Biomedical subjects

M M Vilenchik

Publications and source records attributed to M M Vilenchik.

At least 19 recordsLinked to original sources

PubMed1989

Studies of DNA damage and repair of thermal- and radiation-induced lesions in human cells.

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Adult↗

PubMed1989

[The carcinogenic effect of 5-bromodeoxyuridine and its amplification by x-rays in rats].

5-bromodeoxyuridine (BUdR) injected to rats in the neonatal period is shown to produce a pronounced carcinogenic effect which brings about the appearance of various benign and malignant tumours. Exposure of females to X-ray total-body irradiation (1.5 Gy) was followed by intensification of the carcinogenic effect of BUdR. Assuming that this pyrimidine analog reacts solely with DNA substituting thymidine during DNA synthesis and induces point mutations due to tautomerization, the data obtained demonstrate the possibility of tumour induction by a selective DNA perturbation.

Animals↗

PubMed1988

[Effects of beta-carotene on genotoxic lesions in the liver under formation and action of carcinogenic N-nitrosodimethylamine].

beta-carotene pretreatment of rats decreased the methylation and formation of single-strand breaks in DNA and also decreased activity of alanine-aminotransferase, sorbitol dehydrogenase, gamma-glutamyl transpeptidase activities, caused by action of N-nitrosodimethylamine or synthesis of this carcinogen from precursors.

Alanine Transaminase↗

PubMed1981

[DNA from the tissues of aging rats has a circular dichroism spectrum analogous to the spectrum of gamma-irradiated DNA].

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Aging↗

PubMed1979

[Method of lysing animal cells grown on slides on top of an alkaline saccharose gradient].

A device is described providing for lysis of cells grown on glass slides, directly on the top of sucrose gradient. The device allows to avoid cell removing with trypsin, EDTA or due to scraping. The possibility to use this method in studying DNA damage and repair processes in cultured animal cells has been shown using diploid human fibroblasts.

Animals↗

PubMed1979

[Diminished capacity for repair of single-strand breaks in DNA in fibroblasts of adult humans as compared to embryonal fibroblasts].

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Adult↗

PubMed1977

Evidence for unscheduled DNA synthesis in rat brain.

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Age Factors↗

PubMed1976

[DNA synthesis in rat brain nerve cells].

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Aging↗

PubMed1976

[DNA synthesis in the brain and liver of rats in various stages of postnatal development].

The intensity of incorporation of 3H- and 14C-thymidine in the brain and liver DNA in rats of different ages was investigated. It was proved that both the replicative and oxyurea-resistant DNA synthesis might proceed in the rat brain cells. The intensity of these processes changes sharply during postnatal development.

Age Factors↗

PubMedDate not supplied

[Role of DNA repair disorders in chromosome instability, decreased longevity and neoplastic cell transformation in hereditary human diseases].

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Anemia, Aplastic↗

PubMedDate not supplied

[Radioprotective action of natural carotene-containing preparations: research on karotinil in white rats].

Evidence was obtained that beta-carotene injected to rats subcutaneously or per os two times, 4 h and 19 h, before irradiation reduced their death rate from acute affection. The effect was almost invariable with the drug administered either before or after irradiation. The radioprotective efficacy of beta-carotene was attributed to its ability to scavenge active oxygen forms.

Acute Disease↗

PubMedDate not supplied