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Biomedical subjects

M Münzel

Publications and source records attributed to M Münzel.

At least 19 recordsLinked to original sources
PubMed1987

[Clinical and etiologic aspects of rupture of the membrane of the round window].

For more than 15 years, rupture of the round window membrane has been discussed as a possible cause of sudden sensineural hearing loss. With regard to the pathophysiological basis for such a rupture, an abnormality in the width of the aquaeductus cochlearis as well as anatomical variations of the round window membrane itself are presumed as causative factors. The authors report on six cases concerning this incidence. The indication for tympanoscopy and the technique for the closure of the round window fistula are reported. In 5 of the 6 patients treated in this manner, surgery the resulted in a significant and lasting hearing gain.

Adult↗
PubMed1986

[Laryngeal cancer and asbestosis].

The article deals with the connection between an exposure to asbestos and the development of a laryngeal carcinoma. In accordance with case reports and epidemiological studies from literature, the above mentioned causality can be presumed in certain cases. Although at present there is usually no legal compensation for a laryngeal carcinoma if someone has been exposed to asbestos, the reports from literature as mentioned above should be taken into consideration in every single case: In detail, this means that anamnestical facts of exposure to asbestos, pulmological status and the latency up to the development of the laryngeal carcinoma must be taken into consideration.

Asbestosis↗
PubMed1985

[Otologic manifestation of Wegener granulomatosis].

Ever since Wegener first described the granulomatosis named after him, involvement of the middle ear tracts as a consequence of inflammatory changes in the nose and the nasopharynx has been known. In recent years there have been a remarkable number of reports on a primary affection of the mucosa of the middle ear with Wegener's granulomatosis. The corresponding symptoms clearly precede the affection of the typical parts of predilection in the upper respiratory tract. A 37-year old woman patient is reported to have fallen ill with a primary left-sided serous otitis media. Only several months later the changes typical of Wegener's granulomatosis concerning the nasal mucosa, trachea and especially the kidneys set in. The differential diagnostic difficulties appear with respect to the classification of inflammatory granulomatosis of the mucosa of the middle ear. The now valid concept of chemotherapy regarding treatment with cyclophosphamide and corticosteroids. Premature therapy can achieve encouragingly long remission of a relatively high number of cases of this disease.

Adult↗
PubMed1980

[Occult sinusitis in childhood (author's transl)].

Occult sinusitis in childhood is a special form of chronic rhinosinusitis. The symptoms of chronic sinusitis are not clear in these patients, but the diagnosis can be confirmed both radiologically and endoscopically. Aetiologically, an immunoincompetence or mucoviscidosis should be remembered. As well as conservative measures, treatment by antral lavage or antrostomy is recommended.

Child↗
PubMed1978

[Neurogenic tumor of the larynx (author's transl)].

The authors report a case of a 13-year old girl with a neurogenic tumor of the larynx. The tumor was localized in the submucosal region of the arytenoid and aryepiglottic area on the left side of the larynx. Histologically, it was classified as a neurinoma. As it was impossible to remove the tumor totally by endoscopic way, a lateral hypopharyngotomy had to be performed. Two years after this procedure, there are no functional defects or signs of recurrency.

Adolescent↗
PubMed1977

[On the ligation of Stenon's duct in chronic-recurrent parotitis (author's transl)].

Ligation of Stenon's duct represents a possibility for treatment of chronic-recurrent parotitis. This procedure leads to an atrophy of the gland parenchyma. In one case, observed by us as a complication of this method ligation of the duct was followed by the formation of a great parotid gland cyst. Under respect of this casuistic report, possibilities are discussed to prevent similar and other complications. They consist in the section of the preganglionic fibers of the tympanic plexus respectively in a simultaneous radiation therapy of the diseased gland.

Aged↗
PubMed1977

[Endoscopic surgery in bilateral vocal cord paralysis (author's transl)].

The surgical treatments of bilateral vocal cord paralysis are briefly described, and the various endoscopic excisions of the arytenoid are presented. For this latter surgery careful preoperative assessment is necessary. Problems related to the optimal time for surgery and to the surgical technique itself are discussed.

Dilatation↗
PubMed1976

The diagnostic value of intranasal tests in allergic rhinopathy.

The method of the intranasal test, used by us, is described. It consists in a direct application of the allergen, which is presumed after a pilot-skin-test. The resulting reaction is documented by rhinomanometry. The special technical aspects of the test and the sources of error are emphasized.

Humans↗
PubMed1976

[The proteincomposition of human parotid saliva in acute and chronic parotitis. Quantitativ densitometry of single protein-fractions in comparison to normal secretions].

By means of acrylamidgelectrophoresis parotid secretions of patients with acute and chronic parotitis were examined. Thereby significant changes in protein patterns of electrophoretic separation were found. Especially two bands are described in detail. One in the cathodal near gel region, the isoamylases, and the otherone in the anodal part of the gel, identified as albumin. In rest and under stimulation these bands show signficant changes compared to normal secretions. Furthermore information about the capacity of the parotid gland parenchyma is won by observing the changes of amylase bands in rest and under stimulation in chronic parotitis without actute exacerbations. The amylase shows a remarked decreased secretion in chronic parotitis under stimulation corresponding to parenchymalteration. The same happens with the albuminexcretion as parameter for ductlesions. In chronic parotitis albmuninexcretion goes parallel to duct changes in sialography. Therefore by discelectrophoretic separation of native parotid saliva a helpful mean for diagnostic use is given, besides sialography and scintigraphy.

Acute Disease↗
PubMed1976

[Subepithelial changes in simple leukoplakic hyperplasia of the laryngeal mucosa (author's transl)].

