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M Manis

Publications and source records attributed to M Manis.

2 recordsLinked to original sources

Comparison and expectancy processes in human judgment.

This work explored a judgment model proposed by Manis and Paskewitz (1984a). The model suggests that prior experience with the members of a given category affects the assessment of other category members in 2 ways: (a) by providing a basis for comparison and (b) by leading the judge to expect that new exemplars will resemble those previously encountered. In 4 experiments, respondents judged the height of different people on the basis of full-length photographs. The height of the models in an induction series constituted the main independent variable. The effects of contrasting inductions (e.g., short vs. tall women) affected the judges' subsequent assessments in a test series. Both comparison and expectancy processes played a significant role, sometimes opposing one another and sometimes acting in parallel (i.e., supporting one another).

Female

Human N-acetylation genotype determination with urinary caffeine metabolites.

The human acetylation genotype was determined by measuring urinary caffeine metabolites by use of a modification of a previously published HPLC method. The problem of separation of 7-methylxanthine (7X) from 1-methyluric acid (IU) in urine extracts was achieved by adding a phenyl column, in tandem with a C18 reverse-phase column, by means of a methanol:aqueous acetic acid gradient elution system. The urinary molar ratios of (AAMU)/(AAMU + 1U + 1X) and (AAMU)/(1X) were estimated in 20 subjects phenotyped with dapsone, with 100% concordance for the [AAMU]/[1X] ratio. A population study of 42 unrelated individuals exhibited trimodal distribution in acetylation capacity, consistent with the Hardy-Weinberg theory of population genetics. Definitive pedigree analysis of 16 families (75 subjects) resulted in significant similarity between the observed genotypic matings and those expected by classical Mendelian segregation. This noninvasive genotyping method promises to be useful in future investigation of the relationship between the human acetylation polymorphism and clinical disorders.

Acetylation