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Biomedical subjects

M Marciniak

Publications and source records attributed to M Marciniak.

At least 37 records · Page 2Linked to original sources
PubMed1985

Regeneration of axonal endings of neuromuscular junctions of the soleus muscle in rats under conditions of hypodynamia.

The purpose of the experiments performed was morphometric ultrastructural evaluation of the regeneration of axonal endings after sectioning of nerves in rats kept under conditions of hypodynamia. The investigation indicated a retardation of regeneration of the axonal endings of neuromuscular junctions after denervation of the soleus muscle in rats kept under conditions of hypodynamia as compared with those of the control group. The retarded regeneration of the axonal endings of neuromuscular junctions in experimental animals as compared with that in the control group may be referred to the above mentioned enzymatic and electrolytic disturbances caused by restriction of mobility.

Animals↗
PubMed1985

Does lymphopoiesis regulate tissue mast cells?

An almost twenty-fold increase in mast cell concentration was observed in the spleens of BALB/c mice after sublethal X-irradiation. Repopulation with bone marrow cells abolished this effect.

Animals↗
PubMed1984

Persistence of nerve sprouting with features of synapse remodelling in soleus muscles of adult mice.

An increase in the number of nerve branches of the unmyelinated axon terminals with increasing age was observed in normal adult mouse motor endplates. In addition, ultrastructural investigation revealed signs of nerve retraction. A combined light and electron microscopic investigation was performed on zinc-iodine-osmium stained endplates in soleus muscles. The number of branch points in a synapse, endplate length and muscle fiber diameter were evaluated in "young adult" (3 months) and adult (6 and 11 months) mice. For all 3 parameters, 3-month-old animals had the lowest values. Eleven-month-old animals had more branch points and larger endplate lengths than 6-month-old animals while there was no significant difference in fiber diameters. Branch point numbers and endplate length were correlated in each muscle while fiber diameters did not correlate with any of the other parameters. The ultrastructure of 15 thin nerve branches--likely candidates for new branches--was investigated in serial section and in 14 of them synaptic contacts were found. Near such contacts, empty gutters, possibly abandoned former synaptic sites, were present in several cases. It is concluded that there is continual nerve sprouting in synapses of adult mice and that sprouts form synaptic contacts. The possible signs of nerve retraction observed indicate that, as in the frog, synaptic contacts in mouse muscles undergo some continual remodeling.

Aging↗
PubMed1983

Influence of physical exercise after long-lasting hypodynamia on the morphological parameters of muscle fibers.

The purpose of this research was morphometric ultrastructure evaluation of the fibers in muscles taking part in the flight of pigeons forced to exercise after a long period of hypodynamia. It was found that following physical exercise, after 12 and 18 months of mobility limitation, there appeared marked qualitative and quantitative changes: a diminution of the volume fraction and number of mitochondria, increase of smooth sarcoplasmic reticulum and sarcoplasm, and a significant decrease of the number of glycogen granules as compared with those after 18 months hypodynamia. The above described changes were more pronounced in the supracoracoideus than in the pectoralis muscle.

Animals↗
PubMed1983

Morphometric ultrastructural study of the regeneration of soleus muscle in hypokinesia.

The aim of the present study was a morphometric ultrastructural evaluation of regenerating soleus muscle fibers after denervation under conditions of hypokinesia. It was found that in rats kept under conditions of hypokinesia degenerative changes in the soleus muscle after denervation are more pronounced than in the control. On the 36th day after denervation of muscle, symptoms of regeneration of muscle fibers were observed. It was more pronounced in the control than in the experimental groups. Denervation and immobilization applied simultaneously causes more severe degeneration and atrophy of muscle fibers than does the action of only one of these factors.

Animals↗
PubMed1983

Morphometric ultrastructural evaluation of the axonal endings in the neuromuscular junctions of pigeons after long lasting limitation of movement.

Ultrastructural quantitative and qualitative evaluations of axonal endings in the neuromuscular junctions of latissimus dorsi posterior muscle in the birds kept under limited mobility are performed. The investigation showed that as the time of hypodynamia is prolonged the degenerative changes appear in most of the axonal endings. In the earlier period of limited mobility the number and volume of internal structures of the axonal endings (mitochondria and synaptic vesicles) decreased. In the longer period of hypodynamia fragmentation of axonal endings and their resorption by the Schwann cell were observed. These changes are considered as the third, final period of degeneration of the investigated structures.

Animals↗
PubMed1979

Stereological ultrastructural analysis of the axonal endings in the neuromuscular junction of rats after a flight on Biosputnik 782.

The study was aimed at quantitative and qualitative evaluation of the axonal endings of the neuromuscular junction in the quadriceps femoris muscle and the diaphragma in animals after a space flight. Quantitative morphometric studies at the ultrastructural level demonstrated a statistically significant diminution of the mean number of mitochondria and synaptic vesicles on the cross section of the axonal endings. Qualitative analysis of electronogrames revealed morphological changes indicating degeneration and various degrees of injury in some of the axonal endings of the neuromuscular junction.

Animals↗
PubMed1979

Ultrasonic investigations of the soleus muscle after space flight on the Biosputnik 936.

The study was aimed at quantitative and qualitative evaluation of the muscle fibres and the axonal endings of the neuromuscular junctions in the soleus muscle of animals after a space flight on Biosputnik 936. Ultrastructural morphometric studies of the muscle fibres demonstrated diminished volume of sarcomer and accumulation of glycogen granules. The mean number of mitochondrial profiles decreased. The investigations of the axonal endings of the neuromuscular junctions in the soleus muscle showed diminution of the mean number of synaptic vesicles and swelling of the mitochondria. This changing in the fibres and axonal endings we can interpret as the first step of degeneration.

Animals↗