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Biomedical subjects

M M Rodrigues

Publications and source records attributed to M M Rodrigues.

At least 37 records · Page 2Linked to original sources
PubMed1976

Clinicopathologic correlation of microphthalmos with cyst.

Three patients had microphthalmos with cyst in one orbit and contralateral congenital cystic eye, microphthalmos alone, or microphthalmos with cyst. Four eyes were examined histopathologically. The microphthalmic eye demonstrated a spectrum of anterior segment abnormalities, retinal disorganization and gliosis, and a choroidal and scleral colomboma. The cyst connected to the colobona consisted of an outer fibrovascular layer and inner gliotic neuroectodermal layer. The cyst probably originated from proliferation of neuroectodermal tissue at the edge of a persistently open embryonic fissure. Treatment consisted of multiple aspirations of the cyst, excision of the cyst alone, and excision of both the microphthalmic eye and cyst.

Abnormalities, Multiple↗
PubMed1976

Spheno-orbital meningioma with optociliary veins.

A 40-year-old white woman had slowly progressive unilateral loss of visual acuity and increasing proptosis during an eight-year period. Ophthalmoscopy and fluorescein angiography revealed chronic disk edema and optociliary shunt vessels in the right eye. Polytomography showed an enlarged right optic canal. Cerebral arteriography demonstrated a dumbbell-shaped tumor blush in the right juxtasellar region and a diffuse tumor blush in the right orbit. Right frontal craniotomy and orbital exploration showed a cranio-orbital junction (spheno-orbital) meningioma that invaded the sclera and peripapillary choroid. Anomalous optociliary veins were demonstrated histologically at the optic disk.

Adult↗
PubMed1976

Alterations of Descemet's membrane in interstitial keratitis.

Twenty corneas from patients with interstitial keratitis were examined by light microscopy and one of these by electron microscopy. Seventy percent of patients had either a positive serologic test for syphilis or a history of treatment for syphilis. Focal or diffuse multilaminar thickening of Descemet's membrane with secondary linear guttata was present in 88% of cases. Confluent linear cornea guttata formed retrocorneal hyaline ridges that clinically showed a central gray core surrounded by a translucent sheath. Microscopically, these ridges consisted of concentric laminations of newly formed Descemet's membrane. Some ridges hung into the anterior chamber as a bow-like strand or a spiderweb network. A possible pathogenetic sequence may include (1) inflammatory insult to a relatively young endothelium; (2) alteration of endothelial function to fibroblast-like activity; (3) the production of abnormal basement membrane and other collagenous material and formation of a new multilaminar Descemet's membrane; and (4) separation of some ridges from the multilaminar Descemet's membrane to hang into the anterior chamber as strands and networks.

Anterior Chamber↗
PubMed1976

Juvenile glaucoma associated with goniodysgenesis.

Clinicopathologic studies, including electron microscopy, of trabeculectomy and peripheral iridectomy specimens from three patients with "juvenile" glaucoma revealed varying forms of maldevlopment of the chamber angle in all cases. A 20-year-old white woman (Case 1) had associated iridogoniodysgenesis with a pseudopolycoria-like iris pattern. In a 39-year-old white woman (Case 2), goniodysgenesis was associated with degenerated cell remnants in the angle "cleavage" area. A 15-year-old mentally retarded white boy (Case 3) displayed features of juvenile pigmentary glaucoma with associated goniodysgenesis and megalocornea.

Adolescent↗
PubMed1976

Unusual eyelid involvement in tuberous sclerosis.

A two-week-old male infant had a nodular salmon-colored lesion on his right lower eyelid and hypopigmented mascular lesions on the abdomen and right thigh since birth. At five months of age he developed a generalized seizure disorder. Histologic examination of the eyelid lesion revealed an angiofibroma, which was an unusual initial site of involvement in tuberous sclerosis.

Collagen↗
PubMed1976

Malignant melanoma of the choroid with balloon cells a clinicopathologic study of three cases.

We report the findings on clinicopathologic examination of three patients with balloon cell melanoma of the choroid. Ophthalmoscopically, all three had small, slowly progressive tumors at the posterior pole, with an encircling yellow halo. With fluorescein angiography, the yellow halo showed fluorescence similar to the remainder of the tumor, thus differentiating this substance from lipofuscin pigment, drusen and exudates. Light microscopy demonstrated prominent balloon cells which were most numerous at the tumor margins. These cells showed variable melanin pigmentation and were negative for lipid, acid mucopolysaccharide, and glycogen. Special enzyme studies (lactic dehydrogenase, succinic dehydrogenase, acid phosphatase, beta glucoronidase and aminopeptidase) demonstrated some similarity to melanocytic cells. Electron microscopy revealed premelanosomes and complex melanosomes in the cytoplasm of balloon cells without evidence of significant lipid.

