hormone↗
PubMed1985

Fixation of spinal reflex alterations in spinal rats by sensory nerve stimulation.

Two preparations in which sensory nerve stimulation was used to obtain peripherally induced spinal fixation in spinal rats are described. In the first preparation, proportionally greater amounts of persisting poststimulation flexor muscle contraction, as measured by a force displacement transducer, were produced as stimulation time was increased from 10 min to 40 min. In the second preparation, sensory nerve stimulation was delivered, and evoked whole-nerve responses were recorded from a flexor motor nerve. Results indicated that 30 min or more of sensory nerve stimulation produced increases in response amplitude and area that persisted for at least 30 min after stimulation.

Animals↗
PubMed1979

Neuronal unit activity in the abducens nucleus during classical conditioning of the nictitating membrane response in the rabbit (Oryctolagus cuniculus).

Neuronal unit activity was recorded from the abducens (6th nerve) nucleus, the "final common path," during classical conditioning of the nictitating membrane (NM) response in the rabbit, with the use of a tone conditioned stimulus, an air puff unconditioned stimulus (UCS), 250-msec interstimulus interval, and 60-sec intertrial interval. Animals were given 2 days of conditioning training (104 trials in eight blocks per day) and 1 day of extinction. Control animals were given comparable periods of stimulus presentations, explicitly unpaired. Activity of small clusters of units--"multiple unit" recording--was compared with the amplitude-time course of the NM response. Between-blocks comparisons of neural and behavioral responses indicated an essentially perfect correlation during acquisition of the conditioned response (Day 1, r = .99; Day 2, r = .98) and a slightly lower correlation during extinction (r = .93) for the conditioning animals. Within-blocks comparisons indicated a close correspondence between the histograms of unit activity and the amplitude-time course of the NM response for the conditioning animals in all phase of training and for the control animals in the UCS trial blocks.

Abducens Nerve↗
PubMed1977

Classical nictitating membrane conditioning in the awake, normal, restrained cat.

Present knowledge of its central nervous system makes the cat a desirable subject for studies of brain-behavior relationships. Response frequencies and latency characteristics in conditioning and control groups indicate that the response of the nictitating membrane can be classically conditioned in a new restraint system in which detailed brain and behavior measures can be easily obtained.

Animals↗