Biomedical subjects
Publications and source records attributed to M Manzino.
Cerebrovascular occlusions are rare but well-documented complications of Crohn's disease. We report the case of a young man with regional enteritis and a history of three ischemic strokes, two of them preceded the occurrence of the bowel disease.
Mononeuritis multiplex involving median or common peroneal nerves, presumed to be caused by arteritis of the vasa nervorum, is a relatively rare complication of giant cell arteritis. We present two cases of popliteal neuritis complicating temporal arteritis during corticosteroid treatment.
Changes of simple visual reaction time were analyzed in two groups of unilateral brain damaged patients in order to evaluate to what extent intrahemispheric localization of lesions affects performance. Possible interactions with size were avoided by selecting a localization criterion, i.e. the median section of lesion, uncorrelated with size of damage. By preliminarly establishing that the distribution of lesions in our hemispheric groups did not differ, we were enabled to confirm that intrahemispheric localization of damage has a different bearing on performance depending on side of lesion. In the right hemisphere group slower performances were generally associated with frontal damage whereas in the left hemisphere group localization did not influence the performance. The use of independent indexes for size and locus of lesion proved the existence of an interaction between these parameters in the right hemisphere group.
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Changes of simple visual reaction time were analysed in two groups of unilateral brain-damaged patients in order to evaluate to what extent properties of lesions, clinical parameters and experimental variables might influence speed of motor response. The results confirmed that brain damage, independent of its side, produces a retardation of speed. However, the two hemispheric groups differed in so far as volume of damage had a different bearing depending on side of lesion. In spite of such a difference the presence of a general interaction between size of damage and rate of progression of lesion was noted in both the hemispheres, reminiscent of Jackson's concept of 'lesion momentum'. Aphasia was related to a significant retardation of speed in left-hemisphere-diseased patients, although a specific effect of the disturbance of language could not be demonstrated. Experimental variables such as warned vs unwarned stimulation did not affect significantly the performance of brain-damaged patients.
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We hereby report a case of manic depressive psychosis. The patient had been treated for years with lithium carbonate (600 mg/die, lithium serum concentration equal to 0.7 mEq/l) and came to us under observation for a sensorimotor peripheral neuropathy with mostly axonal degeneration. The central nervous system had not been involved. Excluding any possible causes of peripheral neuropathy and since no precipitating circumstances were ascertained, a clinical improvement was noticed after suspending the therapy.
Groups of left-hemisphere damaged patients, right-hemisphere damaged patients and controls were given the facial recognition test of Benton and Van Allen. Educational level was found to be relevant with regard to the performance of the brain damaged groups, such that a difference between left and right hemisphere-damaged groups became apparent only in patients with higher (greater than 5 years) schooling. The implications of the results are discussed.