PubMed Health⌕ Search

Biomedical subjects

M Manz

Publications and source records attributed to M Manz.

141 records · Page 8Linked to original sources
PubMed1983

[Long-term drug therapy in ventricular cardiac arrhythmias. Is an improvement of the prognosis possible?].

Oral long-term treatment with various antiarrhythmic drugs (aprindine, mexiletine, disopyramide, amiodarone) was assessed in 82 patients with recurrent tachycardias demonstrated in the ECG using programmed ventricular stimulation. It was shown that sudden cardiac death and recurrence of tachycardia were clearly reduced in the group of patients (n = 29) in whom drug treatment prevented ventricular tachycardia following electric stimulation. Amiodarone was demonstrated to be the most effective substance in this respect, notwithstanding some side effects.

Adult↗
PubMed1983

Treatment of recurrent sustained ventricular tachycardia with mexiletine and disopyramide. Control by programmed ventricular stimulation.

Oral antiarrhythmic treatment with mexiletine and disopyramide was evaluated in 34 patients with recurrent sustained ventricular tachycardias by programmed ventricular stimulation, except in a few instances where spontaneous attacks occurred under therapy. Coronary heart disease was present in 17 patients, cardiomyopathy in 11, myocarditis in five, and mitral valve prolapse in one. Complete suppression of ventricular tachycardia was observed in three of 30 patients under mexiletine and in one of 25 patients under disopyramide. Disopyramide slowed the rate of the ventricular tachycardia considerably, while mexiletine had no such influence. For a mean of 24 months, 19 patients were maintained on either substance. Complete suppression of ventricular tachycardia during programmed stimulation predicted freedom from recurrences. Ventricular tachycardias recurred less frequently and at a slower rate in the other patients, but 31% have died. This study shows that complete suppression of ventricular tachycardia by mexiletine or disopyramide can be achieved only in a minority of patients with previously drug-resistant tachycardias.

Adult↗
PubMed1983

[A pulsating tumor in the chest wall].

A pericardial constriction with calcification and a pulsating cyst is an unusual outcome after a pericardial windowing. The application of cardiac computed tomography evaluating the morphological parameters of the heart chambers and the adjacent vessels is an appropriate noninvasive method in the diagnostics of pericardial constriction.

Abscess↗
PubMed1981

[Value and risk of programmed ventricular stimulation in patients with chronic recurrent ventricular tachycardia (author's transl)].

Chronic recurrent ventricular tachycardias represent potentially life-threatening cardiac arrhythmias. We used programmed ventricular stimulation for diagnosis, therapy and control of antiarrhythmic therapy in 17 patients with recurrent ventricular tachycardia. Ventricular tachycardia could be reproducibly induced in 15 patients by programmed stimulation, QRS morphology and rate being comparable to the spontaneously occurring tachycardia. Programmed stimulation was repeated under antiarrhythmic drug therapy. Over a follow-up period of 8 months (3--13 months), the results of the acute electrophysiologic study seem to be predicting oral long-term antiarrhythmic drug therapy. Application of programmed stimulation is associated with potential risks: induction of "non-clinical" more frequent tachycardia: 3/17 pat. = 18%; acceleration of the rate of tachycardia while trying to interrupt it: 5/17 pat. = 30%; necessity of DC-cardioversion: 6/17 pat. = 35%. Despite these risks, programmed ventricular stimulation offers substantial improvement of diagnosis and control of therapy of severely symptomatic patients with suspected or documented ventricular tachycardia and/or fibrillation.

Adult↗
PubMed1980

[Wolff-Parkinson-White syndrome: two accessory pathways concealed conduction accompanied by enhanced AV node conduction (author's transl)].

The case report of a 40 years old female patient with Wolff-Parkinson-White syndrome and concealed conduction of the accessory pathways is presented. Endocardial mapping revealed two re-entry tachycardias with different rates and different sequences of retrograde atrial depolarisation. These accessory bypass tracts were accompanied by enhanced AV node conduction. -- Patients with multiple accessory pathways and enhanced AV node conduction appear to be a special group of WPW-syndrome in respect of life-threatening tachycardias.

Action Potentials↗
PubMedDate not supplied

Multiplane transesophageal echocardiographic evaluation of transvenous defibrillation leads.

Permanent transvenous cardioverter-defibrillator leads were investigated by multiplane transesophageal echocardiography (TEE) (1) to determine whether intracardiac lead segments can be visualized, (2) to verify the position of the coils, and (3) to detect possible thrombus formation. The diagnostic information obtained in 62 patients by TEE was compared to that of transthoracic echocardiography (TTE). Abnormal findings were only visualized by multiplane TEE. However, further controlled studies are needed to determine the clinical relevance of displaced caval (one patient) and ventricular coils (15 patients), ventricular (1 patient) or atrial (6 patients) loops, and of clinically uneventful thrombi (13 patients).

Adult↗
PubMedDate not supplied

Morphology of the mitral valve as displayed by multiplane transesophageal echocardiography.

This study was performed to (1) describe how multiplane transesophageal echocardiography (TEE) facilitates imaging of the entire mitral valve apparatus, and (2) prospectively compare the morphology of the different segments of the mitral apparatus as determined by multiplane TEE and direct surgical inspection. The study consisted of 30 consecutive patients examined by multiplane TEE less than 24 hours before mitral valve surgery. The mitral valve was displayed in transgastric and transesophageal views with the imaging planes specifically aligned to demonstrate continuity between the papillary muscles, chordae tendineae, and leaflet edges. The character and location of morphologic abnormalities identified by findings of preoperative TEE were highly concordant with surgical inspection of the valve (p < 0.0001). Thus multiplane TEE offers the ability to visualize the entire mitral apparatus as a functional unit and to identify morphologic abnormalities of the valve correctly.

Adult↗