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Biomedical subjects

M Makek

Publications and source records attributed to M Makek.

At least 19 recordsLinked to original sources
PubMed2006

[Primary adenocarcinoma of the appendix as differential diagnosis of advanced ovarian carcinoma].

Malignant tumours of the appendix are rare. They are usually carcinoid tumours that must be distinguished from extremely rare adenocarcinomas. Metastatic mucinous adenocarcinomas of the appendix are only reported as case histories. In clinical terms, the tumours usually manifest themselves as acute appendicitis, as ruptured appendicitis, as a tumour in the right lower abdominal quadrant or as a pelvic tumour, which are generally mistaken for an ovarian tumour with the same sonographic image. Advanced primary adenocarcinomas of the appendix with ovarian metastases cannot be distinguished intraoperatively from a FIGO III ovarian carcinoma. The pathologist makes the definitive diagnosis. These characteristics also apply to the case presented here. Surgical therapy of the isolated primary appendiceal carcinoma consists of a hemicolectomy--an appendectomy in favourable cases--and, in the case of a metastasised carcinoma, according to the guidelines for an advanced ovarian or colon carcinoma. The effect of chemotherapy is insufficiently documented.

Adenocarcinoma, Mucinous↗
PubMed1995

Diagnostic accuracy of TMJ arthroscopy in correlation to histological findings.

From 1987-1993, 356 arthroscopic examinations of the temporomandibular joint were performed on 295 patients. During 69 examinations, biopsies were obtained to correlate arthroscopic findings with histology. In the overall group, histology confirmed in 78.9% the arthroscopic findings. Correlation was better in joints with degenerative changes (81.5%) than in those with a synovitic/hyperaemic appearance (61.5%). Chondroid metaplasia, detritus synovitis and synovial chondromatosis were additional diagnoses given by histological examination. In 11 joints, open arthrotomy was performed after arthroscopy with biopsy was carried out. The excised tissue was also investigated microscopically and correlates to the biopsy-result. Because no different pathological changes were found, it is concluded that biopsies performed during arthroscopy of the temporomandibular joint are representative for histological investigation. An additional perforation for introducing the biopsy forceps is not necessary, because results obtained with different techniques appeared to be equally accurate.

Adolescent↗
PubMed1991

[Actinomycosis--clinical and therapeutic considerations based on 2 personal case reports].

We report on two patients with actinomycosis. The first case was a 45-year-old cachectic man with extensive bilateral pulmonary infiltrates. The lesions remained unclear for 18 months and only open lung biopsy with microscopic and cultural evaluation led to the diagnosis of actinomycosis. In the second case, classic cervico-facial actinomycosis in a 69-year-old farmer is described. Diagnosis was established on the basis of microscopic findings of "sulphur granules" eroding the mandible. Furthermore, the clinical presentation, with an indurated swelling of the jaw and intraoral fistula formation, was typical. The patient had a severe combined aortic valve lesion and died after ventricular fibrillation during hospitalization. Diagnosis could not be confirmed by culture, probably due to antibiotic prophylaxis against endocarditis during tooth extraction on the first day of admission. Diagnostic difficulties and microbiologic aspects are discussed, with special focus on the rare species of Actinomyces meyeri which was cultured from biopsy specimens from the lung of the first patient. So far this species has been described in only 13 patients.(ABSTRACT TRUNCATED AT 250 WORDS)

Actinomycosis↗
PubMed1991

Malignant melanotic schwannoma of the oral cavity.

Intraoral malignant melanotic schwannoma is an extremely rare tumor. Two cases are presented, one occurring in the mandible of a 62-year-old man, the other in the maxilla of a 79-year-old man. The clinical presentation, light microscopic findings and immunohistopathological features are described. The difficulty of diagnosing this special tumor at initial presentation correctly, is discussed.

Aged↗
PubMed1991

[The ameloblastic fibro-odontoma].

The ameloblastic fibro-odontoma is a rare nonagressive mixed odontogenic tumor. Most of these lesions occur in patients under 20 years. There is no sex predilection. They are located more often in the mandible, usually in the posterior segment. Painless swelling in the most common clinical sign. Radiologically, ameloblastic fibro-odontomas show a circumscribed radiolucency which contains radiopaque foci of various sizes and shapes. Histological examination reveals fibrous soft tissue and islands of odontogenic epithelium. The tumor produces enamel or enamel matrix, dentin and cementum. Treatment of ameloblastic fibro-odontomas usually consists of enucleation or surgical curettage. Eight cases of ameloblastic fibro-odontoma are reported and the clinical features, radiographic and histo-pathologic findings will be discussed along with the 67 cases found in the literature.

Adolescent↗
PubMed1990

Neural infiltration of glomus temporale tumors.

Biologic behavior of glomus temporale tumors in relation to cranial nerve infiltration remains unclear. An analysis of cranial nerve involvement in relation to tumor staging was undertaken in a series of 102 glomus temporale tumors. Frequent neural infiltration was noted to occur in large glomus tumors, and a grading system of infiltration with both pathologic and surgical relevance introduced.

