PubMed Health⌕ Search

Biomedical subjects

M M Rahman

Publications and source records attributed to M M Rahman.

At least 127 records · Page 7Linked to original sources
PubMed1994

Structural studies of the O-polysaccharide from the lipopolysaccharide of Moraxella (Branhamella) catarrhalis serotype A (strain ATCC 25238).

The polysaccharide of the Moraxella (Branhamella) catarrhalis serotype A lipopolysaccharide was prepared by mild acid hydrolysis followed by gel permeation chromatography. The structure was established by methylation analysis, mass spectrometry, and NMR spectroscopy. It is concluded that the O-antigenic polysaccharide has the following structure. [formula see text] Methylation analysis of the intact lipopolysaccharide showed that the lipid A portion consisted of 6-substituted glucosamine residues. Methylation followed by methanolysis showed that two Kdo residues were present, one terminal and one 4,5-substituted residue. A terminal Kdo thus substitutes the branch-point Kdo in the 4-position.

Carbohydrate Conformation↗
PubMed1994

Impact of health education on the feeding of green leafy vegetables at home to children of the urban poor mothers of Bangladesh.

To evaluate the impact of health education on mothers, on the feeding of their children green leafy vegetables (GLV) at home, we studied 160 children aged 6 to 35 months and their mothers in two intervention groups and one comparison group. The mothers of the first intervention group (n = 44) were given health education including a feeding demonstration, by offering a single meal of cooked GLV to their children. The mothers in the second intervention group (n = 36) received health education only. Mothers of both the intervention groups were visited at home after eight weeks of intervention without prior notice, and for each of them an immediate neighbourhood mother having a child in the same age range was selected as a comparison mother (n = 80). During this visit, mothers were asked whether they had cooked GLV that day and fed these to their children; this was confirmed by spot-checking. Also, mothers were interviewed to elicit their perceptions about GLV. The percentages of mothers who thought that GLV are good for health were 88.7%, 86.1% and 76.2% in groups 1, 2 and comparison respectively (P = 0.06). However, the percentages of mothers who actually fed their children GLV were 57%, 64% and 26% in groups 1, 2 and comparison group respectively (P < 0.001). The influence of health education on GLV feeding persisted after controlling for the effect of maternal literacy (Mantel Haenszel chi-square = 16.99; P < 0.0001) and family income (Mantel Haenszel chi-square = 17.36; P < 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)

Bangladesh↗
PubMed1994

A new range of instruments ensuring easy and effective surgery for laparoscopic cholecystectomy.

To work with ease and comfort in laparoscopic cholecystectomy, four instruments (Tohoku dissector, Tohoku forceps, short mantis device, and long mantis device) have been developed that can be used by any surgeon, even one not accustomed to this new procedure. These instruments have the advantage of offering a feel of open surgery and have been in use since February 1991 with significant comfort and safety.

Arteries↗
PubMed1994

Changes in body composition of malnourished children after dietary supplementation as measured by bioelectrical impedance.

Body composition was measured with bioelectrical impedance in 35 malnourished children aged 24-59 mo to investigate the effect of a 3-wk feeding supplementation. Twenty children received a high-protein diet with 15% of total energy as protein, whereas 15 children received an isoenergetic standard-protein diet with 7.5% of energy as protein. Bioelectrical impedance analysis and anthropometry were done before and after 21 d of dietary supplementation. The children fed the high-protein diet gained significantly more body weight than those receiving the standard-protein diet (1.33 +/- 0.54 vs 0.88 +/- 0.47 kg, P < 0.02). The total body water and fat-free mass determined by bioelectrical impedance analysis showed that the group fed the high-protein diet increased significantly more (0.92 vs 0.58 kg) than those on the standard-protein diet (P < 0.02). Results of this study suggest that feeding a high-protein diet accelerates catch-up growth and restores the reference body composition in children recovering from malnutrition.

Body Composition↗
PubMed1994

Inhibitor regulation of tissue kallikrein activity in the synovial fluid of patients with rheumatoid arthritis.

