Biomedical subjects

M Malinge

Publications and source records attributed to M Malinge.

21 records · Page 2Linked to original sources

PubMed1979

[Total replacement of an arm amputated near the shoulder. Difficulties during anesthesia and ressuscitation (author's transl)].

The authors report a recent observation of the total replacement of an arm amputated near the shoulder. The limb was perfused and cooled down from the site of the accident to the general hospital (distance about 50 miles) and was replanted within 13 hours. The procedure itself lasted about 8 hours. The bone replantation was the most critical difficulty for the surgeons. Venous repair was associated with hemorrhage and massive transfusion had to be performed to compensate heavy blood loss. In the post-operative period acute renal insufficiency and septicemia developed. After ten days an arterial rupture occurred and emergency amputation was performed. Recovery was uneventful and the patient was discharged nine weeks after his admission, his renal function being quite restored. The authors compare the hazards of this kind of operation and the chance of recovery of the functions of a replanted limb. They conclude by emphasizing the necessity of carefully choosing the cases for total arm replacement.

Adult↗

PubMedDate not supplied

[Mechanism of action of clonidine in the forced-swimming test in mice].

Clonidine displays immobility-reducing effects in the mouse swimming model at doses (0.06-16 mg/kg IP) which decrease spontaneous motility. Tricyclic antidepressants evoke a similar dissociation in motor activity. The immobility-reducing effect of clonidine (1 mg/kg at 30 min pretesting) was reversed by yohimbine (4 mg/kg) but was unaffected by prazosin (2 mg/kg) or alpha-methyl-paratyrosine (100 mg/kg), and was enhanced by reserpine (2.5 mg/kg). Mediation by alpha-2 postjunctional receptors was thus suggested. However, two 5-HT receptor blockers--methysergide (2 mg/kg) and ketanserin (8 mg/kg)--increased this effect of clonidine whereas the non selective agonist 5-MeODMT (1 mg/kg) reduced clonidine action. Conversely, pretreatment with a subthreshold dose of clonidine (0.06 mg/kg at 45 min pretesting) made effective subthreshold doses of three 5-HT uptake inhibitors (citalopram 2 mg/kg, indalpine and fluvoxamine 4 mg/kg) and of the 5-HT1 receptor agonist 8-OH-DPAT (0.5 mg/kg). According to these data, the mouse swimming model would trigger functional relationships between central alpha-noradrenergic and serotonergic mechanisms.

Animals↗

PubMedDate not supplied

Provocative agents in panic disorder.

The pharmacological challenge strategy involves giving a provoking agent under controlled rules to clarify some aspect of behavioural or biological function. Various agents such as sodium lactate, carbon dioxide, caffeine, yohimbine, isoprenaline and now cholecystokinin have been used as provoking agents in healthy volunteers as well as in panic patients. Results obtained in this field are updated, with emphasis on the potential mechanisms of action. It is concluded that there may be a final pathway between carbon dioxide, sodium lactate, and cholecystokinin inducing panic attacks.

Caffeine↗