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M M Winnicka

Publications and source records attributed to M M Winnicka.

At least 19 recordsLinked to original sources
PubMed2001

6-Hydroxydopamine infusions into the structures of mesolimbic dopaminergic system alter the memory enhancing effect of CK-8US and caerulein in rats.

The influence of bilateral destruction of dopaminergic endings in the anterior and in the posterior part of nucleus accumbens (NAS) and in the nucleus septi lateralis (NSL), by 6-hydroxydopamine (6-OHDA) infusions, on the facilitatory effect of cholecystokinin-unsulfated octapeptide (CCK-8US) and caerulein (CER) on memory motivated affectively was investigated in male Wistar rats. CCK-8US and CER were given s.c. at the doses of 10 microg/kg and 0.5 microg/kg respectively, immediately after a single learning trial in a passive avoidance situation, ten days after bilateral 6-OHDA lesions (desipramine pre-treatment; 25 mg/kg, i.p.) of these structures. Bilateral 6-OHDA lesions to the anterior and to the posterior part of NAS totally abolished and significantly attenuated, respective, the facilitatory effect of CCK-8US and CER on retention of a passive avoidance behaviour evaluated 24 h later, while bilateral lesions to NSL did not have any influence on it. Moreover, neither, destruction of dopaminergic endings in lesioned structures, nor application of CCK-8US and CER changed the spontaneous psychomotor activity of rats estimated in an "open field" test. These results may indicate that dopaminergic projection to the anterior part of NAS is mainly responsible for the facilitatory effect of CCK-8US and CER on memory motivated affectively.

Animals↗
PubMed2000

Bilateral 6-OHDA lesions to the hippocampus attenuate the facilitatory effect of CCK-8 us and caerulein on memory in rats.

The involvement of dopaminergic projection to the hippocampus in the facilitatory effect of cholecystokinin-unsulphated octapeptide (CCK-8 us) and caerulein (CER) on memory motivated affectively was investigated in male rats. CCK-8 us and CER were given subcutaneously at the doses of 10 microg kg(-1)and 0.5 microg kg(-1), respectively, immediately after a single learning trial in a passive avoidance situation, after bilateral 6-OHDA lesions to the dentate gyrus of the hippocampus. In order to protect noradrenergic neurones against destruction by neurotoxin, 30 min before surgery rats were pre-treated intraperitoneally with 25 mg kg(-1)of desmethylimipramine, an inhibitor of noradrenaline uptake. Bilateral 6-OHDA lesions to the hippocampus significantly attenuate the facilitatory effect of CCK-8 us and CER on retention of passive avoidance behaviour evaluated 24 h after the learning trial. Neither, destruction of dopaminergic endings in the hippocampus, nor application of CCK-8 us and CER changed the spontaneous psychomotor activity of rats estimated in an 'open field' test. These results may indicate that the facilitatory effect of CCK-8 us and CER on memory motivated affectively is, in part, mediated by dopaminergic projection from the ventral tegmental area to the dentate gyrus of the hippocampus.

Animals↗
PubMed1999

Bilateral transections of temporo-entorhinal connections attenuate vasopressin improvement of memory in rats.

It has been found in our laboratory that the positive influence of vasopressin (AVP) on memory processes is mediated by excitatory amino acids, since it was abolished by NMDA receptor antagonists. The purpose of the present study was to investigate whether bilateral transections of glutamatergic temporo-entorhinal connections may have an influence on the facilitatory effect of AVP on retrieval process of a passive avoidance behaviour. The bilateral transections of temporo-entorhinal connections were made in male Wistar rats 10 days before testing of the influence of intracerebroventricular AVP (1 microgram per rat) injection on memory, evaluated in a passive avoidance task. Although AVP significantly facilitated the retrieval process both in sham-operated and in lesioned groups of rats, bilateral disruption of temporo-entorhinal connections significantly attenuated the facilitatory effect of AVP on the retrieval process. Moreover, bilateral transections of temporo-entorhinal connections failed to affect motor activity, such as crossings of squares, without an influence on rearings and bar approaches evaluated in an open field test. These results may suggest that in the facilitatory effect of AVP on the retrieval process is involved a reciprocal glutamatergic connection between the lateral entorhinal cortex and the temporal cortex.

