Biomedical subjects

M M Wysocka-Bakowska

Publications and source records attributed to M M Wysocka-Bakowska.

7 recordsLinked to original sources

PubMed1992

A new hereditary syndrome with a bleeding tendency, extreme miosis, spasms, dyslexia, thrombocytopathia etc. Pupillometric, evaporimetric, and ophthalmological observations.

A recently described familiar syndrome consists of the following components: A bleeding tendency with thrombocytopathia, miosis, muscular weakness and spasms, ichthyosis, asplenia, dyslexia, and headache. Four definite and 2 probable patients have been identified in 4 generations. In the present study, the pupillary behaviour was scrutinized in two 'definite' cases with the infrared, binocular pupillometer. The forehead sweating pattern was also investigated with an Evaporimeter. The basal pupillary widths were: 1.25-1.75 mm. Only minor responses were noted upon topical stimulation with an indirectly acting pupillodilating agent (OH-amphetamine). A directly acting sympathicomimetic drug (phenylephrine) exerted a more marked influence on the pupil, indicating a relative supersensitivity. The evaporimetric pattern in the forehead seemed to be within reference limits, at variance with what is the case in Horner's syndrome. Further findings were: the orbit seemed to be smaller than normal; a bilateral VI. cranial nerve palsy was identified, and a marked upward gaze palsy coexisted with pupils with Argyll Robertson's traits. There is no readily acceptable explanation for the ocular abnormalities. The disorder underlying the pupillary abnormality may possibly be located in the upper mesencephalon.

Adult↗

PubMed1988

Cervicogenic headache. Pupillometric findings.

Eleven female patients with cervicogenic headache (mean age, 43 years; range, 25-59 years) have been examined with the pupillometer. The pupillary diameter was examined in the basal state (that is, the status before pharmacologic stimulation) and after topically administered tyramine (2%), phenylephrine (1%), and hydroxyamphetamine (1%). A total of 51 tests were performed, 35 in the asymptomatic period and 16 during pain attacks. In a control group consisting of 26 age-matched women a total of 39 tests were carried out. Before pharmacologic stimulation (that is, in the "basal state") the pupils were smaller in the asymptomatic (pain-free) period than during pain attacks in the patients and also as compared with that of control individuals. The anisocoria (the difference in pupillary size in the same individual) observed was not significantly different between the patient group and control individuals either in the basal state (before pharmacologic stimulation) or after pharmacologic stimulation. The mydriasis resulting from the instillation of the three sympathicomimetic drugs was symmetrical in both controls and patients both during and between the pain attacks. This finding is in clear contrast to what is found in cluster headache, in which there is a "Horner-like" syndrome on the symptomatic side. These two headaches thus seem to differ essentially with regard to this variable.

Adult↗

PubMed1987

Cluster headache pathogenesis: a pupillometric study.

Thirty-two cluster headache patients and healthy controls (n = 16-20 for the various tests) were examined by means of a Whitaker pupillometer during pain-free intervals. Eye drops of the sympathomimetic agents tyramine, hydroxyamphetamine, and phenylephrine were instilled into the conjunctival sacs on separate occasions, and pupillary diameters recorded at standard time intervals. The mydriatic responses of the two pupils were compared. A moderate, but statistically significant, basal relative miosis was found on the pain side in cluster headache. The symptomatic-side pupils were less responsive than their counterparts when stimulated with tyramine and hydroxyamphetamine, the difference being statistically significant for the OH-amphetamine test. With the phenylephrine test, however, the mydriasis on the symptomatic side significantly exceeded that of the contralateral pupil. This pattern of reactions does not quite correspond to those of "ordinary" Horner's syndrome (1st, 2nd, and 3rd neuron lesion). There are, however, gross similarities with the recently reported pattern in central sympathetic neuron dysfunction. In cluster headache there is probably a "Horner-like picture" rather than a proper Horner's syndrome.

Adult↗

PubMedDate not supplied

Electronic pupillometry in healthy controls. Response to sympathicomimetics.

The ocular sympathetic function was examined in 79 healthy volunteers (37 males and 42 females) by electronic pupillography. Pupillary diameters were first estimated under standard light conditions prior to drug application, these diameters being termed "basal values". Then, the pupils were stimulated pharmacologically by instillation of various sympathicomimetic drugs: tyramine tests were carried out in 42 individuals (24 females; 18 males), hydroxyamphetamine tests in 38 (22 females and 16 males), and phenylephrine tests in 43 individuals (23 females and 20 males). Generally, only a minor variation in the frequency of asymmetries was observed between sexes as well as between the various age groups, both when calculating the increase in pupillary diameter in millimeters, in per cent, and as the anisocoria index. In agreement with previous investigations, pupil size was found to diminish with age. The use of an age-matched control material is mandatory when comparing pupillographic recordings in patients in various categories, in the ordinary condition, as well as after topical drug administration.

Adolescent↗

PubMedDate not supplied

[Clinical and rheoencephalographical evaluation of prodectin in the treatment of cerebral arteriosclerosis].

The reported investigations were carried out in a group of patients with evidence of cerebral circulatory disturbances aged from 43 to 72 years treated with Prodectin for 5-7 weeks. The dynamics of the clinical manifestations and REG curves were analysed before and after treatment. REG investigations were done using a II type rheograph with Fc-M leads. The basic parameters of the REG waves and reaction to nitroglycerin were evaluated. The results of REG were compared with the results of similar investigations in an age-matched control group. In nearly half the patients a tendency was observed for REG tracing normalization wit clinical improvement. Most frequently shortening of the ascending part of the REG wave was observed.

Adult↗

PubMedDate not supplied

[Clinico-rheographical correlations in patients with cerebrovascular disorders treated with intravenous cinnarizine].

The aim of this study was to investigate the effects of parenteral administration of Cinnarazin on cerebral haemodynamics by means of rheoencephalography in patients with cerebrovascular diseases. The studied group included 32 patients aged from 39 to 78 years. Cinnarazin was given in doses of 25 to 50 mg (3-6) intravenously daily for 10 days. Rheoencephalographic investigations were carried out repeatedly (before intravenous Cinnarazin and during 30-60 minutes after injection of the preparation at intervals of 5-10 minutes). The investigations showed that: 1) intravenous Cinnarazin produced in patients with cerebrovascular diseases good effects, particularly in cases of transient circulatory disturbances in the brain, particularly in cases of atrial rhythm disorders, 2) particularly evident rheoencephalographic changes developed after from 10 to 20 minutes after Cinnarazin administration intravenously and were recorded during 2 hours, according to clinical data the effect of the treatment persisted during three months after completion of treatment.

Adult↗

PubMedDate not supplied

[Evaluation of the usefulness of rheoencephalography in diagnosing chronic cerebral circulatory failure].

Rheoencephalographic, electroencephalographic and echoencephalographic investigations were carried out in 44 patients with chronic cerebral circulatory failure aged from 49 to 79 years, and in a control group of 20 subjects in similar age range. The results of REG investigations suggested impaired elasticity and increased tonus of vascular walls in patients with cerebral circulatory failure. In comparison with EEG and EchoEG and REG investigation seems to be a more useful method for estimating the state of cerebral circulation.

Aged↗