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Biomedical subjects

M MacDonnell

Publications and source records attributed to M MacDonnell.

3 recordsLinked to original sources

Perceptions of physical fitness and exercise activity among older adults.

The purpose of this research was to examine older adults' perceptions of physical fitness and exercise. This qualitative study was divided into four stages as described by Berg (1989): identification of the concept of the study; development of the interview guide; collection of data; and data analysis. Twenty-three older adults, aged 63-82 years (9 females, 14 males), participated in the interviews. Transcripts were analysed using content analysis. Three major themes emerged as the participants viewed physical fitness in terms of: functional independence ('being able to do'); holism ('mind-body works together'); and age reference (-for people my age'). Nine elements which impeded or enhanced physical activity were identified. Implications for education, research and practice are discussed.

Aged↗

Differential response of normal and tumour oesophageal explant cultures to radiation.

An in vitro method is described which allows radiation dose response data to be obtained for samples of oesophageal mucosa obtained from patients undergoing resection for adeno or squamous cell carcinoma. Data are obtained using a growth endpoint from explant cultures and may be expressed in terms of absolute growth inhibition or reduced rate of growth. Radiation dose response curves suggest that cell survival is in the range expected for mammalian cells but that, as is found clinically, tumour cells are far more resistant to radiation than normal cells. The technique provides a means of assessing differential radiation response in normal and tumour tissues from the same patient, as it is unusual for both to be amenable to clonogenic assay.

Adenocarcinoma↗