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M Manganaro

Publications and source records attributed to M Manganaro.

49 records · Page 3Linked to original sources
PubMedDate not supplied

Correlation between a psychometric test and biochemical indices of hepatic encephalopathy in alcoholics.

BACKGROUND/AIMS: In alcohol abusers an alteration of responses to psychometric tests has been reported, even when clinical symptoms of hepatic encephalopathy (HE) are absent. Our research was intended to individualize a simple psychometric test, easy enough to be performed also at the patient's home, able to reveal an impending encephalopathy and, consequently, to facilitate earlier treatment. METHODOLOGY: Twenty-six consecutive male alcoholics were engaged and, after informed consent, the following schedule was applied: administration of a psychometric test, followed by a drawing of blood for the determination of many blood parameters. After 15 days of treatment to detoxicate patients, psychometric tests and blood examinations were repeated. RESULTS: The results confirmed that common blood examinations are not useful to monitor brain damage in chronic alcoholism, that a psychometric test is able to demonstrate a therapeutic improvement and that a positive and significant correlation has been observed between BBCA/AAA ratio and WAIS Score. CONCLUSIONS: These preliminary results suggest that it is possible to suspect dangerous biochemical changes by means of a simple psychometric test.

Adult↗
PubMedDate not supplied

[Metabolomics and medical practice].

High resolution NMR spectroscopy, currently known as "metabolomics", is a technology enabling the rapid, noninvasive and low cost determination of low molecular weigh metabolites (e.g. aminoacids) in biological fluids such as plasma, urine, saliva, cerebrospinal fluid and others. According to Nicholson "Metabolomics is the quantitative measurement of the dynamic multiparametric metabolic response of living systems to pathophysiological stimuli or genetic modification". Over the past 10 years this technology made it possible to discover of a number of lesser-known organ-specific metabolites that has been demonstrated to be reliable indicators of both organ function and viability. Consequently metabolomics has been used, with interesting results, for the functional evaluation of many organs (kidney, liver, heart), drug toxicity and post-transplant monitoring. The international literature demonstrates a growing interest for this technology and its capabilities.

Drug Monitoring↗