Acid Phosphatase↗
PubMed1976

Orbital amyloidosis.

A 51-year-old male presented with a chronic asymmetrical ptosis which was variable. Repeated anticholinesterase testing gave equivocal responses. The patient was treated for myasthenia gravis until a mass was detected in the orbit. Although rare, localized orbital amyloidosis should be considered in the diagnosis of patients with ptosis, particularly when the results of anticholinesterase testing are equivocal.

Amyloidosis↗
PubMed1975

Corneal elastosis. Appearance of band-like keratopathy and spheroidal degeneration.

Clinical and pathologic studies of six corneas from patients with band-like keratopathy and spheroid degeneration were performed. These included cases of noncalcific band keratopathy; in one case very early changes in Bowman membrane were demonstrated by light and electron microscopy. Two other corneas displayed more advanced degeneration that manifested clinically as irregular golden yellow plaques. One case of corneal spheroid degeneration was associated with lattice dystrophy of the cornea. The corneal deposits may be best characterized as a form of elastotic degeneration and were associated with intense autofluorescence.

Adolescent↗
PubMed1975

Exogenous corneal ulcer caused by Tritirachium roseum.

A 29-year-old white man developed a corneal ulcer following trauma to his left cornea by a piece of wire. Tritirachium roseum, a saprophytic fungus, was cultured from corneal scrapings and demonstrated in the corneal button by histopathologic examination.

Adult↗
PubMed1975

Endothelial alterations in congenital corneal dystrophies.

We studied the clinical and ultrastructural findings in three different types of congenital endothelial dystrophies: hereditary posterior polymorphous dystrophy, congenital hereditary corneal dystrophy, and a nonhereditary congenital endothelial dystrophy. In the first patient, with hereditary posterior polymorphous dystrophy, a layer of epithelial-like cells was observed adjacent to endothelial cells on the posterior corneal surface. Descemet's membrane displayed a multilaminar pattern and consisted of an anterior, thin (3 mu), PAS-positive layer and a posterior, thicker (25 to 30 mu) zone of abnormal collagen. The second patient, with congenital hereditary endothelial dystrophy, showed a thickened multilaminar Descemet's membrane and scant endothelial cells. In the third patient with nonhereditary congenital endothelial dystrophy, the thickened Descemet's membrane was lined posteriorly by a retrocorneal fibrous membrane. A few degenerated endothelial cells were present. All three cases showed 100- to 110-nm banding posteriorly. In these three clinically distinct entities, electron microscopy was useful in demonstrating the unusual form of endothelial transformation to epithelial-like cells in one patient, in contrast to the more common fibroblast-like metaplasia of endothelial cells seen in the other two patients.

Adolescent↗
PubMed1975

Corneal clouding with increased acid mucopolysaccharide accumulation in Bowman's membrane.

Two infants had bilateral congenital corneal clouding and abnormal acid mucopolysaccharide accumulation in a thickened Bowman's membrane. This unusual entity was not associated with acid mucopolysaccharide deposits in the skin and visceral tissues or with increased levels of acid mucopolysaccharide in the urine. The similarity and differences have been compared to the systemic mucopolysaccharidosis and macular corneal dystrophy.

Basement Membrane↗
PubMed1975

Retinal pigment epithelium in incontinentia pigmenti.

An 18-month-old white girl with incontinentia pigmenti presented clinically with leukokoria of the right eye. B-scan ultrasound demonstrated a retrolental mass consistent with a detached retina. Histologic examination of the skin revealed changes compatible with the intermediate verrucous phase of the disease. Microscopic examination of the right eye showed retinal detachment and nodular proliferation of the retinal pigment epithelium. The nodules contained macrophages laden with melanin and lipofuscin. An unusually large amount of lipofuscin was present for a child of this age. The basic pigmentary abnormality may affect the retinal pigment epithelium, resulting in changes in the overlying neurosensory retina that may lead to the retinal dysplasia or retinal detachemnt often associated with this condition.

Cataract↗
PubMed1975

Exogenous fungal endophthalmitis caused by Paecilomyces.

A 17-year-old white boy developed a fulminating corneal infection and endophthalmitis in his left eye after trauma. He was treated with antibiotics and corticosteroids for one week prior to diagnosis. A saprophytic fungus, Paecilomyces viridis, was cultured from corneal scrapings and was demonstrated in the vitreous cavity by histopathologic examination.

Adolescent↗