PubMed Health⌕ Search

Biomedical subjects

M Mano

Publications and source records attributed to M Mano.

At least 73 records · Page 4Linked to original sources
PubMed1985

Sympathetic factors in the cardiovascular complications of hypertension: evidence in genetic models for hypertension, stroke and atherosclerosis.

The role of the nervous system in the pathogenesis of cardiovascular complications in hypertension has been clarified to a great extent in genetic rat models for hypertension, stroke and atherosclerosis, especially in the evolution of cardiovascular hypertrophy in hypertension, the most common process related to the pathogenesis and complications of hypertension, in the development of stroke, one of the most common sequelae of hypertension itself and in the pathogenesis of atherosclerotic vascular diseases, the most usual cause of myocardial infarction.

Animals↗
PubMed1984

Simple method for sampling consecutive 24-hour urine for epidemiological and clinical studies.

'Aliquot cups' a newly devised tool for collecting 24-hour urine samples were useful and accurate enough for the estimation of individual 24-hour excretion of sodium and potassium. Data from 24-hour collections for 31 days for 5 healthy volunteers showed relatively large intra- and inter-individual variation. These data suggest that at least 5 consecutive days of urine collection would be needed to make a reasonable estimate of daily intake.

Adult↗
PubMed1984

Dietary prevention of hypertension in animal models and its applicability to human.

Experimental studies in animals and epidemiological studies have suggested that the interaction between genetic and environmental factors is important in hypertension associated with excess salt intake and other dietary factors such as K, protein and fatty acid intake greatly modify the effect of salt on blood pressure in individuals with low or high salt sensitivity. Thus, the detection of salt sensitivity and the modification of salt intake as well as other dietary factors are expected to contribute to the primary prevention of cardiovascular diseases associated with hypertension.

Animals↗
PubMed1984

Common cellular disposition to hypertension and atherosclerosis.

The genetically hypertensive rat models, spontaneously hypertensive rats (SHR) and especially stroke-prone SHR (SHRSP), both develop arterial fat deposits quickly when fed high cholesterol diets. Therefore the morphological and functional characteristics of cultured vascular smooth muscle cells (SMC) from the aorta of SHR, SHRSP and normotensive Wistar-Kyoto (WKY) rats have been compared in order to demonstrate the common cellular mechanisms which induce hypertension and atherosclerosis. Cultured SMC became differentiated after short-term foetal calf serum exclusion from the medium, and despite the general concept of their noncontractility there was opticometric evidence that subcultured SMC contract spontaneously. Smooth muscle cells from SHR, but especially from SHRSP, showed enhanced proliferation which was inhibited by a Ca-antagonist, and accelerated lipid incorporation. It is concluded that these SMC are primarily predisposed to hypertension as well as to atherosclerosis.

Animals↗
PubMedDate not supplied

Vascular, ganglia and cardiac catecholamine disposition in the spontaneously hypertensive rat and in the stroke-prone spontaneously hypertensive rat.

We have examined the disposition of catecholamines in cardiac tissue, mesenteric arteries and ganglia from normotensive Wistar-Kyoto rats (WKY), spontaneously hypertensive rats (SHR) and stroke-prone spontaneously hypertensive rats (SHR-SP). The norepinephrine (NE) contents of mesenteric arteries from all three strains of rats adhered to a pattern which was characterized by the largest concentrations of the catecholamine in arteries from SHR and SHR-SP rats, and the smallest values present in mesenteric arteries from WKY rats. This pattern of NE disposition was not present in either ganglia or cardiac tissue from the three strains of rats. The results highlight two features of the hypernoradrenergic hypothesis in the SHR. Firstly, the enhanced NE contents observed in the blood vessels of the two hypertensive strains are not consistently increased in sympathetic cell bodies or cardiac tissue. Secondly, the significantly enhanced concentrations of NE in the vasculature parallel the elevated direct arterial blood pressure in the two strains of hypertensive rat when compared with the normotensive strain.

Animals↗