Tissue kallikrein (TK) and alpha 1-antitrypsin (AT)/TK complexes can be detected in SF from patients with RA if components of the fluids which interfere with the detection of TK are removed. alpha 2-Macroglobulin (alpha 2-M) in SF was demonstrated to contain trapped proteases which were still active in amidase assays. Removal of alpha 2-M from RA SF reduced their amidase activity. However, at least some of the remaining activity was due to TK because it was soya bean trypsin inhibitor resistant and trasylol sensitive and was partly removed by affinity chromatography on anti-TK sepharose. Removal of RF from the fluids reduced the values obtained for TK levels by ELISA. Addition of SF to human urinary kallikrein (HUK) considerably reduced the levels of TK detected suggesting the presence of a TK ELISA inhibitor in the fluids. Removal of components of > 300 kDa from SF markedly reduced the TK ELISA inhibitory activity and increased the values for both the TK and alpha 1-AT/TK levels in fluids as measured by ELISA. It is considered this novel inhibitor does not bind to the active site of TK but rather binds to the site reactive with anti-TK antibodies.

Adult↗
PubMed1994

Absorption of macronutrients from a high-protein diet in children during convalescence from shigellosis.

Absorption of macronutrients and energy intake were determined in 29 children aged 24-59 months, during convalescence from acute shigellosis. A 72 h metabolic balance study was performed to determine the absorption of carbohydrate, fat, and protein. Eighteen children received a high-protein (5 g/kg/day) diet, and 11 children received a standard-protein (2.5 g/kg/day) diet. The mean +/- SD energy intake was 612 +/- 38 kJ/kg/day for children receiving the high-protein diet, compared with 633 +/- 50 kJ/kg/day for the standard-protein group. The coefficient of carbohydrate absorption was 89 and 92% for the high-protein and standard-protein diets, respectively (p = 0.059). The coefficient of protein absorption was 80 and 71% for the high-protein and standard-protein groups, respectively, and was significantly higher in the high-protein group (p < 0.01). Absorption of fat was similar in both groups. The results of the study show better absorption of protein from a high-protein diet during convalescence, which may have a positive impact on catch-up growth of children suffering from shigellosis.

Child, Preschool↗
PubMed1994

Intake from an energy-dense porridge liquefied by amylase of germinated wheat: a controlled trial in severely malnourished children during convalescence from diarrhoea.

OBJECTIVE: To evaluate the role of an energy-dense diet liquefied with amylase-rich flour from germinated wheat (ARF) in increasing the energy intake in severely malnourished infants and young children and its acceptability to mothers. DESIGN: A randomized controlled clinical trial with two sets of controls. SETTING: Nutrition rehabilitation unit of a large diarrhoea treatment centre where mothers stay with their very severely malnourished children. SUBJECTS: 78 severely malnourished children aged 5-18 months just recovered from diarrhoea. INTERVENTION: Children were randomly assigned to receive either an energy-dense porridge made liquid by adding ARF (test diet) or an unaltered thick porridge of similar energy density (control 1 diet), or the porridge made liquid with addition of water to have the same viscosity as the test diet but of lower energy (control 2 diet), in four major meals a day for 5 days and intake was measured; breast-milk was measured by test weighing. Children also received an additional three milk-cereal meals a day. RESULTS: The mean energy intake (95% CI, P value for difference between test and control) was 385 (339-431), 289 (251-327, P < 0.005), and 255 (222-289, P < 0.001) kJ/kg.d respectively. Feeding test diet was not associated with significant adverse effects e.g. on diarrhoea, vomiting, breast-milk intake, and was well accepted by mothers. CONCLUSION: The results suggest that use of an energy-dense ARF-treated liquefied porridge increases calorie intake by very severely malnourished children during convalescence from diarrhoea, and that it does not produce any adverse effect.

Amylases↗
PubMed1994

The effects of cigarette smoking on human gingival tissues (a histopathological study).

Gingival biopsy specimens were obtained from 9 smokers and 7 non-smokers during routine flap surgical procedure to investigate the effects of cigarette smoking on gingival epithelium and connective tissue. Although no remarkable histopathological difference was noted between gingival tissues of smokers and non-smokers, but smokers revealed relatively more epithelial keratosis, inflammatory cells, blood vessels and collagen fibres in connective tissue. Congestion of the capillaries were also more prominent in the smoker's gingival tissues.

Adult↗
PubMed1994

Maternal and socioeconomic factors and the risk of severe malnutrition in a child: a case-control study.

