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Biomedical subjects

M M Zahran

Publications and source records attributed to M M Zahran.

9 recordsLinked to original sources
PubMed1996

Synteny mapping in river buffalo.

The cosegregation of ten coding loci has been investigated, in a panel of 37 somatic cell hybrids resulting from the fusion of a hamster cell line and river buffalo lymphocytes, by use of Southern hybridization technique. Five syntenic groups, TCRB-PGY3, ASS-ABL, FUCA1P-CRYG, MBP-YES1, and CGN1-ACTA1, previously assigned to cattle as U13, U16, U17, U28, and U29 respectively, were also found to be syntenic in buffalo. Based on the extensive syntenic conservation and banding homology between cattle and river buffalo, comparative mapping predicts the localization of these syntenic groups on river buffalo Chromosomes (Chrs) :BBU7, BBU12, BBU2q, BBU22, and BBU4q respectively as they have been previously localized on cattle Chrs BTA4, BTA11, BTA2, BTA24 & BTA28.

Animals↗
PubMed1985

Immunochemical studies of serum, urine and calculus proteins in urolithiasis.

Total serum protein levels in 70 patients with urolithiasis were not significantly different from those in 20 control subjects, although certain variations were detected in individual protein patterns. In contrast, total urinary protein was significantly higher in patients with urolithiasis. 4-6 different components, i.e., albumin, alpha 1-acidic glycoprotein, alpha 1-antitrypsin, Gc-globulin, fibrinogen and immunoglobulin G, were found in the matrices of calculi and in urine, suggesting that proteinuria may play a role in the formation of stones in patients with urolithiasis.

Blood Proteins↗
PubMed1980

In situ hypothermic renal perfusion. Evaluation of three intracellular solutions.

Description of a simple technique for in situ hypothermic renal perfusion is presented. Three intracellular solutions simulating perfusates were tried on three groups of mongrel dogs with a fourth group that served as control. Right nephrectomy was performed on all dogs. The left kidney was perfused for two and one-half hours at a temperature of 15 degrees to 17 degrees C. Follow-up evaluation by estimation of five enzymes, glutamic oxaloacetic transaminase, alkaline phosphatase, lactic dehydrogenase, sorbitol dehydrogenase, and phospholexose isomerase in serum, urine, and renal tissue was conducted. Renal function was evaluated by the level of serum creatinine and its twenty-four-hour urinary excretion. Minimal biochemical changes comparable to the control group were observed in the group perfused by Chapman solution.

Alanine Transaminase↗
PubMed1980

Study of bilharzial uropathy by means of hippuran I131 extended renography.

Renal, ureteral, and vesicle functions were evaluated in 209 patients with obstructive lesions of the ureter due to schistosomiasis haematobia (bilharziasis), using Hippuran I131 extended renography. High values for Tmax. and T 1/2 were noted for both kidneys irrespective of radiological diagnosis of a left- or right-sided lesion. A high percentage of residual vesicle urine was demonstrated in a number of patients with bilharzial uro-obstructive lesions. The incidence of vesicoureteral reflux in relation to different lesions was also correlated. The results of this study support the concept that urinary schistosomiasis is a progressive disease which affects mainly the urinary bladder and lower ureter. The data obtained demonstrate the efficacy of extended renography in assessing renal, ureteral, and vesical function in patients with bilharziasis.

Adult↗
PubMed1979

Flap ureteroplasty for segmental structure of middle third of ureter.

A technique is described for repair of segmental stricture of the middle third of the ureter utilizing spiral or vertical flap from the proximal dilated ureter. In all cases a 10 F polyethylene ureteric stent with a ureterotomy exit 5 cm. distal to the repair site was used. Twenty-eight ureters in 27 patients were repaired by this technique, with good results in all except 3 cases which showed postoperative residual dilatation three months after surgery.

Adult↗
PubMed1976

Bilharziasis of urinary bladder and ureter: comparative histopathologic study.

The relative incidence and intensity of oviposition in schistosomiasis in different layers of both the urinary bladder and the ureter are presented. Histopathological changes in both organs are elucidated. Oviposition was heaviest in the submucosa of the urinary bladder, while the muscle layer was affected in 15% of specimens. Oviposition was mainly periureteral and in outer muscle layer of the ureter, and was present in only 22% in the ureteral submucosa. Epithelial changes, namely, Brunn nests, cystitis glandularis, cystitis cystica, and squamous metaplasia, were more marked in the bladder specimens than in the ureteral specimens. Squamous cell papilloma and squamous metaplasia associated with acanthosis of the bladder specimens were identified. Results indicate unanimously that the heavy deposition of ova in the submucosa of the bladder leads through its mechanical and toxic irritation to marked epithelial and premalignant changes which pave the way for the disturbing frequency of carcinoma of the bladder in the bilharzial patients which is not the case in the ureter.

Humans↗
PubMed1976

Effects of contraceptive pills and intrauterine devices on urinary bladder.

The incidence of bacteriuria and cystoscopic changes in women on oral contraceptives or users of IUD (intrauterine devices) were evaluated compared with a control group. Subjects with bacteriuria accounted for 40.5 per cent of pill users, 20 per cent of women fitted with IUD, and 16 per cent of the control group. Bladder trabeculations were found in 50.5 per cent of the pill group, 8.7 per cent of the IUD group, and 8 per cent of the controls. Congested bladder trigone was observed in 24.6 per cent of women fitted with an IUD. The mode of action of ovarian hormones and their possible side effects on the bladder are discussed. The relation of IUD to pelvic inflammatory disease and its effect on the urinary bladder are evaluated.

Adult↗