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Biomedical subjects

M Mall-Haefeli

Publications and source records attributed to M Mall-Haefeli.

At least 19 recordsLinked to original sources
PubMed1991

[Clinical experience with Mercilon and Marvelon with special reference to ovarian function].

The effects of two oral contraceptive combinations either containing 0.020 mg ethynilestradiol (EE) + 0.150 mg desogestrel (Mercilon) or 0.030 mg EE + 0.150 mg desogestrel (Marvelon) were compared in two independent trials. Special attention was paid to serum levels of LH, FSH, prolactin, progesterone, testosterone, estradiol, SHBG in the first and efficacy, cycle control and tolerability in the second trial. The first trial included 71 women. Serum levels were determined in the cycle before treatment, in the third and sixth cycle of treatment and one cycle after treatment. The following difference was found: Women using the lower dosed preparation showed significantly less suppressed FSH values compared to women using Marvelon. Mean values of Estradiol and Progesterone were significantly suppressed 30% of our measurement in the lower dosed data sample showed extremely high Estradiol and Progesterone values. SHBG has increased by 200-300% and had no effect on prolactin and testosterone levels. In the second trial 781 women (5193 cycles) were evaluated. Assessment were made in the first, third and twelfth cycle of treatment. There were no marked differences between the two preparations with respect to normalisation of cycle length, bleeding duration and intensity. Differences occurred in frequencies of silent menstruation and breakthrough bleedings. They were more often by receiving 0.020 mg EE (7.7%, Mercilon) than with 0.030 mg EE (3.6%, Marvelon). With 0.020 mg EE a higher percentage of women showed body weight change. Blood pressure remained stable in both groups. Both preparations were very good tolerated with slightly more breast tenderness by taking 0.030 mg EE.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1988

Intrauterine occlusion body (IUB). Preliminary report.

The IUB or SOF-T is a further development of the IUD with additional functions and properties. In 368 IUB insertions over a period of 48 months, there was no intrauterine pregnancy. There was a low removal rate due to bleeding, pain, infection or partial expulsion in 277 insertions performed at two university centers over an average period of 8-1/2 cycles. In 80 cases tubal occlusion was directly or indirectly proven by different methods. The improved ultrasound localisation of the IUB is possibly responsible for its effectiveness and the soft ends are probably the main reason for its improved tolerance compared to other IUDs.

Adult↗
PubMed1987

[Prevention of pregnancy in adolescents and premenopausal females].

The norms of our society have changed in the last decades. This also concerns our general attitude towards sexuality. Professional demands on the parents, increasing material independence of adolescents, excessive exposure to external stimuli lead to sexual contacts at a very early age. Contrary to a more accelerated physical development, which manifests itself in a progressively earlier puberty, psychic development is retarded. According to numerous studies pregnancies in adolescents do not show increased somatic complications. They do, however, influence the psychic maturation of the adolescents in a negative way. Whereas the necessity for sexual education is unquestioned, the efficacy is doubtful. Knowledge of contraception and its correct use is not enough to avoid undesired pregnancies. The psychic structure of the individual may often lead to an undesired pregnancy. Therefore, we recommend for adolescents contraceptives which are reliable, without negative effect on fertility and with neglibile side-effects. The number of failures and the inconvenience realted to their use make conventional methods unacceptable. The danger of PID and the risk of later sterility contraindicate the use of IUD in adolescents. Today the method of choice is a low-dose contraceptive which contains a gestagen of the third generation. The premenopausal state is the time in which cycles become irregular and in which an increasing hormonal insufficiency is observed. Therefore, women over forty years need reliable contraception as well as hormonal substitution. Increase of cardiovascular risk was observed in women when high-dose contraceptives were given. This was obvious in the more than forty year old women taking the pill.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1979

[Comparative clinical investigation of oral contraceptives with different doses (author's transl)].

The investigation of four oral contraceptives with different doses in adolescent girls showed that bleeding disturbances occur more frequently with low-dose preparations at the beginning of treatment. Nevertheless, these disturbances should be considered indicative of lesser central suppression. For this reason adolescent girls -- especially those with still immature cycles -- should be treated chiefly with preparations having only a low inhibitory effect on the central endocrine system in order not to disturb the maturation of the cycle.

Adolescent↗
PubMed1979

[Comparative catamnestic investigations concerning the psychological effects of sterilisation (author's transl)].

In a comparative catamnestic study the emotional working-through of sterilisation in 3 groups of 33 women was examined (duration of catamnesis: 10-12, 5, 2 years). Whereas in all the 3 collectives the upper lower class (according to Bolte) is represented the most frequently (58% in the 1st and the 2nd, 52% in the 3rd), as far as the lower middle class is concerned there is a higher fraction in the 3rd collective (p less than 0,05) and of the middle class there is a higher fraction in the collectives 1 and 2 (p less than 0,05). Women with a higher income (p less than 0,01) and with a better school and professional (p less than 0,05) training are overrepresented in the 2nd and 3rd collective. In the 3rd group only 6% indicated a religious bond, in comparison to 55% in the 1st and 49% in the 2nd group (p less than 0,01). Women of the 2nd and the 3rd collective were in comparison to those of the 1st group older (p less than 0,01) when they were sterilised, and had less children (p less than 0,05-0,01). In the 3rd group there were more divorced women (18%) in comparison to 3% in the 2nd and 0% in the 1st group (p less than 0,01). Concerning the indication for sterilisation medical-psychiatric causes were preponderant with 42% in the 1st group in comparison to 24% in the 2nd and 18% in the 3rd group (p less than 0,01), whereas in the 2nd group (61%) the social indications were predominant. The immediate cause for sterilisation was represented in the 2nd and the 3rd collective preponderantly by the desire to replace the hormonal contraceptives (p less than 0,01). The 1st collective mainly used insecure contraceptive methods before the operation, the 2nd and 3rd principally hormonal methods (p less than 0,01). In the 1st group it was mainly the insecurity of the method, in the 2nd and the 3rd there were more frequent side effects or contraindications (p less than 0,01), which caused the dissatisfaction with the anticonceptive method. The 3 groups differed significantly concerning the catamnestic evaluation of sterilisation. 100% of the last, 94% each of the 2nd and 3rd were satisfied concerning the sterilisation. To the question of working-through of sterilisation concerning psychic, somatic and especially sexual effects, most of the women in all the 3 groups responded favourably.

Adult↗