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Biomedical subjects

M Mandelcorn

Publications and source records attributed to M Mandelcorn.

12 recordsLinked to original sources
PubMed1999

Risk factors for pain and nausea following retinal and vitreous surgery under conscious sedation.

BACKGROUND: There have been no studies examining risk factors for pain and nausea during the first day after posterior segment surgery. We performed a study to identify significant risk factors for the development of pain and nausea during the first 24 hours after outpatient vitrectomy or scleral buckle surgery. METHODS: A total of 257 consecutive patients who underwent vitrectomy (192 patients), scleral buckling (57 patients) or combined vitrectomy-scleral buckling (8 patients) between July 1 and Dec. 31, 1995, were enrolled in this prospective study. The patients' age, sex and ethnicity, the duration of the procedure and the intraoperative use of minor tranquillizers, hypnotic agents, narcotic analgesics or major tranquillizers were recorded. Each patient rated his or her postoperative pain and nausea on two separate 100-mm lines. The left end of the line represented no pain (or nausea) whatsoever, and the right end of the line represented severe pain (or nausea). The distance of the recorded point from the origin of the line was used as the outcome measure for pain and nausea. All the data were analysed statistically by means of logistic regression analysis and descriptive statistics. RESULTS: The median pain scores were 1.0 for the patients who underwent vitrectomy, 47.0 for those who underwent scleral buckling and 35.0 for those who underwent combined vitrectomy-scleral buckling. The median nausea scores were 14.5, 45.0 and 55.5 respectively. The only variable that was identified as a predictor of postoperative pain or nausea was the intraoperative use of narcotic analgesics: in the vitrectomy group, postoperative nausea occurred almost three times as often among patients who received these agents as among those who did not (odds ratio 2.6, p = 0.00). INTERPRETATION: The identification of the intraoperative use of narcotic analgesics as a risk factor for nausea in the first 24 hours after outpatient vitrectomy suggests that, when possible, these agents should be avoided during surgery.

Adolescent↗
PubMed1991

The structure of the developing chick retinal pigment epithelium revealed by high resolution scanning electron microscopy.

The retinal pigment epithelium (RPE) in the developing eye of chick embryos has been studied during the early stages of development by high resolution scanning electron microscopy (HRSEM). Specimen preparation techniques which involve removal of the cytoplasmic matrix permitted visualization of organelles and other subcellular structures within RPE cells in detail and in three dimensional (3-D) stereo HRSEM. Using this technique, we were able to examine changes in melanosome structures during development and demonstrate that pigmentation in the RPE was present by day 4 of development. RPE plasma cell membranes showed extensive folding of the apical portion of the membrane closest to the developing neural retina by day 9. Examination of RPE photoreceptor junction revealed photoreceptor inner segments by day 6 and an outer segment by day 9. Mitochondria in the RPE were found to contain tubular cristae only. The ultra-structure in 3-D of the Golgi apparatus, smooth and rough endoplasmic reticulum, lysosomes and nuclear chromatin of the RPE, and Bruch's layer was revealed by the HRSEM method.

Animals↗
PubMed1979

Eccentric serous choroidopathy: a case report.

A patient presented with a serous detachment of the retina outside the macular region in one eye and three years later a similar detachment in the fellow eye. The clinical findings were otherwise identical to those seen in patients with idiopathic central serous choroidopathy. Idiopathic eccentric serous choroidopathy is probably a variant of idiopathic central serous choroidopathy. Its occurrence may be implications in understanding the pathogenesis of the latter condition.

Adult↗
PubMed1979

Vitreous and retinal surgery in pseudophakia.

We review scleral buckling and vitrectomy procedures in thirteen pseudophakic eyes. Pre-operative difficulties in visualizing the fundi were few. Despite operative complications due to the implant, 90% of the retinas were reattached. Late complications involving particularly the anterior segment in both the buckling and vitrectomy groups caused the poor visual results.

Aged↗
PubMed1977

Computed tomography of choroidal melanoma and scleral buckle.

In the investigation of a patient with choroidal melanoma in one eye and repaired rhegmatogenous retinal detachment in the other, a C.T. scan demonstrated the tumour in the right globe and the encircling silastic sponge around the left globe. These radiologic findings were confirmed on histological examination of the right eye. We believe C.T. scanning may be a valuable technique for investigating bulbar and para-bulbar soft tissue abnormalities.

Adult↗
PubMed1976

Results after vitrectomy in diabetes.

Eighteen eyes in seventeen patients with diabetic retinopathy were operated on using the vitreous infusion-suction cutter. All had severe loss of vision due to retinal detachment or vitreous hemorrhage, or both. Thirteen eyes had a significant improvement in vision. The surgical management and postoperative problems are described. The results suggest that this technique is useful in selected cases of blindness caused by diabetes.

Adult↗