Biomedical subjects
M Mailloux
Publications and source records attributed to M Mailloux.
[Serological demonstration of the presence of Hantaan virus in Rattus norvegicus rats in an urban environment in France].
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[Identification of the first human Leptospira strain in the island of La Réunion].
The first Leptospira strain of the island of La Réunion isolated from a patient hospitalized at Saint-Pierre, is identified L. Icterohaemorrhagiae icterohaemorrhagiae. The importance and severity of leptospiroses in the island of La Réunion are to be emphasized.
[The immunologic diagnosis of leptospirosis: comparison of the ELISA technic with the agglutination-lysis reaction].
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[Surveillance of icterohemorrhagic leptospirosis in France (1974-1983)].
In France, between 1974 and 1983, 1 194 diagnoses of L. icterohaemorrhagiae leptospirosis were confirmed serologically at Pasteur Institute (Paris), WHO Reference Center. The number of cases diagnosed each year rose from 74 in 1974 to 277 in 1983. The annual incidence in 1983 was 0.55 per 100 000. The temporal distribution shows that 25% of cases were in August and 63% between July and October. Two areas have a greater incidence: the South West and the East. The departments near the sea of the South East, the North and the West have the lowest incidence.
[Seroepidemiologic study on leptospirosis in the Camargue region].
The damp environment and density of animal population in Camargue are good arguments for the study of leptospirosis. A serological and epidemiological survey on 642 blood samples revealed 36 (5.6%) with significant antibody titers. Icterohaemorrhagiae is followed by Canicola, Grippotyphosa, Australis and Ballum... The most endemic area is not Camargue but the area situated at the northeast (Basse-Durance). Women are twice more affected than men. These two results are not consistent with our initial hypothesis. It is always advisable to seek the etiology of fevers of unknown origin.
[Meningitis and meningoencephalitis caused by Leptospira. Apropos of 5 cases seen in Marseille during 1984].
The authors report 5 cases of leptospirosis with neurological symptoms. One case of polyradiculoneuritis, one case of meningoencephalitis, two of meningitis and a case a meningeal syndrome were observed. Three of these cases were contracted near Marseille, one in Singapour and one in Comores. The diagnosis was done by serology and the evolution was good.
[Biological diagnosis of the leptospiroses: technics and interpretations].
According to the chronological data of Physio-Pathology of leptospiroses, diagnosis is: Direct: isolation of the germ in the beginning of the acute phase of the disease: blood culture, culture of cerebrospinal fluid, animal inoculation. Identification is the work of a specialized laboratory. Indirect: demonstration of antibodies. Immunological tests are divided into two groups: Screening tests, available for all laboratories: they give an indication of Leptospirosis. They are carried out during the acute phase: slide macroscopic agglutination test, hemagglutination test, complement fixation test. Confirmatory tests, performed only by specialized laboratories. Interpretation is dependent on the case history of the patient.
Determination of the heat labile point of leptospiral antigens.
Pyrogenes Salinem antigen, prepared at different temperatures, is used to adsorb heterologous anti-Chiffon and anti-Pomona sera, and the lability point of the antigen is determined by the macroagglutination test. Results show that the effect of this thermolabile antigen starts to be destroyed after 10 min at 60 degrees C with anti-Pomona serum and at 65 degrees C with anti-Chiffon serum. The method of measurement is not sensitive enough and the lability point would probably be lower than that obtained in these tests. The authors consider a more accurate method to be the combined use of the adsorption and microagglutination tests, with comparative titration of an heterologous antiserum.
Late positive blood cultures in leptospiroses (report of four cases).
Leptospirosis in Tahiti was studied during 1981. 42 cases were detected by positive blood cultures grown in Stuart's medium. The present paper describes the isolation of leptospira from the blood of four cases 30 days after the date of onset.
Evaluation of the leptospiral protein-free medium.
Bey and Johnson's leptospiral protein-free medium is evaluated and some modifications to it are introduced. Different serovars have shown good growth in this medium, but generally it is necessary to adapt it before obtaining success. When adapted, the serovars, subcultured serially, have a long term survival, with a good bacterial density. Some serovars, such as tarassovi and grippotyphosa exhibited irregular results.
Leptospirosis in New Caledonia (Melanesia).
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Application of an immuno-enzyme technique to titration of antibodies in leptospirosis: ELISA (enzyme-linked immunosorbent assay).
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Leptospiroses in 1982 in France and French overseas departments.
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[Late positive blood culture in leptospirosis].
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About the presence of a thermolabile (TL) antigenic fraction in Leptospira interrogans.
Antisera prepared with living serovars of Leptospira interrogans have a fraction anti-TL able to neutralize TL antigen of Leptospira strains. After neutralization, any leptospiral serovar is able to adsorb heterologous antisera prepared with living strains.
Thrombocytopenia and renal failure in leptospirosis.
In a retrospective study of 60 cases of leptospirosis, the association of thrombocytopenia and acute renal failure as previously reported was confirmed. However, increased mortality, in our experience, was not associated with either thrombocytopenia or acute renal failure.