Adolescent↗
PubMed1989

Preauricular pilomatrixoma: a diagnostic pitfall.

Although pilomatrixomas are well known to dermatologists and dermatopathologists, surgeons encountering these lesions over the parotid gland frequently do not consider this benign neoplasm in the differential diagnosis. Presentation of a subcutaneous preauricular lesion, coupled with an erroneous cytologic diagnosis of malignancy, can potentially result in histologic "overdiagnosis" and more aggressive therapy than is required for these benign hair follicle neoplasms. A case is reported to illustrate this potential diagnostic trap, and a series of 206 cases collected at the University Hospital of Zurich from 1975 to 1987 is reviewed.

Adolescent↗
PubMed1989

Lesions of Rathke's duct: another indication for the infratemporal fossa approach.

Rathke's duct is a midline structure, arising from the primitive stomodeum and extending upward to the hypophysis. The duct, which normally involutes in utero, may persist on occasion. This most frequently results in intracranial disease. Occasionally, disease may become manifest in the extracranial skull base. We present three such cases: cystic craniopharyngioma, Rathke's cleft cyst, and a persistent cerebrospinal fluid rhinorrhea caused by a patent craniopharyngeal canal. Each lesion involved the clivus and the parasphenoid region. Surgical management of such lesions requires not only extirpation of disease, but also the ability to recognize and preserve the many important regional structures. The procedure that best allows for the wide exposure necessary to accomplish these goals is the infratemporal fossa approach to the lateral skull base.

Cerebrospinal Fluid Rhinorrhea↗
PubMed1989

The significance of sinus elevation for blade implantology--report of an autopsy case.

This paper describes the histopathological examination of an autopsy case featuring reconstruction of an edentulous maxilla by means of uncoated blade implants made of Titanaloy (TI6AL4V) inserted by the first author two years and seven months prior to the patient's death. The naturally induced reparative processes which encourage the success of this method and the optimal geometric flexibility allowed by the use of delicate blades are also examined. The significance of fibro-osseous tissue in blade implant support systems and the term "osseo-integration" often used in implantological literature will be discussed. The present study allows the following conclusions to be drawn: (1) Blade implants can be made in the maxilla. Provided sinus elevation is performed, blade implantation is feasible even when only minimal vertical quantities of bone are available in the distal regions. (2) Even if the opposing jaw bone (in this case the mandible) presents a complete natural dentition, blade implantation therapy remains feasible. (3) As the findings in this study show, the dynamic formation of calcified and non-calcified connective tissue around and within an endosseous implant is a totally natural reaction ensuring (a) fixation, (b) shock absorption, (c) the prevention of infection, and (d) the prevention of epithelial downgrowth. (4) Properly placed blade implants can be subjected to functional loading after six post-operative weeks and do not require a two-stage operative process, with a healing period of three to four months between the first and second surgical interventions. This often-cited three-to-four-month ossification period is thus unnecessary. (5) This case study clearly refutes the claims made by some authors (Tetsch, 1983; Strunz and Tetsch, 1985; Schramm-Scherrer and Tetsch, 1986) to the effect that (1) the maxilla cannot be implanted, and (2) blade implantology is doomed to failure, whether practiced in the maxilla or the mandible.

Blade Implantation↗
PubMed1988

Histology of synthetic ossicular prostheses.

Thirty-three synthetic middle ear prostheses removed after two to 99 months of implantation were examined histologically. All prostheses were infiltrated by fibroblasts, capillaries, collagen fibrils, and multinucleate foreign body giant cells. Although some of the giant cells contained tiny particles of the prosthetic material, there was no evidence of erosion or engulfment of larger particles of the prosthesis or structural dissolution of the prosthesis. New histologic findings were aseptic necrosis and focal calcification in the interior of some of the prostheses.

Ear, Middle↗
PubMed1988

Epithelial-myoepithelial carcinoma of the parotid gland associated with a primary carcinoma of the lung.

We describe the case of a 64-year-old man who presented with a rare salivary gland tumour, an epithelial-myoepithelial carcinoma. This was removed but recurred and required further surgery and radiotherapy. At the time of the patient's 2nd admission, a further primary tumour was detected. This proved to be a primary mixed adeno and squamous carcinoma of lung: a thoracotomy was performed and a lobectomy. The patient died suddenly 11 months later because of cor pulmonale. We describe the histology of epithelial-myoepithelial carcinoma and the immunohistochemical appearances of the tumour on staining for S-100, vimentin and keratin. The literature on this lesion is reviewed and radical surgery with post-operative radiotherapy are recommended as the best therapeutic approach. The literature on coincident second primary tumours in patients with salivary gland neoplasia is also reviewed. This is only the second case in which this phenomenon has been observed with epithelial-myoepithelial carcinoma.

Adenocarcinoma↗