Biomedical subjects

M Machálka

Publications and source records attributed to M Machálka.

11 recordsLinked to original sources

PubMed2006

[Osteonecrosis of the jaw in the course of multiple myeloma treatment and bisphosphonate administration].

The osteonecrosis of jaws is a phenomena newly described in the connection with bisphosphonate therapy. We describe a case of a 41 years old man with multiple myeloma, who developed the osteonecrosis of jaw in the course of antimyeloma therapy. The men had tooth pain from the beginning of the chemotherapy, but the extraction was performed till one month before high dose chemotherapy with peripheral stem cell transplantations, when the conservative therapy was find unsatisfactory. Bisphosphonate were administered from the beginning of the chemotherapy, the bisphosphonate therapy was started with clodronate and later changed to zoledronate. One year from the tooth extraction the wound did not heeled and therefore resection of the necrotic bone was performed. The pain in the jaw was diminished, but the wound is not completely heeled. The administration of bisphosphonate was stopped after the diagnosis osteonecrosis of the jaws.

Adult↗

PubMed2003

Epithelioid hemangioendothelioma of the mandible.

The authors describe a locally recurrent tumor of the mandible whose microscopic structure and immunohistochemical findings corresponded to an epithelioid hemangioendothelioma. The tumorous cells had an epithelioid character, they created rudimentary vascular lumina, and they focally expressed vascular markers CD 34, CD 31, and F VIII. Locally the tumor grew aggressively. During the last recurrence, the tumor even affected the already healed and rebuilt bone graft, which was incorporated after the primary resection of the mandibular body. From the histological point of view, the tumor approximated an angiosarcoma. No metastases occurred.

Aged↗

PubMed2000

Arteriovenous malformations of the orofacial area.

Vascular lesions are pathological residues of the embryonic vascular system and can be divided into two main groups. The first group comprises haemangiomas, which are typical of childhood and involute spontaneously. The second group is formed by lesions without active proliferation, which include, among others, arteriovenous malformations that are congenital and grow proportionately with the subject. The authors present two cases of arteriovenous malformations of the orofacial area and discuss possibilities for modern diagnosis and treatment. Precise diagnosis and effective treatment of vascular lesions should be ensured by a diagnostic and therapeutic team of specialists from several disciplines (maxillofacial, ENT, plastic and general surgeon, paediatrician, haematologist, anaesthesiologist and possibly a neurosurgeon), headed by an intervention radiologist.

Arteriovenous Malformations↗

PubMed1983