Subepithelial changes in hyperplasia of the laryngeal mucosa consist in edema and cellular inflammatory reaction. 150 cases of epithelial hyperplasia without atypia have been investigated histologically in regard to these subepithelial changes. The cases were subdivided into 3 categories, according to the degree of hyperplasia. The degree of inflammatory reaction in the subepithelial compartment also was classfied into 3 groups. A, B and C. There was evidence of a positive correlation between the increase in the epithelial hyperplasia and the increase of a positive correlation between the increase in the inflammatory process in the subepithelial layer. It could not be decided, which one of these two pathological changes was primary and which secondary. The therapy, however, should aim at both, epithelial proliferation, as well as, subepithelial inflammation.

Epithelial Cells↗
PubMed1976

[Biochemical aspects of human salivary gland secretions].

Salivary secretions fulfill some specific functions within the human organism, which are explained. The scientific research concerning these fluids dealt during the last years especially with the formation of these secretions within the glands. These investigations have been performed mostly in animal experiments. The results obtained are briefly summarized. For investigations in human salivary secretions, it was necessary to develop some new techniques for collecting the secretions from separate glands. The interpretation of sialo-chemical facts is often difficult as there are many factors, influencing the flow-rate and the composition of the fluids. These factors, as known up to now, are explained. In separate chapters, the inorganic and organic composition of human salivary secretions is described. Concerning the protein-composition of human saliva, there are some newer results as aspects, which are discussed. It must be the aim of a chemical analysis to discover the interrelation between the differences in salivary secretions and pathological conditions. Therefore changes of the salivary secretions in systemic diseases are reported as well as changes in the compositions of these fluids in pathological conditions of the glands themselves. According to the results from own experiments and from the literature, it should be possible in the future, to develop some new diagnostic methods by analysing the salivary secretions.

Humans↗
PubMed1975

[Simultaneous estimation of flow rates, electrolyte and proteinconcentration and discelectrophoretic separation of fractionated human parotid saliva(author's transl)].

Fractionated human parotid saliva from normal persons was separated by column-acryamid-gel discelectrophoresis. Flow rates, electrolyte-concentrations and total protein content of the stimulated and unstimulated parotid-secretion were determined simultaneously. Significant patterns of proteincomposition were found for stimulated and unstimulated parotid saliva. Most typical changes of protein bands were found in the anodal near gel region, within a group of four bands, called by us f, g, h and i. In the cathodal near gel region as well significant changes in the bands a, b, c and d were found; by glycoprotein staining these bands showed good staining.

Adolescent↗
PubMed1975

[Exploration of parotid saliva proteins by means of one-and-two-dimensional immunelectrophoresis, immunodiffusion and discelectrophoresis (author's transl)].

The protein composition of human parotid saliva was explored by means of one- and two-dimensional immunelectrophoresis as well as by a modified Ouchterolony-technique and discelectrophoresis, where usually at least 14 components of parotid-saliva-proteins can be differentiated. According to the results of immunelectrophoresis and discelectrophoresis, the kind and number of protein components are interindividually constant, yet, there are great interindividual differences concerning the concentration of the single components.

Adolescent↗
PubMed1975

[Tuberculosis of the middle ear and tympanoplasty (author's transl)].

The clinical picture of tuberculous otitis media is described. Nowadays the desease usually appears as a infection of the mucous membrane. The problems concerning the diagnosis of this specific infection by histological or bacteriological methods are discussed. Special questions about the performance of a tympanoplasty in a tuberculous otitis media are considered.

Adult↗
PubMed1975

[Simultaneous determination of lysozyme and IgA-content in human parotid saliva, compared with flow-rate and totalprotein-secretion during rest and stimulation (author's transl)].

Parotid saliva was collected in 10-minutes-fractions during rest and stimulation from 66 healthy individuals. The time of collection was 80 minutes, in every sample flow-rate, total-protein-concentration, IgA- and Lysozyme-content were determined. According to sex and age of the individuals, the results obtained were classified in four groups. Stimulation produced characteristic changes in the flow-rates, which seemed to be correlated with the age of the persons. The total-protein-concentration of the single samples showed great differences; yet, regarding flow-rate and proteinconcentration together, the so calculated secretion of protein of every gland was almost the same. Secretion of IgA was dependent on age and sex: the secretion-rate was greater in females than in males. Besides, younger people had lower IgA-concentrations than older ones. On the other hand, lysozyme-secretion was reciprocal to IgA-secretion. The concentration of lysozyme was much higher in young persons compared with the older group. The clinical importance of this findings is discussed.

Adolescent↗
PubMed1975

[The immunglobulin-content of human parotid saliva (author's transl)].

By means of radial immundiffusion, the content of IgA, IgG, IgM and IgE in 22 healthy persons was measured. The parotid saliva has been collected under standardized stimulation-conditions in 10 minutes-fractions during a time of 30 minutes. While IgM and IgE could not be found with this method, IgA and IgG were present in a concentration easy to be measured. For the two immunglobulins, a different and characteristical change in their concentration was found during stimulation. This difference can be explained by the different origin of the substances.

Adult↗
PubMed1975

[On the absorption of decongestive nose-drops-investigation with a radioactive labelled imidazoline-derivate (author's transl)].

In animal experiments, the absorption of a nasal decongestive substance after application to the nasal mucosa was studied. After an exposition-time of 60 minutes, about 1% of the substance applied could be measured in the total blood volume. An incorporation of the substance into proteins of the nasal mucosa could not be found. By means of frozen-section-autoradiography, the way of the applied decongestive substance through the mucosa could be investigated. The reasons for the relative small absorption rate are discussed. The chemical structure and the vasoconstrictory effect probably are reliable for that.

1-Naphthylamine↗