OBJECTIVE: To examine the relation of maternal and socioeconomic factors with the development of severe malnutrition in young children. DESIGN: A case-control study. SETTING: A large diarrhoea treatment centre in a metropolitan city. SUBJECTS: Cases were 125 severely malnourished children, aged < 36 months, having weight-for-age < 55% of the United States National Center for Health Statistics (NCHS) median values. Controls (n = 125) were recruited concurrently matching for gender, disease type (i.e. diarrhoea or dysentery) and age stratum, having weight-for-age > 60% of NCHS median values. INTERVENTION: Mothers of the children were interviewed to record personal history and various socioeconomic variables and examined for height and weight. RESULTS: Maternal factors such as illiteracy, mothers' employment outside, lack of breastfeeding and maternal malnutrition (as indicated by low body mass index, weight or height); and selected socioeconomic indicators such as poor family income, use of unprotected surface water or unhygienic latrine were found to be significantly associated with severe malnutrition in their children. In multivariate analysis, maternal illiteracy and lack of breastfeeding were associated with approximately fourfold increased risk of severe malnutrition in their children. A strong positive association of employment of mothers outside homes with fivefold increased risk was surprising and may reflect a complex social problem of poor urban mothers; malnourished mothers were 2.5 times more likely to have severely malnourished children. CONCLUSION: The findings confirm the well-known association of lack of maternal education and breastfeeding with severe malnutrition of their children. Maternal malnutrition may be a useful indicator to identify at-risk families with severely malnourished children. However, its causal association, though plausible, cannot be inferred from the study.

Breast Feeding↗
PubMed1993

Structural studies of the Vibrio mimicus W-26768 O-antigen polysaccharide.

The structure of the Vibrio mimicus W-26768 O-antigen polysaccharide has been investigated by sugar and methylation analyses, Smith degradation, and NMR spectroscopy. It is proposed that it is composed of chains of beta-(1-->4)-linked 3,6-dideoxy-3-[(R)-3-hydroxybutyramido]-D-glucopyranosyl residues (D-Qui(p)3NR), approximately 60% of which are substituted in the 2-position with 2-acetamido-2-deoxy-alpha-D-galactopyranosyl groups. The polysaccharide does not seem to be composed of oligosaccharide repeating units but has a less regular structure, schematically indicated below. [formula: see text]

Carbohydrate Conformation↗
PubMed1993

Structural studies of Vibrio fluvialis M-940 O-antigen polysaccharide.

The structure of the Vibrio fluvialis M-940 O-antigen polysaccharide has been investigated by sugar and methylation analyses, specific degradations, NMR spectroscopy, and mass spectrometry. It is proposed that it consists of a heptasaccharide unit having the following structure. alpha-L-Rhap-(1-->2)-alpha-L-Fucp-(1-->2)-alpha-D-Galp-(1--> 2)-alpha-L-Fucp- (1-->3)-beta-D-GlcpA-(1-->4)-alpha-L-Rhap-(1-->3)-beta-D-Glc pNAc-(1--> The heptasaccharide is most probably linked to the 3-position of an alpha-D-galactopyranosyl residue in the core.

Carbohydrate Conformation↗
PubMed1993

Rapid catch-up growth of children fed a high-protein diet during convalescence from shigellosis.

Sixty-nine children age 2-5 y, convalescing from shigellosis in a randomized clinical trial were fed either a high-protein diet containing 628 kJ.kg-1.d-1 with 15% of total energy as protein, or a standard-protein diet that was isoenergetic but with 7.5% of total energy as protein for 21 d. Children fed the high-protein diet showed a significant increase in height (1.02 +/- 0.44 cm; mean +/- SD) compared with the children who were fed the standard-protein diet (0.69 +/- 0.34 cm; P < 0.001). Similarly, increases in body weight were 1.25 +/- 0.48 vs 0.86 +/- 0.48 kg for the high-protein and the standard-protein diet, respectively (P < 0.001). The mean increases of serum proteins were also significantly higher in the high-protein group (P < 0.01). These results indicate that increasing the protein content of the diet during convalescence from shigellosis in children leads to more rapid catch-up growth.

Aging↗
PubMed1993

Clonal relationships among classical Vibrio cholerae O1 strains isolated between 1961 and 1992 in Bangladesh.