Animals↗
PubMed1999

Disruption of temporo-entorhinal connections abolishes the facilitatory effect of angiotensins on memory in rats.

It has been found in our laboratory that the positive influence of angiotensin II (AII) and its 3-7 fragment [AII(3-7)] on learning and memory processes is mediated by the excitatory amino acids, since it was abolished by NMDA receptor antagonists. The purpose of the present study was to investigate whether bilateral disruption of glutamatergic temporo- entorhinal connections may have an influence on the facilitatory effect of both angiotensin peptides on memory motivated affectively. The bilateral transections of temporo-entorhinal connections were made in 27 male rats 10 days before testing the influence of intracerebroventricular AII and AII(3-7) injection on retrieval of a passive avoidance response. Twenty-seven additional rats served as sham-operated controls. Twenty-five lesioned and 25 sham-operated animals were accepted to the final analysis. AII and its 3-7 fragment significantly improved the retrieval process in sham-operated groups of rats. Bilateral disruption of temporo-entorhinal connections totally abolished the facilitatory effect of both angiotensins on recall of information in a passive avoidance situation. Moreover, bilateral disruption of temporo-entorhinal connections markedly but not significantly attenuated crossings of squares, evaluated in an open field test, without an influence on rearings and bar approaches. These results may suggest that in the facilitatory effect of AII and AII(3-7) on memory motivated affectively involves reciprocal glutamatergic connection between lateral entorhinal cortex and temporal cortex.

Angiotensin II↗
PubMed1999

Dopaminergic projection to the central amygdala mediates the facilitatory effect of CCK-8US and caerulein on memory in rats.

The involvement of dopaminergic projection to the central amygdala in the facilitatory effect of cholecystokinin unsulphated octapeptide (CCK-8US) and caerulein (CER) on memory motivated affectively was investigated in male rats. CCK-8US and CER were administered subcutaneously at the doses of 10 micrograms kg-1and 0.5 microgram kg-1, respectively, immediately after a single learning trial in a passive avoidance situation, after bilateral 6-OHDA lesions to the central amygdala. Bilateral 6-OHDA lesions to the central amygdala totally abolished the facilitatory effect of CCK-8US and CER on retention of passive avoidance behaviour evaluated 24 h after the learning trial. These results may indicate that the facilitatory effect of CCK-8US and CER on memory motivated affectively is mediated by dopaminergic projection from ventral tegmental area to the central amygdala.

Amygdala↗
PubMed1999

Dopaminergic projection to the nucleus accumbens mediates the memory-enhancing effect of angiotensins in rats.

It has been shown that the facilitatory effect of angiotensin II (AII) and its 3-7 fragment [AII(3-7)] on cognitive processes is mediated by the dopaminergic system. In the present study, the involvement of dopaminergic projection to the nucleus accumbens (NAS) and to the nucleus septi lateralis (NSL) in the expression of the positive effect of AII and AII(3-7) on the retrieval of passive avoidance after bilateral 6-OHDA induced lesions to NAS and NSL was evaluated. To protect noradrenergic neurons from destruction by neurotoxin, rats were pretreated intraperitoneally with 25 mg/kg of desmethylimipramine, an inhibitor of noradrenaline uptake, 30 min before surgery. Both peptides were given intracerebroventricularly, at the dose of 1 nmol each, 15 min before the retention testing. Bilateral 6-OHDA lesions to NAS totally abolished, and to NSL did not affect, the positive effect of angiotensins on recall of information in a passive avoidance situation. Moreover, bilateral 6-OHDA lesions to NAS but not to NSL significantly attenuated the locomotor activity of rats in an open-field test. Nevertheless, it had no essential significance on the evaluation of the influence of the disruption of the dopaminergic endings in both structures on the facilitatory effect of angiotensins on retrieval process. These results suggest that the dopaminergic projection to NAS, but not to NSL is involved in the expression of the facilitatory effect of AII and AII(3-7) on memory motivated affectively evaluated in a passive avoidance situation.

