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Biomedical subjects

M M Rahman

Publications and source records attributed to M M Rahman.

At least 163 records · Page 9Linked to original sources
PubMed1989

Combined effects of acyclovir and human interferon-alpha on herpes simplex virus replication in cultured neural cells.

The combined effects of Acyclovir [9-(2'-hydroxyethoxymethyl)guanine; ACV] and human interferon-alpha (IFN-alpha) on replication of the herpes simplex virus type I (HSV-1) were determined in human neural cell lines, neuroblastoma (IMR), glioblastoma (118MGC), and glioma (U251MG). HSV-1 grew well in all these cells, with final yields of more than 1 x 10(6) PFU/ml. In terms of virus-yield reduction, ACV was found to be highly effective in IMR, moderately effective in U251MG, but ineffective in 118MGC. By contrast, IFN-alpha reduced the virus yield significantly in 118MGC and in U251MG, but did not in IMR. Combined application of ACV and IFN-alpha strongly inhibited the virus replication in all three cell lines with various degrees of synergism or additive effect. These results were also confirmed by immunofluorescent examinations. The sensitivity of HSV-1 to ACV or IFN-alpha was found to be different among the three different cell types. By combining the two agents, the virus growth was strongly suppressed in all the cells. These results suggest the importance of combination therapy for severe type of herpes simplex encephalitis in clinical practice.

Acyclovir↗
PubMed1987

Local production of rotavirus specific IgA in breast tissue and transfer to neonates.

Rotavirus specific IgA, secretory component, and IgG were measured by enzyme linked immunosorbent assay in 20 pairs of mothers and babies to estimate antibody transfer from the mother, particularly from breast milk to neonatal faeces. Colostrum contained high titres of specific IgA and secretory component, which decreased gradually. Faeces after breast feeding for three days showed detectable titres of IgA and secretory component, with further increases by seven days. There was a positive correlation between titres of secretory component in breast milk and in faeces. To clarify the mechanism of high anti-rotavirus activity in breast milk, ratios of rotavirus specific IgA in maternal serum samples to breast milk were calculated and compared with those that were herpes simplex virus specific. Significantly higher concentrations were obtained for the herpes simplex virus specific samples, indicating that anti-rotavirus IgA is selectively produced in breast tissue.

Antibodies, Viral↗
PubMed1987

The prevalence of atypical serum cholinesterase in a Nigerian population.

The prevalence of the atypical phenotype of pseudocholinesterase was looked for in 345 individuals living in Zaria district of Northern Nigeria by the differential inhibitory actions of dibucaine and sodium fluoride. The frequency of the atypical gene, Ea1 was found to be 0.9% and the frequency of the fluoride insensitive phenotype Ef1, was 0.74%. The atypical enzyme or the intermediate phenotype was not observed in any of the 42 patients with sickle-cell disease.

Alleles↗
PubMed1985

Cell mediated immune response following foot-and-mouth disease vaccination in buffalo calves.

The cell mediated immune (CMI) response was studied by E-rosette formation in vitro and delayed type hypersensitivity (DTH) skin reaction in buffalo calves vaccinated with monovalent type 0 as well as with a polyvalent foot-and-mouth disease vaccine. Up to 35 days post-vaccination there was a significant increase (P less than 0.05) in the number of T-lymphocytes in both animal groups. Thereafter, the number of lymphocytes decreased. Delayed type hypersensitivity (DTH) skin reaction was characterized by a significant increase in skin thickness; histology showed mononuclear infiltration and perivascular cuffing.

Animals↗
PubMed1985

An animal model of haemolytic--uraemic syndrome in shigellosis: lipopolysaccharides of Shigella dysenteriae I and S. flexneri produce leucocyte-mediated renal cortical necrosis in rabbits.

To develop an animal model of the haemolytic-uraemic syndrome during shigellosis, rabbits were injected with lipopolysaccharides (LPS) extracted by the hot phenol-water method from Shigella dysenteriae I and from S. flexneri. Two intravenous injections of LPS spaced by 24 h elicited renal cortical necrosis in a generalized Shwartzman reaction characterized by fibrin deposition in glomerular capillaries and by elevated plasma creatinine concentration. Rabbits rendered leucopenic by busulphan treatment were protected against renal cortical necrosis after injection with LPS derived from S. dysenteriae I. Both LPS preparations derived from Shigella species were also active in producing fever in rabbits, death in rabbits, and gelation of limulus lysate with approximately the same potency as a standard LPS of E. coli 055:B5. These results demonstrated that the LPS of Shigella species given intravenously to rabbits produces renal cortical necrosis, which is caused by leucocyte-mediated intravascular fibrin deposition in renal blood vessels and which resembles histologically the renal lesion in the haemolytic-uraemic during shigellosis in humans.

Animals↗
PubMed1975

Study of energy expenditure and food intake of some working class people of Bangladesh.

No information is available on energy expenditure and dietary intake of Bangladesh population carried out simultaneously. As a preliminary step in this direction, forty volunteers mostly from the low socio-economic groups were subjected to these studies for a 3-4 day period. Indirect calorimetric method was used for the measurement of oxygen consumption and energy expenditure. Actual weighing of food articles were carried out before consumption and values calculated from standard tables. It was found that values obtained during rest like sitting and lying including basal metabolic rate (BMR) fell within values reported in the literature. Resting energy expenditure, however, tended to rise in the later part of the day and the degree of physical activity carried out by the subjects. Rickshawpedalling required 6.66 Kcal/min to be expended without passenger and 7.84 Kcal/min with two passengers. Cartpulling required 5.5 Kcal/min without load compared to 6.08 Kcal/min with a load of 350 kg. The small difference was obviously due to a reduction in the speed of cartpulling. This was, however, not true with rickshawpedallers. Dietary intake showed that all the subjects were getting a low protein and low fat diet and that carbohydrates were the main source (over 80%) of calories. The doctors were the only group receiving some animal protein and the cartpullars eating almost none. The number of calories taken were consistent with their activities. One rickshawpedaller had an unusually high intake of over 6000 calories daily.

Adolescent↗