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Biomedical subjects

M Magnano

Publications and source records attributed to M Magnano.

41 records · Page 3Linked to original sources
PubMedDate not supplied

[Nasosinus tumors: the problem of orbital invasion].

Neoplasms of the nasal cavity and paranasal sinuses constitute less than 1% of all malignant tumors and account for 3% of those within the E.N.T. field. The course of said pathologies is characterized by scant lymph node metastases and by a marked tendency toward local evolution. Since symptoms are not particularly specific diagnosis is normally arrived at late (approximately 6 months after the first symptoms) when the disease is already in an advanced stage. The orbital area and its contents are quite difficult to study both from a clinical point of view and in terms of testing methodology. Orbital symptoms exist at onset in from 25-30% of the cases. On the other hand, when evaluated upon surgery, orbital invasion is encountered in 40% of the patients. Unfortunately radiology is not always able to provide all the information a surgeon requires in order to establish the proper approach. Although CT is able to provide information regarding extension of the lesion to the soft parts it is not equally able to confidently diagnose initial infiltrations into the bony walls of the orbita. A sampling of 31 patients with tumors of the nasal cavity and paranasal sinuses was studied. All subjects underwent careful radiological examination and were treated with a combination of surgery and radiotherapy. Upon clinical examination orbital invasion was suspected for 50% of the cases. Only in 40% of the cases did radiology confirm this while in 60% it was confirmed by surgery. It is worth noting that during surgery only half of the cases of such invasion were deemed as requiring orbitectomy.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMedDate not supplied

[Hypothyroidism following combined treatment of pharyngolaryngeal carcinoma].

The onset of hypothyroidism following surgery and/or radiotherapy for head and neck cancer varies from 25 to 67% and it is fostered by some clinical conditions. However, these percentages increase when one takes into consideration the latent hypofunctioning brought about by high levels of T.S.H. The present case study involves 15 laryngeal or pharyngolaryngeal cancer patients: 3 had undergone surgery alone although most of them had received a combination of radiotherapy and surgery. For these patients both the clinical conditions of any hypothyroidism and the laboratory parameters for thyroid function were studied. Of these the most significant proved to be T.S.H. The patients were monitored at 4 month intervals over the course of a year. In three of the 15 pharyngolaryngeal cancer subjects who had undergone a combined treatment including surgery and radiotherapy comparison of the parameters studied proved statistically highly significant (with an increase in T.S.H.). The damage sustained does not so much depend on the total dose of radiation but rather on the number of fractions employed. It may, therefore, be suggested that making changes in surgery to the detriment of oncological radicality is not worth while. It would appear that a different scheme for distribution of radiotherapy doses should, rather, be devised.

Adult↗
PubMedDate not supplied

[Diffuse symptomatic polypoid lipomatosis of the colon with hyperplasia of epiploic appendices: a case report].

Diffuse and symptomatic lipomatosis of the colon, particularly when associated with hyperplasia of the appendices epiploicae, is a rare disease. We report here the case of a lean, 26-year-old woman who had polypoid lipomatosis of the colon with submucosal and subserous expression (involving the mesentery and peritoneum) associated with extreme hyperplasia of the appendices epiploicae. Her disease led to a recurrent subocclusive syndrome which required total colectomy. We discuss the case and review the literature on this subject. The particular characteristics of this case and early onset of disease would suggest that our patient was affected by a congenital lipomatous syndrome linked to mesenchymal dysplasia. Long-term monitoring will enable prompt intervention in the case of reformation of lipomatous tissue.

Adult↗