PubMed Health⌕ Search

Biomedical subjects

M Macchini

Publications and source records attributed to M Macchini.

At least 19 recordsLinked to original sources

[Stereotaxic breast microhistology].

Mammography is currently the most reliable imaging technique to detect clinically occult breast cancer. Stereotaxic-guided aspiration biopsy during mammography allows lesion nature to be diagnosed in many cases. Our experience with 72 microhistologic breast samplings with fine-needle aspiration cytology is reported; 50% of inadequate cytologic samplings were avoided. Adequate cytologic samples were obtained in 88.9% of cases, while microhistologic samples were adequate in 94.4% of cases. Inadequate samples were 11.1% and 5.6%, respectively. Microhistologic biopsies yielded fewer questionable results than fine-needle aspiration cytology, which helped reduce the number of unnecessary biopsies. This method, which is reliable and well tolerated by the patients, can be considered as a valuable alternative procedure to fine-needle aspiration cytology.

Adult↗

[The pulsed Doppler echo of the internal mammary artery].

In this study the authors discuss the results obtained using pulsed Doppler to evaluate internal mammary artery blood flow velocity in normal, dysplastic and neoplastic breasts. The following parameters were evaluated: percentage of artery localization, vessel diameter, and blood flow velocity. One hundred and seventy-five patients were examined by pulsed Doppler US and mammography in the same sitting. US evaluation of the internal mammary artery was possible in 156 cases. These patients were divided into 3 groups according to Wolfe's classification: normal (38 patients), dysplastic (74 patients) and neoplastic (44 patients). The mean blood flow velocity was estimated in each group; a significant difference was observed between normal (11.8 +/- 6 cm/s) and dysplastic (22.5 +/- 11 cm/s) patients. As for neoplastic patients, similar values were observed in benign (20.6 +/- 9 cm/s) and malignant (25.8 +/- 11 cm/s) lesions. Benign and malignant lesions were distinguished also according to Wolfe's parameters. In the patients with malignant lesions and normal breasts there was an increase in blood flow velocity--which was not observed in dysplastic breasts. In benign lesions in normal or dysplastic breasts, the blood flow velocity was similar to that observed in the respective group of nonpathologic breasts.

Adult↗

[Multi-institution, multidisciplinary radiology and endoscopy trial of the diagnostic accuracy of the double contrast examination of the stomach surface].

In 12 X-ray and gastroenterology departments 1570 patients, clinically suspected to have a gastric pathology, have been examined by double contrast (surface) examination of the stomach followed by gastroscopy. Diagnostic accuracy was 93% in respect of endoscopic data, assumed correct by hypothesis. On the basis of a cost and benefit evaluation, made according to the well known criteria, a wider routine use of the double contrast technique is proposed.

Adolescent↗

Effects of streptozotocin in the WDHA syndrome not amenable to radical surgery.

Two cases of Verner-Morrison syndrome due to pancreatic carcinoma were treated H. h streptozotocin (STZ) according to the schedule suggested by the Division of Cancer Treatment of the National Cancer Institute. In both patients the drug caused a remission of the WDHA syndrome: therefore, this finding seems to recommend such treatment when the syndrome is not amenable to radical surgery. Renal toxicity is, however, an important limitation. It occurs mostly when STZ is administered by iv infusion. In one of the patients, after a serious impairment of renal function caused by STZ, prednisone controlled the syndrome for a long period of time.

Female↗