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M Magyar

Publications and source records attributed to M Magyar.

10 recordsLinked to original sources
PubMed1990

[T gamma-lymphoproliferative disease].

The case of a rare type of T-cell malignant lymphomas, clinically with a relatively favorable course, a T gamma-lymphoproliferative disease (T gamma-cell chronic lymphocytic leukaemia) was presented. The cytomorphological, cytochemical, immuncytochemical and cytogenetical markers and functional tests of the peripheral blood lymphocytes from the patient were tested. The leukaemic cells with light- and electron microscopy showed the so called LGL (large granular lymphocyte) morphology with multifocal reactions of acid hydrolase enzymes. These cells also expressed IgG-Fc-receptor, CD 8 monoclonal antibody positivity and a monoclonally rearranged T-cell receptor gen expression. Functionally the patient's lymphocytes developed a blastic response to the T-cell mitogen Concanavalin A (ConA), they suppressed the immunoglobulin production of B-lymphocytes in co-cultures and had a normal NK-activity but decreased ADCC values. The patient was diagnosed by blood, bone marrow and lymph node examination and does not need any therapy. This case was published because of it's diagnostic, immunological and prognostical interests.

Antibodies, Monoclonal↗
PubMed1990

[Gene rearrangement in leukemia].

In this report we summarize our experiences based on the gene rearrangement study of 111 leukaemic patients of different kind. The lymphocyte DNA of the patients was studied for rearrangement of the immunoglobulin light chain constant-, the heavy chain joining- and the T cell receptor beta chain constant region. Our data have well supplemented the results of the monoclonal antibody experiments. In 33 cases the DNA study was in good agreement with the immunological data. In 42 our data helped in gave different results, immunological results. In 11 cases evaluating the DNA and immunological data indicating the necessity of further investigation. The results were inconclusive in 25 cases. As a conclusion we consider the gene rearrangement study to be useful for diagnostic purposes.

Adult↗
PubMed1990

Bigenotypic and biphenotypic appearance of immunoglobulin light chains in 1 of 3 non-Hodgkin's lymphoma xenografts.

Chromosomal analysis of three human non-Hodgkin's lymphoma (NHL) xenografts revealed common extra 14q+ segment and other individual clonal markers without involvement of immunoglobulin light-chain regions. Two NHL xenografts (HT 58 and HT 130) showed restricted lambda light chain expression and deleted kappa and rearranged lambda genes. However, in HT 117 both kappa and lambda chains were present on the cell surface, and both light chain genes showed rearranged alleles. This unique phenomenon could have resulted from either disturbed regulation of isotype exclusion or from the malignant transformation of light chain 'uncommitted' B cells.

Animals↗
PubMed1990

Clinical value of cytomorphologic, immunologic and cytogenetic investigations of acute leukaemias.

The valuability of immunophenotyping of acute myeloid and lymphoid leukaemias in comparison to morphological and cytochemical classification were approached in 56 cases. In the case of acute myeloid leukaemias the immunophenotyping by monoclonal antibodies CD14, CD13, CD33 was less informative concerning the subtypes of the disease. The clinical diagnosis can be achieved on the basis of cytochemical investigation alone. In contrast, the diagnosis of lymphoid leukaemias requires all information obtained by immunophenotyping by a series of monoclonal antibodies CD3, CD2, CD4, CD8, CD1, CD19, CD20, CD21 and CD10. On the other hand, the monoclonal antibodies are essential in differentiation of the very immature myeloid and lymphoid leukaemias. This is of great importance from the clinical point of view for determining the therapy. Molecular genetic studies based on the characterisation of the state of gene rearrangement of immunoglobulin and T-cell receptor beta chains have basic importance in the confirmation of the result of immunophenotyping and in the determination of leukaemias of unknown origin.

Acute Disease↗
PubMed1981

[Hygienic-bacteriological examinations in station restaurants (author's transl)].

In four station restaurants (West station, East station, South station, Kelenföld station) microbiological examinations were carried out in conjunction with the inspection of the hygienic conditions. The microflora of the washed and dried drinking glasses and plates as well as the smocks of the kitchen staff were examined. Intestinal bacteria, chromogenic bacteria and pathogenic staphylococci were found in numerous crockery samples. Therefore, it is necessary either to improve the effectiveness of the cleaning process or to prolong the drying of the crockery by heat. Numerous species, such as intestinal bacteria, chromogenic bacteria liable to cause food-decomposition were found in the kitchen staff's smocks, sometimes even in great quantities. To reliably determine the microbiological limit values for smocks and other textiles, a great number of examinations are still necessary. The smocks of the staff handling pre-cooked meals, cold meals or pastries must also be microbiologically clean.--The medical activity in the areas mentioned proved also beneficial to the training in hygiene.

Bacteria↗
PubMed1975

The role of alkalication in formation and decomposition of myosin-ATP complex.

The dependence of kinetic constants Km, V(k2) and k1 of myosin-ATPase on the species and concentration of alkali cations and on temperature was investigated. The value of Vvaries with the ionic radius of different alkali cations. The curve has a maximum at 1.33 A at the ionic radius of potassium. The detailed analysis of the cation dependence of the kinetics of the ATPose reaction shows that both formation and decomposition of the complex are affected by the cation present.

Adenosine Triphosphate↗