Biomedical subjects

M Macanović

Publications and source records attributed to M Macanović.

13 recordsLinked to original sources

PubMed1991

[Anticardiolipin antibodies--detection and diagnostic value].

Anticardiolipin antibodies belong to a family of antibodies to phospholid and are important in pathogenesis of some diseases. Statistically significant high titer of circulating anticardiolipin antibodies were found in SLE patients, thromboembolic events, thrombocytopenia and recurrent fetal loss. We tested 53 sera of SLE patients to anticardiolipin antibodies by own modification of ELISA. Only two sera were positive, one of them was associated with recurrent fetal loss and disease. The incidence of anticardiolipin antibodies in we have found no correlation with the activity of to those reported in other studies. Our tested sera (4%) was much lower in comparison.

Antibodies, Anticardiolipin↗

PubMed1991

[The complement activation system in acute poststreptococcal glomerulonephritis].

The activation of the complement system is very important part of the immunologic process. Measuring levels of products of complement activation is a useful diagnostic and prognostic procedure. This report presents the results of a follow-up of 54 children with acute poststreptococcal glomerulonephritis. At the beginning of the disease, all patients (i. e. 100%) had decreased levels of C3 component of the complement system, and 72.2% patients had decreased levels of the haemolytic complement. The mean value of the control measurements increased significantly from one measurement to another (with p < 0.01, and within 6 weeks after the beginning of the disease, it reached the normal range. According to our results, the activation of the complement system was induced by the classical pathway. We cannot explain why the component C4 did not take part in it. According to the results of the haemolytic assay, the alternative pathway of activation was used too. We found that there was a correlation between improvement of clinical features and decrease of metabolisation of complement components.

Acute Disease↗

PubMed1991

[Antithrombin III in chronic renal insufficiency].

In a group of fourty eight patients with chronic renal failure and a group of twenty patients on chronic hemodialysis, we studied the biologic activity of Antithrombin III by using immunoelectrophoresis and coagulation methods. We found that increased values of biologic activity of Antithrombin III, were significant. This can be an additional factor in explaining the origin of bleeding in patients with chronic renal failure and uremia without nephrotic syndrome. The index of biologic activity of Antithrombin III was significantly decreased after giving heparin to the patients with chronic renal failure on hemodialysis. The obtained values were low and within the ranges found in patients suffering from thrombosis. This decrease in biologic activity of Antithrombin III, together with the well known increase in factors of hemostasis during hemodialysis, is an important cause of frequent thrombosis, which can be fatal for patients. In the same group, antigenic values of Antithrombin III measured before and after giving heparin, were not changed. These facts show the necessity of measuring the biologic activity of Antithrombin III because the quantity of Antithrombin III is not a reliable indicator of its functional validity.

Antithrombin III↗

PubMed1986