Biomedical subjects
Publications and source records attributed to M Mafee.
The value of CT in the easy diagnosis of lipomas and associated anomalies of the corpus callosum, thus avoiding angiography and pneumoencephalography, is reported in five cases. An angiogram was performed in only one of the five cases and provided no additional diagnostic information.
Occipital lobe atrophy can be identified on CT. In a review of 90 selected cases with brain ischemia symptoms, 45 cases were found to have hindbrain ischemia with symptoms of vertigo and/or 'blurred vision.' Ten cases (22%) had normal CT studies and 35 cases (78%) had abnormal CT studies. The CT brain scan of the cerebellum and occipital lobes has a place in determining whether a patient with clinical hindbrain ischemia is a candidate for angiography and vertebral artery bypass surgery.
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The reliability of central vestibular signs such as decruitment in signifying retrolabyrinthine lesions has been well established. This study was initiated to determine if this and other central vestibular signs, individually or collectively, indicate involvement of specific anatomic structures in the posterior fossa. Forty-six patients with morphologic lesions defined by computerized tomography (CT), pneumo-CT autopsy were studied. Oculomotor signs showed a statistically significant correlation with lesions of the archicerebellum. The other central vestibular signs did not show any correlation.
The term craniovertebral junction refers to an area comprising the inferior portion of the occipital bone surrounding the foramen magnum and the first two cervical vertebrae. A variety of anomalies of bony, meningeal, and neural elements are known to occur in this region, producing a wide spectrum of clinical symptoms. These can range from dizziness, ataxia, and nuchal headaches to obvious quadriparesis and cranial nerve palsies. Often the symptoms are vague with an evolution marked by temporary exacerbations and remissions. The diagnosis can be difficult, and in our experience is best achieved by combining a neurotologic and neurologic evaluation. We discuss here the symptoms and diagnosis in ten patients with lesions at the craniovertebral junction. The surgical management of two cases of basilar invagination is described, and the controversies regarding the technique are discussed.
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