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Biomedical subjects

M Maddox

Publications and source records attributed to M Maddox.

13 recordsLinked to original sources
PubMed2001

Familial gonadotropin-releasing hormone resistance and hypogonadotropic hypogonadism in a family with multiple affected individuals.

OBJECTIVE: To characterize the phenotype of idiopathic hypogonadotropic hypogonadism due to compound heterozygous GnRHR gene mutations (Arg262Gln/Tyr284Cys). DESIGN: Retrospective review. SETTING: Tertiary medical center. PATIENT(S): Family containing four siblings (three female and one male) with complete idiopathic hypogonadotropic hypogonadism. INTERVENTION(S): Baseline and stimulated laboratory studies. One patient received GnRH treatment and one received human menopausal gonadotropins. MAIN OUTCOME MEASURE(S): Clinical phenotype vs. genotype is assessed by endocrine studies, karyotype, pedigree, and review of pathology slides of ovarian neoplasm. RESULT(S): With GnRH stimulation, two patients with idiopathic hypogonadotropic hypogonadism had maximum LH < 10 mIU/mL, and two others had peak LH > 10 mIU/mL. With repeated GnRH stimulation 24 hours later, gonadotropin levels in all patients were increased. Stimulation of thyroid-releasing hormone and tests for insulin-induced hypoglycemia were normal. One affected patient did not ovulate after GnRH treatment, but her sister ovulated with gonadotropin treatment. Another affected sibling had bilateral oophorectomy for seromucinous cystadenomas, and her hypogonadotropic state remained after castration. The man with idiopathic hypogonadotropic hypogonadism and his unaffected brother had a ring chromosome 21. CONCLUSION(S): All patients with complete idiopathic hypogonadotropic hypogonadism had the same GnRHR mutations, but clinical presentations and endocrinologic responses were heterogeneous. Gonadotropin levels remained low in patients with idiopathic hypogonadotropic hypogonadism after castration, and ring chromosome 21 was present, suggesting that sequences from this chromosome could affect the idiopathic hypogonadotropic hypogonadism phenotype.

Adult↗
PubMed2001

Psychosocial recovery following ICU: experiences and influences upon discharge to the community.

While appropriate referrals to community services upon discharge home may address the physical needs of former intensive care patients, the psychological needs may be overlooked. This pilot study describes the recovery period following discharge to home of former intensive care unit (ICU) patients and their significant others, and identifies factors influencing recovery and the role of community support in the recovery period.Semi-structured interviews were conducted with five patients and four significant others, 6 to 15 weeks following discharge from the ICU. Data were analysed using constant comparison to identify recurring categories and themes. The recovery period was characterized by the patients' focus on physical recovery with the major theme described as 'moving on', incorporating normalizing life, return to usual routines, and leaving behind the ICU experience. Factors influencing the recovery period included individual attitudes, prior experiences, the ICU experience and support of family and friends. Community support was not commonly utilized with participants describing a perceived stigma attached to asking for professional help. Attention to physical needs and care often masked the psychological support received, particularly from family members. Despite awareness of community supports, patients were generally reluctant to avail themselves of any of these services.

Adaptation, Psychological↗
PubMed2001

A gift of song.

Explore the source record for details and available documents.

Christianity↗
PubMed2001

Teaching spirituality to nurse practitioner students: the importance of the interconnection of mind, body, and spirit.

PURPOSE: To describe the author's experience in locating and implementing a spiritual assessment tool in teaching a first semester clinical nurse practitioner (NP) course. DATA SOURCES: Selected articles and responses of NP students to the use of the tool. CONCLUSIONS: A spiritual assessment is an important component of a comprehensive health assessment. The use of a formal structured protocol provides a framework for beginning students to become comfortable with sprirituality and spiritual assessments and to begin to recognize spiritual distress in clients. IMPLICATIONS FOR PRACTICE: The protocol used in the course is very extensive and might not be practical in a busy practice setting. An alternative, 4-point assessment is provided.

Curriculum↗
PubMed1999

Older women and the meaning of health.

Health promotion has become an essential component of comprehensive health care, especially considering the growing female population. Older women, in particular, have demonstrated an increasing need for preventive services or health care maintenance and promotion. These needs consist of services provided by health care professionals that can help women meet their own self-care demands. However, before the health care needs of women can be met, they first must be identified. Using Orem's Self-Care Theory, a three-part qualitative phenomenological study was conducted in an attempt to understand what health actually means to older women and what types of health behaviors they feel are important to maintain or promote health. Three different groups of women age 55 and older with a variety of education, socioeconomic, and racial backgrounds were interviewed. Their responses were analyzed carefully, and each participant was interviewed a second time to validate recurrent themes regarding their statements about health. Results of the interviews with the three different groups of women were surprisingly similar. Although each participant had a unique application of their definition of health, there were five recurrent themes identified by 75% to 80% of the women. The themes were interactions with a being greater than themselves, acceptance of self, humor, flexibility, and being other-centered. Numerous examples supported the five themes. In addition, several "healthy behaviors" also were identified. Based on the findings of this 3-year study, older women seem to have their own perspectives on what health actually means and how they can best monitor or maintain their health. While the list is slightly different than the traditional one prescribed by health care professionals, perhaps it is time to encourage older adults to become more of a partner in their care. These healthy behaviors could be incorporated easily into the treatment and management plans and thereby reflect both parties' definitions of what it means to be healthy. Health care professionals must continue to ask older adults about their view of health and encourage their partnership in health-related issues. All individuals, no matter what age, are being encouraged to assume more responsibility for their own personal health, and by including older adults in the decision-making process, this partnership can be strengthened.

Aged↗
PubMed1994

Multicomponent intervention for agitated behavior in a person with Alzheimer's disease.

We evaluated a multicomponent intervention for agitated behavior in a man with probable Alzheimer's disease. Hypotheses about variables controlling his agitated behavior guided intervention design. Based on staff interviews, direct observations, and brief experimental probes, intervention components were chosen to increase rate of reinforcement and decrease aversive aspects of his job. Intervention reduced agitated behavior without disrupting his work rate.

Aged↗
PubMed1983

Implementing EPSDT screening in the public school: resolving some issues.

The use of the Early and Periodic Screening, Diagnosis and Treatment Program (EPSDT) as an adjunct to school health and education services was investigated. In the process of developing systematic procedures for public schools to use in collaborating with EPSDT, critical procedural, cost and policy issues surfaced. Methods for determining and protecting student eligibility information, estimating the cost and feasibility of the procedures and the role of local and state school health policy are examined. Specific recommendations are made. Information is provided that will help others interested in involving the public schools in the EPSDT program.

Child↗