PubMed Health⌕ Search

Biomedical subjects

M Maneschi

Publications and source records attributed to M Maneschi.

At least 19 recordsLinked to original sources
PubMed1992

Surgical pathological staging of endometrial carcinoma and results of treatment.

114 women with endometrial carcinoma at clinical stage 1 to 3 were treated with surgery as first line of treatment. Patients were classified as being low or high risk on the basis of the surgical pathological patterns of the tumor. Disease limited to the uterine body, G1-G2 tumors and myometrial invasion of less than 1/3, identified low risk patients which received no adjuvant therapy. All the others were considered high risk and treated with radiation therapy. Patients were retrospectively restaged according to 1988 FIGO guidelines and survival was analyzed. Cox's proportional hazards method was employed to identify independent prognostic factors. Disease free survival (DFS) was 90% for stage 1, 83% for stage 2, and 43% for stage 3 patients. Lymphatic spread was associated to the poorer prognosis. Proportional hazards model showed that tumor grading, myometrial invasion and lymphatic spread were significantly related to the time of relapsing. Low risk patients showed better outcomes despite not having received adjuvant treatment, thus post-operative therapy is not indicated in this subset of patients. Radiation adjuvant therapy for high risk patients did not give satisfactory results. Failures were observed both locally and distantly calling for new adjuvant strategies. Surgical pathological staging of endometrial cancer is currently mandatory. Retroperitoneal lymph node sampling is indicated in patients with high risk pre- (advanced clinical disease, undifferentiated tumors) or intra-operative (deep myometrial invasion, enlarged pelvic nodes) prognostic factors. All prognostic indicators must be obtained from surgery and pathology in order to assess the risk of relapse.

Adult↗
PubMed1991

Reproductive performance in women with complete septate uteri.

Of 11 women with a diagnosis of complete septate uterus, 7 did not undergo any surgical correction, whereas 4 underwent metroplasty. The diagnosis was made in eight cases (73%) for reasons not related to the anomaly. In only three cases did the patients present with infertility complaints. Eight patients, one of whom was subsequently treated, had a total of 13 pregnancies, 3 (27%) of which ended in abortion, 4 (31%) in premature delivery and 6 (42%) in term births, for a live birth rate of 61.5%. The cumulative pregnancy rate was 80% at 12 months. The cumulative probability of carrying a pregnancy to term and giving birth to a live infant was 75% and 88%, respectively, for the second pregnancy. After metroplasty one patient still did not conceive, while three had a total of five pregnancies, one of which ended in abortion and four at term, for a live birth rate of 80%. With a complete septate uterus the ability to conceive is preserved, and the gestational ability is impaired only moderately. Metroplasty, if indicated, can yield good results in terms of the live birth rate.

Abortion, Spontaneous↗
PubMed1980

A new technique of vaginal colpopexy.

The correction of a total or partial vaginal prolapse after hysterectomy is often difficult to perform, particularly when the possibility of sexual intercourse must be preserved. A method of vaginal retropubic colpopexy is proposed. In addition to preserving the vaginal functionality, it can be performed for preventive purposes during hysterectomy for uterine prolapse or conspicuous cystorectocele and finally, it corrects the topographic modification of the bladder and of the urethra. This method has had excellent results on 18 patients and relapse has not occurred after two or three years.

Female↗
PubMed1977

Diagnostic problems on nosographic classification of polycystic disease of the ovary.

Nineteen patients with polycystic disease of the ovary have been studied. From the humoral point of view the group was found to consist of two populations distinguishable from one another by their basal LH levels. In type I cases LH was definitely increased (M = 53.46 +/- 12.79 mIU/ml) whereas FSH (M = 8.10 +/- 0.74 mIU/ml), prolactin (M = 10.48 +/- 2.12 ng/ml), 17beta-estradiol (M = 124.76 +/- 11.21 pg/ml), progesterone (M = 0.321 +/- 0.078 ng/ml) were all within the normal range for the follicular phase of the menstrual cycle. Testosterone levels were raised (M = 121.15 +/- 24.55 ng/100 ml) but not to an extent significantly different from that of patients with type II disease (M = 119,5 +/- 33.53 ng/100 ml). All the other hormonal parameters were within the normal range also in type II disease; for LH the difference between the means of the two groups was statistically significant (p less than 0.01). Urinary 17-ketosteroids were not significantly different in the two groups of patients and the values found always fell within the normal range for our laboratory. LH-RH stimulation (50 microgram i.v.) elicited an exaggerated response in type I and a normal one in type II. The FSH response was always deficient and delayed in both groups. Since there was no correlation of the humoral data to the macroscopic aspect of the ovary as visualized by celioscopy, the practical importanze of endocrine exploration of these cases is stressed, especially as regards LH levels and androgen secretion, at least for the identification of cases in which polycystic disease of the ovary is suspected.

Adolescent↗
PubMed1977

Endocrine modifications in women with premature menopause.

The Authors have found 9 cases of premature menopause out of a total of 159 observations of gynecological disfunctional disorders for a 3 year period. The functional investigation has been carried out by radioimmunoassay for PRL, FSH, LH, 17beta-estradiol, progesterone and, in those cases in which it was possible, the spontaneous pulsatility of PRL and gonadotropins has also been studied. The basal PRL was found always in normal range and the pulsatility was sufficiently flat. On the other hand a pool of gonadotropins can still be released by 100 microgram of LH-RH i.v. in spite of high basal levels of pituitary gonadotropins. The pulsatility, especially for FSH, appears like to those of postmenopausal women. 17beta-estradiol and progesterone were at low levels and could not be alterated by HMG-HCG tests. As a conclusion the Authors think that the evaluation of the above reported parameters is an unfailing diagnostic precision in many cases of secondary protovarian amenorrhea for a premature menopause syndrome.

Adult↗