Angiotensin II↗
PubMed1999

Disruption of temporo-entorhinal connections abolishes recognition memory-enhancing effect of angiotensins in rats.

In our laboratory, the positive influence of angiotensin II and its 3-7 fragment on learning and memory processes was found to be mediated by excitatory amino acids, because it was abolished by N-methyl-D-aspartate (NMDA) receptor antagonists. The purpose of the present study was to investigate whether bilateral disruption of glutamatergic temporo-entorhinal connections may have an influence on the facilitatory effect of both angiotensin peptides on recognition memory. The bilateral transections of temporo-entorhinal connections were made in 32 male rats 10 days before testing the effect of intracerebroventricular AII or AII(3-7) injection on the recognition of objects evaluated in an object-recognition test. Thirty additional rats served as sham-operated controls. The final analysis was based on 29 lesioned and 26 sham-operated animals. AII and its 3-7 fragment significantly improved object recognition in the sham-operated groups of rats. Bilateral disruption of temporo-entorhinal connections totally abolished the facilitatory effect of both angiotensins on object recognition. Moreover, bilateral disruption of temporo-entorhinal connections significantly attenuated crossings of squares and rearings, without affecting bar approaches and defecation evaluated in an open-field test. These results may suggest that the facilitatory recognition memory effect of AII and AII(3-7) requires a reciprocal glutamatergic connection between the lateral entorhinal cortex and the temporal cortex.

Angiotensin II↗
PubMed1998

6-OHDA bilateral lesions to the nucleus septi lateralis attenuate vasopressin improvement of recall in rats.

The investigation was aimed at investigating whether the dopaminergic projection arriving at the nucleus septi lateralis (NSL) is involved in the facilitatory effect of vasopressin (AVP) on memory retrieval. The bilateral 6-OHDA lesions to the NSL were made in 20 male Wistar rats before testing the intracerebroventricular (i.c.v.) AVP injection on recall in a passive avoidance situation. Eighteen additional rats served as sham-operated controls. Thirty minutes before surgery rats were pre-treated with an intraperitoneal injection of 25 mg kg-1 of desmethylimipramine, an inhibitor of norepinephrine uptake. Sixteen lesioned and 16 sham-operated rats were included in the study. AVP (1 microgram, i.c.v.) given 15 min before the retention testing significantly improved latencies both in lesioned and in sham-operated rats in comparison with the respective i.c.v. saline-injected animals. However, bilateral lesions to the NSL significantly diminished the facilitatory effect of AVP on recall. The insignificant decrease of spontaneous psychomotor activity in rats lesioned to the NSL was unlikely to interfere with the cognitive effect of AVP. These results suggest that dopaminergic projection to the NSL is involved in the facilitatory effect of AVP on the retrieval process in a passive avoidance situation.

Animals↗
PubMed1998

6-OHDA bilateral lesions to the amygdala abolish the memory enhancing effect of angiotensin II in rats.

The involvement of a dopaminergic projection arriving at the central amygdala (CA) in angiotensin II (AII) facilitation of affectively motivated memory was investigated in male rats. AII was given intracerebroventricularly at a dose of 1 nmol, 15 min before retention testing in a passive avoidance situation after bilateral 6-OHDA lesions to CA. In order to protect noradrenergic neurones against destruction by neurotoxin, 30 min before surgery rats were pre-treated intraperitoneally with 25 mg kg-1 of desmethylimipramine, an inhibitor of noradrenaline uptake. Bilateral 6-OHDA lesions to CA totally abolished the facilitatory effect of AII on the retrieval process in a passive avoidance situation, but had no influence on the spontaneous psychomotor activity of rats. These results suggest that the anatomical substrate facilitating the retrieval of the information activity of AII is closely related to the dopaminergic projection arriving at CA.