In Bangladesh, the replacement of classical Vibrio cholerae by the E1 Tor biotype in 1968 and the reappearance of the classical biotype and its coexistence with the E1 Tor biotype after 1982 were never adequately explained. We have analyzed 23 classical V. cholerae isolates collected between 1961 and 1968, 14 classical isolates collected between 1982 and 1992 from the capital city, Dhaka, and 6 classical V. cholerae isolates collected from two southern districts of Bangladesh and studied restriction endonuclease cleavage patterns of rRNA genes (ribotypes) to investigate the clonal relationships among the isolates. Southern blots of total DNA digested with restriction enzyme BamHI, BglI, EcoRI, HindIII, or PstI were probed, using a cloned Escherichia coli rRNA operon. While restriction enzymes BamHI, EcoRI, and PstI failed to differentiate the isolates on the basis of ribotyping, BglI and HindIII produced digestion patterns that allowed differentiation. Ribotyping the isolates with BglI and HindIII revealed five different clones (ribotypes IA, IB, IIA, IC, and IIC) of classical vibrios in Bangladesh. Strains belonging to ribotypes IA and IB were isolated in Dhaka before 1968, and one ribotype (IA) was again isolated between 1982 and 1992. Ribotype IIA was isolated in 1988 and 1989, when both clones (IA and IIA) of classical vibrios coexisted with the EI Tor vibrios. Isolates belonging to ribotypes IC and IIC were collected in the southern districts of Bangladesh and were clearly different from those collected in Dhaka between 1968 and 1992 by ribotyping analysis with BglI. These results support the previous assumption that classical vibrios were never completely replaced in Bangladesh and also demonstrate the existence of more than one genetically different clone of classical V. cholerae.

Bangladesh↗
PubMed1993

National growth rate method with varying internal migration rate.

"The assumption of 'uniform flow of internal migration' used in [the paper by] Rahman (1987) is generalised in this paper for cases when the flow of internal migration is increasing or even decreasing. In particular, the cases when the migration rate is proportional to the national population or to the regional population are analysed. Procedure for estimation of the migration rate and the pure migration are given. The formula for prediction of population is also provided. As an application of the procedure, migration to the Dhaka SMA is analysed with the help of Census data [for Bangladesh]."

Asia↗
PubMed1993

Antibiotic resistance pattern of heat-labile enterotoxin (LT) producing Escherichia coli isolated from children with diarrhoea in Bangladesh: clonal relationships among isolates with different resistant phenotypes.

Fifty-six heat-labile, enterotoxin-producing (LT+) Escherichia coli isolated from 33 children less than 5 years of age with diarrhoea were analysed for resistance to antibiotics, plasmid contents, and clonal relationships among isolates by ribosomal RNA (rRNA) fingerprinting (ribotyping). Fifty-five (98.2%) of the LT+ isolates were resistant either to tetracycline alone (48.2%) or to tetracycline and one or more other antibiotic, i.e. ampicillin, streptomycin, chloramphenicol, trimethoprim-sulfamethoxazole, or nalidixic acid. Most of the isolates harboured one or more plasmid but antibiotic resistance patterns did not always correlate with particular plasmid patterns. Ribotyping of the isolates using the restriction endonuclease EcoRI revealed a total of 7 different ribotypes, and ribotypes were shared by E. coli isolates with different antibiotic resistant phenotypes. The results indicate that in Bangladesh at least 7 different clones of LT+ E. coli acquired resistance to one or more different antibiotics in various combinations. However, a similar drug resistance pattern was not mediated by the same set of plasmids in all strains. The mechanism for the emergence and spread of antibiotic resistance among E. coli should be investigated further in Bangladesh, where LT+ E. coli is an important agent of early childhood diarrhoea.

Bacterial Toxins↗
PubMed1993

Can infants and young children eat enough green leafy vegetables from a single traditional meal to meet their daily vitamin A requirements?

To evaluate the feasibility of providing adequate vitamin A precursors to meet the daily need from a meal oftraditionally cooked green leafy vegetables and boiled rice and to understand mothers' perceptions and acceptance of leafy vegetables for infants and young children, 118 children aged 6 months to 3 years and their mothers were studied. The mothers were interviewed regarding their acceptance and perceptions about giving leafy vegetables to their young children. Their children were served a measured amount of rice and cooked leafy vegetables and mothers were asked to feed the child within about half an hour. Median intakes of leafy vegetables in children aged 6-11 months, 12-17 months and 18-35 months were 41 g, 71 g and 129 g respectively (in terms of raw green leaf). Approximately 40 g green leaf provides the recommended daily allowance for vitamin A precursors. 77% of the under-1-year-old children were breast-fed. The breast-fed children had a lower intake of vegetables than the completely weaned children. 87% of the children were found to like vegetables, 89% of the mothers liked to give vegetables to their children and 74% of the mothers answered that vegetables were good for health. Only two mothers (1.5%) refused to feed their children the leafy vegetables. The results show that leafy vegetables are acceptable to most of the mothers, and that children can eat enough leafy vegetables to meet a day's need of vitamin A precursors. Feasibility of feeding children enough green leafy vegetables at home on a regular basis needs further study.

Bangladesh↗