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M MANN

Publications and source records attributed to M MANN.

At least 37 records · Page 2Linked to original sources
PubMed1957

The adrenaline and noradrenaline content of the adrenal gland of the cat following depletion by acetylcholine.

This paper describes the attempts that were made to obtain a replacement of adrenaline and noradrenaline in the adrenal gland of the atropinized cat, subsequent to the depletion of the gland by repeated intravenous doses of acetylcholine. In the anaesthetized animal, there was no replacement of adrenal amines within 15 hours of the depletion. The further loss of amine that occurred during this time was prevented by the de nervation of the gland. If the animal was allowed to recover from the anaesthetic there was some replacement of amines within 2 to 3 days, provided that the condition of the animal was satisfactory. By 6 to 7 days the total amine content had returned to its initial level, but there was now an alteration in the relative proportions of the two amines. Although the adrenaline was still well below the resting level, the noradrenaline was several times its initial value. By one month, the noradrenaline had decreased and the adrenaline had increased to their initial amounts and proportions. Thus this work gives evidence for the formation of adrenaline from noradrenaline.

Acetylcholine↗
PubMed1957

The release of adrenaline and noradrenaline from the adrenal gland of the cat by acetylcholine.

The adrenal glands of atropinized cats were depleted of their content of adrenaline and noradrenaline by repeated intravenous doses of acetylcholine. In each experiment there was a similar percentage loss of both amines. This was irrespective of the degree of depletion, which ranged from 7.1% to 86.5%. In some experiments, adrenal blood was collected and it was found that the percentage of noradrenaline in the adrenal venous effluent (mean 62.0%) was similar to that in the amine lost from the depleted gland (mean 63.7%). In some experiments, the adrenaline and noradrenaline lost from the gland could be recovered quantitatively in the adrenal blood. The results indicate that, under these experimental conditions, synthesis is not taking place concurrently with the liberation of amines or that it is taking place so slowly as not to be detected.

Acetylcholine↗