Amygdala↗
PubMed1998

6-OHDA lesions to amygdala and hippocampus attenuate memory-enhancing effect of the 3-7 fragment of angiotensin II.

We have previously shown that facilitatory effect of angiotensin II (AII) on the retrieval of memory is mediated by the dopaminergic system. In the present study, we searched for the influence of the 3-7 fragment of angiotensin II [AII(3-7)] on the retrieval processes in a passive avoidance situation after bilateral 6-OHDA lesions to the central amygdala (CA) and the CA4 field of the hippocampus (HI). AII(3-7) given 15 min before the retention testing, at the intracerebroventricular dose of 1 nmol, significantly prolonged avoidance latencies in sham-operated rats (i.e. improved retrieval of memory for the electric footshock experienced during the learning trial). Bilateral lesions to CA totally abolished, and to HI significantly diminished, this facilitatory effect. An increase of spontaneous locomotor activity in rats lesioned to CA and a decrease in rats lesioned to HI were unlikely to interfere with the cognitive effect of AII (3-7). These results suggest that the anatomical substrate of facilitating retrieval of information activity of AII(3-7) is closely related to the dopaminergic projection from the ventral tegmental area and substantia nigra to CA and HI.

Adrenergic Agents↗
PubMed1997

Dopaminergic projection to the septum mediates facilitatory effect of angiotensins on recognition memory in rats.

We have previously reported that the dopaminergic projection from A10 ventral tegmental neurons to the central amygdala is, in part, responsible for the facilitatory effect of angiotensin II (AII) and its 3-7 fragment [AII(3-7)] on the retrieval of information in memory motivated affectively and also on recognition memory. In this study, the influence of both angiotensins, given intracerebroventricularly at the dose of 1 nmol each, in rats lesioned with 6-OHDA to the nucleus accumbens septi (NAS) and to the nucleus septi lateralis (NSL) on recognition memory was evaluated. AII and its 3-7 fragment significantly improved object recognition in sham-operated to NAS and to NSL groups of rats. Bilateral 6-OHDA lesions to NAS totally abolished and to NSL significantly attenuated the facilitatory effect of both angiotensins on object recognition. These results suggest that the dopaminergic projection arriving to the septal structures. NAS and NSL takes part in the facilitatory effect of angiotensins on recognition memory.

Angiotensin II↗
PubMed1997

6-OHDA lesions to the central amygdala abolish angiotensins facilitation of object recognition in rats.

1. We have previously reported that the dopaminergic projection from A10 ventral tegmental neurons and A9 neurons of substantia nigra to the central amygdala (CA) is, in part, responsible for the facilitatory effect of angiotensin II (AII) and its 3-7 fragment [AII(3-7)] on the retrieval of information in memory that is motivated affectively. 2. In this study, the influence of both angiotensins, given intracerebroventricularly at the dose of 1 nmol each in rats lesioned with 6-OHDA to CA, on recognition memory, was tested. 3. AII and its 3-7 fragment significantly improved object recognition in sham-operated groups of rats. Bilateral 6-OHDA lesions to CA totally abolished the facilitatory effect of both angiotensins on object recognition. As insignificant increase of spontaneous locomotor activity in rats lesioned to CA did not interfere with the cognitive effect of AII and AII(3-7). 4. These results suggest that the dopaminergic projection at the CA takes part in the facilitatory effect of angiotensins on recognition memory.

Amygdala↗
PubMed1997

CGP 42112A abolishes facilitation of recognition caused by angiotensin II and angiotensin II(3-7) in rats.

