[Arterial vascularization of the intumescentia lumbalis and conus medullaris].
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Arteries↗
Biomedical subjects
M Maliszewski
Publications and source records attributed to M Maliszewski.
[Vascular regions of the spinal cord].
In a material of 50 spinal cord specimens obtained from adults the radicular-anastomotic arteries were studied. After an analysis of the situation, diameter and connections of these arteries seven vascular regions were discerned in the cord: upper cervical region C1-C3, middle cervical region C4-C5, cervical intumescence region C6-C8, upper thoracic region Th1-Th3, middle thoracic region Th4-Th7, thoracolumbar intumescence region Th8-L4, and lumbosacral region L5-Co. Arterial systems found in these regions are described.
Adult↗
Zidovudine pharmacokinetics in HIV-positive women during different phases of the menstrual cycle.
STUDY OBJECTIVE: To examine the pharmacokinetics of zidovudine during the menstrual cycle in human immunodeficiency virus- (HIV-) positive women. DESIGN: Open, unblinded study. SETTING: A women's clinic for acquired immunodeficiency syndrome (AIDS) at a large medical center. PATIENTS: HIV-positive women with a CD4+ cell count above 200/mm3, receiving long-term zidovudine therapy, with a history of regular menstrual cycles. INTERVENTIONS: All patients received a 100-mg dose of zidovudine in the fasted state on three occasions. MEASUREMENTS AND MAIN RESULTS: Zidovudine and zidovudine-glucuronide plasma concentrations were measured with radioimmunoassay to determine the pharmacokinetic characteristics during each menstrual phase. The drug's mean peak plasma concentrations (range 233-808 ng/ml) were 556 +/- 145, 385 +/- 132, and 495 +/- 143 ng/ml during the menstrual, late follicular-ovulatory, and luteal phases, respectively. Initially, plasma concentrations declined in a linear fashion from 0 to 4 hours, with a prolonged elimination phase in many patients after 4 hours. The mean zidovudine area under the curve was 886 +/- 156, 845 +/- 268, and 775 +/- 167 ng.hour/ml. The mean percentage of dose recovered was 44.2 +/- 26.0, 56.9 +/- 19.1, and 42.2 +/- 16.6, respectively. CONCLUSIONS: The pharmacokinetics of zidovudine were not different during the three phases of the menstrual cycle; however, considerable intrapatient and interpatient variability was noted for many of the values.
Adult↗
[A case of lumbar glomeruloma].
A case of the patient with atypical localization of glomus tumor in lumbar region is reported. Trigger pain of unusual intensity resistant to pharmacological treatment ceased immediately after the operation.
Brain↗
[Extramedullary erythropoiesis in cerebellar hemangioblastomas].
Three patients operated on for cerebellar haemangioblastoma are reported. Rarely observed extramedullary erythropoiesis was found in tumour tissue. One patient had erythrocytosis (solid form of the tumour), the remaining patients with cystic tumour had normal erythrocyte count.
Aged↗
[Views on the etiology and pathogenesis of intracranial saccular aneurysms].
The anatomical structure of intracranial arteries may favour the development of aneurysms because of poorly developed external elastic lamina and adventitia, gaps in the muscular layer and great number of collagenous fibres. However, the haemodynamic factor has the principal significance in initiation, growth and rupture of the aneurysms. The importance of this factor is especially great in cases of coexistence with developmental abnormalities of the arteries, arterial occlusion, hypertension, atherosclerosis or hereditary connective tissue disorders.
Humans↗
[Assessment of cerebral blood flow velocity changes by transcranial Doppler examination in patients with closed craniocerebral trauma].
24 patients after minor or moderate, closed isolated head injuries and 10 patients of control group were included to this study. Right after admission blood flow velocities of both middle cerebral arteries (MCAs) by using transcranial Doppler method (TCD) and blood flow velocities of both extracranial parts of internal carotid arteries (ICAs) by "duplex-scan method" were examined. Changes in mean flow velocities (MFVs) in MCAs and ICAs, VMCA/VICA ratio were analysed. 40% of patients who had minor or moderate head injury demonstrated increase of MCA velocity homolateral to the trauma or bilateral. We observed cerebral hyperemia in 16.7% of patients and posttraumatic vasospasm (TVSP) in 25% of patients. There is a high risk of occurring TVSP in patients with CT shows evidence of subdural or intracerebral hematoma.
Adolescent↗
[The use of pedicle periosteal flap in plastic surgery of anterior skull base].
In 12 cases of large traumatic defects of the anterior skull base plastic surgery was performed using large periostial flap to separate the nasopharynx from the extradural area. After a large biauricular scalp flap was formed, precise preparation of periostial flap was done. The bifronto-transfrontal sinus or transfrontal sinus approach was performed. Next cranialization of the frontal sinus was done and then it was filled with muscle. Afterwards the floor of the frontal sinus and skull base with defect were covered with periostial flap pedicled along supraorbital ridge. Finally irradiated homograft of dura or fascia lata was glued intradurally onto the place of the dural defect. In all of the patients CSF-rhinorrhea stopped immediately after surgery. Among patients observed from 2 to 4 years after surgery neither recurrent rhinorrhea nor infection appeared.
Adolescent↗