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Biomedical subjects

M Makai

Publications and source records attributed to M Makai.

4 recordsLinked to original sources

[Distribution of subtypes of viral hepatitis B antigen in areas of Rumania].

The results of subtyping the B antigen in 551 sera from patients with viral hepatitis, chronic evolutive hepatitis and cirrhosis, chronic carriers, donors and healthy subjects, were confirmed as positive HBAg by diffusion in agar, counterelectrophoresis and radioimmunology, and characterized by the d-y and w-r determinants by rheophoresis. The high incidence of the y determinant in all nine counties investigated probably reflects the prevalence of this serotype in Romania, recalling the distribution of subtypes observed in the south of Europe.

Adolescent

Hepatitis B antibodies in hospital personnel.

Sera from 544 hospital personnel members with different degrees of exposure to the agent of hepatitis B were tested for HB8Ag and anti-HB8 by counterelectrophoresis, radioimmunoassay and passive hemagglutination. The laboratory staff and persons having direct contact with patients exhibited a significantly higher prevalence of anti-HB8 (16.2%) as compared with the other groups: administrative staff (4.4%), healthy persons (4.6%) and blood donors (7.9%). These data prove the relationship between exposure to HB8Ag and anti-HB8 prevalence, more obvious in the laboratory staff handling human serum and plasma specimens (anti-HB8 incidence--25%).

Antibodies

Incidence of hepatitis B surface antigen (HBsAg) in some areas of Romania.

The incidence of HBsAg in several areas of Romania was studied by 253,460 routine determinations performed from 1973 to 1975. HBsAg incidence was of 1.5% in blood donors and reached the highest value in acute viral hepatitis patients undifferentiated according to the clinical form. The values obtained were in agreement with the results of other studies covering more limited zones of the country. Considerable differences in HBsAg incidence depending on geographic area were observed.

Adult