The role of the angiotensin AT2 receptors in some behavioural effects of angiotensin II (Ang II) and its 3-7 fragment [Ang II(3-7)], using their selective antagonist CGP 42112A, was assessed. Ang II and Ang II(3-7), given intracerebroventricularly (icv) at the dose of 1 nmole each, substantially improved object recognition memory and enhanced apomorphine (1 mg/kg) stereotypy. Pre-treatment of rats with CGP 42112A (2 micrograms), per se ineffective in all tests, abolished activity of both peptides. None of the treatments significantly changed behaviour of rats in open field. The results point to the considerable involvement of the AT2 angiotensin receptors in the improvement of recognition memory caused by Ang II and Ang II(3-7).

Angiotensin II↗
PubMed1996

6-OHDA bilateral lesions to the central amygdala do not affect vasopressin improvement of recall in rats.

The influence of vasopressin (AVP) on recall of information in a passive avoidance situation after bilateral 6-OHDA lesions to the central amygdala was tested. AVP given 15 min before the retention testing at the icv dose of 1 microgram significantly prolonged avoidance latencies both in lesioned and in sham-operated rats in comparison with the respective icv saline injected animals. Insignificant increase of spontaneous locomotor activity in rats lesioned to the central amygdala was unlikely to interfere with the cognitive effect of AVP. These results suggest that dopaminergic projection to the central amygdala is not responsible for the facilitatory effect of AVP on retrieval process in a passive avoidance situation.

Amygdala↗
PubMed1996

Solcoseryl improves learning and memory in rats.

Our previous experiments have shown that Solcoseryl (S), a protein-free extract of calves' blood stimulates locomotor activity and decreases haloperidol catalepsy in rats. In this study the influence of S on acquisition, consolidation, and recall of both, conditioned avoidance responses (CARs) and passive avoidance behaviour was tested. S at the intraperitoneal (i.p.) dose of 1.25 ml/kg significantly improved acquisition and at the dose of 1.0 ml/kg recall of CARs. In the passive avoidance situation the significant effect on acquisition and recall of information was observed after i.p. injection of 1.0 ml/kg of S, and on consolidation after 0.75 ml/kg. These data indicate that S may positively affect the CNS processes responsible for learning and memory.

Actihaemyl↗
PubMed1996

Solcoseryl stimulates behavioural activity of rats.

The influence of Solcoseryl (S), a protein-free extract of calves' blood given intraperitoneally (i.p.) on the behavioural measures of activity of the central nervous system of male Wistar rats was examined. The drug (1.0 ml/kg i.p.) given 60 min before testing the animals in electromagnetic motimeter significantly enhanced overall and vertical motility of rats. S at the doses of 0.5, 1.0 and 2.0 ml/kg did not significantly influence the activity of rats in "open field". 1.0 ml/kg of S given 15, 45 and 60 min before thiopental (30 mg/kg i.p.) did not change the onset and time of sleep following the latter drug, except for the significant shortening of the time of sleep of animals injected with S 15 min before thiopental. S at the dose of 1.0 ml/kg did not change stereotypies produced by apomorphine (2.0 mg/kg i.p.) and amphetamine (6.5 mg/kg i.p.) but decreased intensity of haloperidol (1.0 mg/kg i.p.) catalepsy.

Actihaemyl↗
PubMedDate not supplied

6-OHDA lesion to the entorhinal cortex does not abolish angiotensin II improvement of recall in rats.

Our recent studies have shown that facilitating effect of angiotensin II (AII) on recall is mediated by dopaminergic systems. In this study the influence of bilateral destruction of dopaminergic endings in the entorhinal cortex on improving recall intracerebroventricular injection of AII was tested. Since this lesion did not abolish the facilitating influence of AII, it may be suggested that the dopaminergic projection to the entorhinal cortex is not responsible for the facilitating effect of AII on recall in a passive avoidance situation.

Angiotensin II↗