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Biomedical subjects

M M Sharma

Publications and source records attributed to M M Sharma.

11 recordsLinked to original sources
PubMed1992

Herbert screw: results of a single-centre trial.

We report the results of a single-centre trial of the Herbert screw in the treatment of acute fractures, fracture-dislocations and non-unions of the carpal scaphoid. In the trial, 22 patients were studied with a maximum follow-up of 2.5 years. Of the patients, 84 per cent had minimal or no pain, and 94 per cent were happy with their result or significantly improved. There was an average loss of 34 per cent of radial deviation of the wrist and of 10 per cent in cylinder grip strength. On radiographic examination, 86 per cent achieved satisfactory union. However, only 73 per cent of type D2 fractures united. Overall, the subjective and objective clinical results achieved were more satisfactory than the radiographic results would suggest.

Adult↗
PubMed1992

Surface-active compounds from microorganisms.

Microbial surfactants are a structurally diverse group of compounds consisting of hydrophilic and hydrophobic domains and which partition preferentially at interfaces. Biosurfactants are of increasing interest commercially as substitutes for synthetic surfactants particularly for environmental applications. This article discusses recent progress in the genetic and biochemical analysis of biosurfactant synthesis as well as the current status of fermentation technologies.

Bacteria↗
PubMed1979

Efficacy of metronidazole in dracunculiasis. A clinical trial.

In a clinical trial of metronidazole for dracunculiasis (75 cases), the drug was effective in giving symptomatic relief but had no preventive or vermicidal action. It was well tolerated. No difference was observed in the results of two dose schedules (200 mg or 400 mg three times daily for 10 days).

Dracunculiasis↗
PubMed1978

Pancreatic hypersecretion in liver disease.

Abnormally large duodenal aspirates have been reported in a large percentage of patients with cirrhosis of the liver. The source of this fluid has been variously ascribed to the liver and/or pancreas. The present study was undertaken to clarify its source. Eleven patients with cirrhosis of the liver and one with cholestatic hepatitis underwent an intraductal secretin test during endoscopic cannulation of the pancreatic duct. Six patients with cirrhosis had pancreatic hypersecretion ranging from 7.8 to 26.0 ml/min, while three patients demonstrated low secretory flow rates. Bile flow was negligible or nonexistent in ten patients, while in two others, larger but unmeasurable amounts of bile secretion were present. This study conclusively demonstrates that pancreatic hypersecretion may occur in patients with cirrhosis during secretin stimulation. Impaired metabolism of secretin or the associated pancreatic hypersecretion of early pancreatitis may be responsible for this finding.

Bile↗
PubMed1978

Endoscopic measurement of pancreatic juice secretory flow rates and pancreatic secretory pressures after secretin administration in human controls and in patients with acute relapsing pancreatitis, chronic pancreatitis, and pancreatic cancer.

Secretory flow rates were measured inside the main pancreatic duct during endoscopic retrograde cholangiopancreatography (ERCP) in patients with acute relapsing pancreatitis, chronic pancreatitis, and pancreatic cancer and in controls after intravenous administration of secretin. Peak secretory flow rates in these groups were 5.04 +/- 1.74, 0.71 +/-1.28, 0.60 +/- 1.37, and 4.13 +/- 0.88 ml/min, respectively. Peak secretory pressures were also measured intraductally in patients with acute relapsing pancreatitis and pancreatic cancer and in controls and were 402 +/- 69, 75 +/- 161, and 403 +/- 99 mm pancreatic juice, respectively. Peak secretory flow rates and pressures measured in controls during constant administration of secretin were similar to those measured when secretin was administered as a bolus.

Endoscopy↗
PubMed1975

Splenic-gonadal fusion.

Various aspects of splenic-gonadal fusion are discussed and 1 case of the continuous type is reported. A plea is made to include this condition in the differential diagnosis of scrotal masses, particularly those on the left side.

Adolescent↗
PubMed1975

Primary actinomycosis of the abdominal wall.

A rare case of primary actinomycosis of the abdominal wall presenting as a tumour is described. The patient responded to penicillin therapy well. A brief account of the literature is included.

Abdominal Muscles↗