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Biomedical subjects

M Machalski

Publications and source records attributed to M Machalski.

15 recordsLinked to original sources
PubMed1992

Anti-elastin antibodies in patients with lung cancer.

The aim of this study was to investigate anti-elastin antibodies of the IgG and IgM types in sera of patients suffering from lung cancer, using the DOT immunobinding assay. We studied 96 pathological and 40 control sera. Anti-elastin antibodies were found to be present in 45% of patients with small cell lung cancer, 19% of subjects with adenocarcinoma and not-identified lung tumor and 15% of patients with squamous cell lung cancer. They circulated in 5% of control persons only. The highest values of their titers were observed in the advanced stages of disease. In 55% of anti-elastin antibody positive small cell lung cancer patients, antibodies were of the IgM type, suggesting the initial step of the autoimmunization to elastin.

Adenocarcinoma↗
PubMed1990

A new chemotherapeutic regimen in the treatment of advanced gastric cancer.

The results of different chemotherapeutic regimens used in the treatment of advanced gastric cancer are compared. Three groups of patients were evaluated. The first group (59 patients) was treated by a new regimen consisting of methotrexate, 5-fluorouracil, cyclophosphamide and lederfolin (MFC + CF), the second group (21 patients) was treated by COnFU regimen (cyclophosphamide, vincristine, 5-fluorouracil), and the third group (35 patients) was treated with 5-fluorouracil (5-FU) alone. The control group of 41 patients with advanced gastric cancer was not treated cytostatically. The percentages of positive responses were as follows: 49.2% in the group treated with the new regimen, 33.3% in the COnFU group, and 14.3% in the 5-fluorouracil group. Median survival time of patients treated with the new regimen was significantly longer than that in the control group. Toxicity resulting from the new regimen treatment was moderate. The results of the new regimen can be compared to those obtained by other authors using the FAM regimen.

Adult↗
PubMed1989

[Multiple primary neoplasms].

In the years 1980-1987 in the Department of Internal Diseases, Silesian Medical Academy in Katowice 32 patients were observed with multiple malignant neoplasms of various organs. The time from the diagnosis of the first neoplasm to the appearance of the second one was from 0 to 168 months (mean 61.8 months). The second neoplasm developed in over half the cases (53.1%) after more than 5 years from the first one. The most frequent first neoplasms were: Hodgkin's disease and breast carcinoma, and the most frequent second neoplasm was colonic carcinoma, gastric carcinoma and endometrial carcinoma. The necessity of prolonged observation of patients with malignant neoplasms during many years is stressed.

Adolescent↗
PubMed1989

[Transcutaneous stimulation of the heart ventricles: its effectiveness, comfort during the examination and new diagnostic possibility].

An attempt of assessment of transcutaneous cardiac pacing tolerance in healthy volunteers was carried out as well as abilities of this method utilization for examination of retrograde atrioventricular conduction. Ventricles were paced through highohm electrodes positioned on the chest wall with simultaneous recordings of transoesophageal ecg at the level of the left atrium and the sphygmogram of the right common corotid artery. Pacing perception threshold, skeletal muscle stimulation threshold, cardiac pacing threshold, algesic and myo-respiratory threshold of examination tolerance were estimated. Effective ventricular pacing within the range of stimulation tolerance was obtained in 10 of 15 patients (67%). Mean ventricular pacing threshold was higher than pacing perception and skeletal muscles stimulation thresholds (42 mA; 9.4 mA and 20.2 mA). Ventricular pacing threshold was lower than algesic and muscles thresholds of examination tolerance (60-70 mA) warranting relatively good tolerance of transcutaneous cardiac ventricular pacing. In 8 of 10 persons with effective ventricular stimulation retrograde a-v nodal conduction was stated which proved that transcutaneous cardiac ventricular stimulation can be used for noninvasive assessment of retrograde a-v nodal conduction.

Adult↗
PubMedDate not supplied

[Evaluation of ambulatory treatment of advanced forms of Hodgkin's disease with special reference to psychological, social and economic aspects].

Patients with advanced lymphogranulomatosis were divided into two subgroups. One, including 9 patients was treated in the hospital, and the second, including 21 patients, was treated at out-patient department. Results of the treatment and its adverse reactions were not significantly different in patients treated on out-patient basis and in hospital. However, unfavourable effect of therapy on patient's psychological status (anxiety) was less expressed in out-patient conditions. Such a way of treatment enables also considerable savings related to the repeated hospitalizations.

Adolescent↗
PubMedDate not supplied

Immunoglobulins and complement components levels in patients with lung cancer.

Sera from 96 patients with lung cancer were assayed in order to evaluate the concentrations of IgG, IgA, IgM, C3c and C4. Histologically, 49 of the patients had squamous cell carcinoma, 11--adenocarcinoma, 20--small cell carcinoma and 16--not identified lung cancer. No statistically significant differences were found between the concentrations of IgG and IgM in patients with carcinoma of the lung versus subjects in the control group. Both serum IgA and complement components (C30 and C4) were significantly elevated in almost all patients from the tumor group as compared with the levels in the control group.

Adenocarcinoma↗
PubMedDate not supplied

[Anti-elastin antibodies in systemic lupus erythematosus].

Immunological response to elastin-derived peptides may cause tissue damage with subsequent degradation of the elastic fibres. Therefore, an incidence of anti-elastin antibodies in sera of patients with the systemic lupus erythematosus was studied. Sixty sera from 50 patients with systemic lupus erythematosus and 50 healthy subjects were assayed with dot-immunobinding technique. Titre 1:10 was considered diagnostically significant. Anti-elastin antibodies were diagnosed in 19 patients (31%) where as they were absent in the control group. In all cases anti-elastin antibodies were IgG.

Adult↗
PubMedDate not supplied

[Results of combined therapy in patients with nonseminomatous testicular tumors].

The results of multidrug therapy of 44 male patients with non-seminomatous testicular tumours are discussed. The diagnosed tumours were of all stages of the clinical advances and were treated with combined chemotherapy (surgery and PVP regimen). Thirty two patients (73%) are followed up between 7 and 103 months and survived, complete remission is noted in 29 patients (66%) including 6 patients who survived over 5 years. Symptoms of the tumour are found in 3 patients. Twelve patients (27%) died. The treatment did not produce life-threatening complications. The obtained results have been compared with those reported by other authors.

Adolescent↗
PubMedDate not supplied

[Prevention of systemic lupus erythematosus in children born to mothers treated for this disease].

Genetic predisposition and environmental factors (physical, chemical, hormonal and drugs inducing collagen-like syndrome) play an important role in the pathogenesis of the systemic lupus erythematosus. Elimination of these factors from the environment of the genetically predisposed individuals may prevent part of them against the disease. Basing on the above assumption, a chart of prophylaxis has been constructed and distributed among the mothers with the systemic lupus erythematosus, recommending prophylactic measures in both mothers and children. Within 1977-1987, 50 children were examined from time to time. Basic laboratory tests, phenomenon LE, antinuclear antibodies and antibodies anti-DNA have been determined. Transient presence of antinuclear antibodies was seen in 23 children. A tendency to an increase in the antibody titre was observed in girls of this group whereas a decrease in the titre was noted in the boys with the time lapse. Systemic lupus erythematosus prophylaxis in both mothers and children is uncomplicated and favourable for children. Regular determination of antibodies enables early diagnosis of the disease.

Adolescent↗