[Efficacy of Mezlocillin in open-heart surgery].
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Biomedical subjects
Publications and source records attributed to M Maruko.
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Aneurysmectomy is generally the first choice as treatment in most patients with abdominal aortic aneurysm. However, justification of surgical procedures in the aged has been questioned, because of the risk which increases with chronologic age. In the present study, our experience with patients over 70 who underwent abdominal aortic aneurysmectomy is discussed. Forty patients with abdominal aortic aneurysm underwent surgery in our institution up to January, 1983. Ten of these patients were 70 years or older. Operation was performed electively in 6 and as an emergency in 4. The one operative death (10 per cent) was the case of a 74-year old woman with a ruptured aneurysm. The operative mortality was 17.5 per cent in patients under 70 years of age. It would appear that advanced age, per se, is not a contraindication for abdominal aneurysmectomy.
One hundred and eighty-one patients (101 men and 80 women) underwent 61 congenital and 120 acquired heart operations using cold blood potassium cardioplegia as the method of myocardial protection at Kagoshima University from August, 1978 to August, 1981. Hospital deaths occurred in 18 patients (9.8%), and 4 cases were late death (2.2%). Multivariate analysis revealed no significant relationship between type of heart disease and operative mortality or the occurrence of post-operative low output syndrome. To evaluate the superiority of cold blood cardioplegia for myocardial protection, we carried out 20 orthotopic heart transplants in dog; 16 transplanted grafts could maintain the circulation of recipient without cardiopulmonary bypass. Cardiac contractility following 90-minute ischemic time showed 97 to 100% of the control values without any inotropic drugs. These clinical and experimental findings suggest that cold blood potassium cardioplegia provides excellent myocardial protection during the ischemia of the heart.
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In the majority of cases, total anomalous pulmonary venous drainage (TAPVD) results in death in infancy or early childhood, with very few cases surviving until adulthood. We report here the surgical correction of TAPVD in two adult patients, a 43-year-old male and 51-year-old female. The postoperative course was uneventful in the two patients, both of whom showed marked improvement of clinical features. The six other surgical corrections of TAPVD in patients over 40 years of age that have been reported in Japan are also reviewed. The favorable results in these cases were associated with the following common factors: 1) unobstructed forms with large drainage veins, 2) large interatrial communication, 3) normal pulmonary vascular resistance with normal or slightly elevated pulmonary artery pressure, 4) low grade, delayed cyanosis, and 5) the supracardiac type of TAPVD.